Cited by Biomaterials Enhancing Localized Cancer Therapy Activated Anti-Tumor Immunity: A Review

Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma DOI

Jiamin Ye,

Yueyue Fan,

Yong Kang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Language: Английский

Citations

DNA‐Capturing Manganese‐Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS‐STING Pathway and Maintaining Tumor‐Infiltrating CD8⁺ T‐Cell Stemness DOI

Shuai Zhang,

Chunjie Wang, Yujie Zhu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

The radiotherapy-induced release of DNA fragments can stimulate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator interferon genes (cGAS-STING) pathway to prime antitumor immunity, but this is expected be less potent because inefficient cytosolic delivery negatively charged fragments. In study, manganese-coordinated chitosan (CS-Mn) microparticles with selective DNA-capturing capacity are concisely prepared via a coordination-directed one-pot synthesis process potentiate immunogenicity radiotherapy. obtained CS-Mn that undergo rapid disassembly under physiological conditions selectively bind form positively DNA-CS assemblies strong electrostatic interaction between linear and molecules. They thus enable efficient in presence serum cooperate Mn2+ activate cGAS-STING dendritic cells. Upon intratumoral injection, markedly enhance efficacy radiotherapy against both irradiated distal tumors different tumor models collectively promoting tumor-infiltrating CD8+ T-cell stemness activation innate immunity. radiosensitization effect further augmented by concurrently applying anti-programmed cell death protein 1 (anti-PD-1) immunotherapy. This work highlights an ingenious strategy prepare Trojan horse-like as cGAS-STING-activating radiosensitizers for effective radioimmunotherapy.

Language: Английский

Citations

Manganese-coordinated nanoparticles loaded with CHK1 inhibitor dually activate cGAS-STING pathway and enhance efficacy of immune checkpoint therapy DOI

Rui Huang, Yijia Wu, Feiyang Shen

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123199 - 123199

Published: Feb. 20, 2025

Language: Английский

Citations

Injectable 2D‐MoS₂‐integrated Bioadhesive Hydrogel as Photothermal‐Derived and Drug‐Delivery Implant for Colorectal Cancer Therapy DOI

Xiaojun Long,

Jiawei Wang,

Huijuan Wang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract Photothermal therapy (PTT) combined with chemotherapy using hydrogel as a delivery platform is considered promising strategy for the treatment of advanced colorectal cancer (CRC). However, maintaining stability photo‐absorbing agents (PTA) in and ensuring that remains anchored to tumor tissue presents significant challenges. Herein, this work introduces an injectable 2D molybdenum disulfide (2D‐MoS 2 )‐integrated adhesive hydrogel, specifically N‐(2‐aminoethyl)‐4‐(4‐(hydroxymethyl)‐2‐methoxy‐5‐nitro‐sophenoxy) butanamide‐linked sodium alginate‐MoS ‐5‐fluorouracil (AlgNB/MoS /5‐FU). This functions near‐infrared light (NIR)‐triggered photothermal drug‐delivery implant CRC treatment. The MoS nanosheets maintain superior dispersibility exhibit highly efficient NIR‐triggered effect. Importantly, aldehyde group AlgNB also imparted adhesion used infiltrate anchor within tissue. AlgNB/MoS /5‐FU shows remarkable efficacy inhibiting SW480 cells proliferation promoting regression by triggering PTT delivering 5‐FU drug both vitro vivo studies. potential synergistic mechanism may contribute DNA repair enhancing robust immune response. Therefore, research provides valuable strategic insights localized CRC.

Language: Английский

Citations

Recent advances in nanomaterials for integrated phototherapy and immunotherapy DOI

Zhuqing Sun, Nannan Wang, Yelin Wu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608

Published: March 27, 2025

Language: Английский

Citations

Modular Engineering of Enzyme‐Activatable DNA Nanodevices for Endoplasmic Reticulum‐Targeted Photodynamic Antitumor Therapy DOI

Dejie Lu,

Yanfei Jia, Yaoxuan Chen

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract Endoplasmic reticulum (ER)‐targeted photodynamic therapy (PDT) has garnered wide attention for its potential to improve tumor treatment outcomes. However, achieving spatially selective control over the activation of photosensitizers (PSs) within ER remains a major challenge. In this study, programmable DNA nanodevice, termed EDEP, designed targeted delivery and localized PSs, thereby ER‐specific activatable therapy, is presented. This modular engineered nanodevice comprises an enzyme‐activatable, DNA‐based PS (ED), nanocarrier ER‐targeting ligand, allowing it accumulate specifically lumen. The ED features unique enzyme‐responsive turn‐on mechanism that selectively activates upon interaction with enzyme, facilitating controlled reactive oxygen species (ROS) generation at subcellular site. It demonstrated EDEP enables ROS production in ER, leading significant cytotoxicity cells. Furthermore, induces mitochondrial permeability transition pore opening, resulting dysfunction amplified cell death. work presents enzyme‐controlled, ER‐targeted PDT strategy holds promise precise cancer therapy.

Language: Английский

Citations

Mutual boost between free radicals and photothermal effect for synergistic photothermal/thermodynamic antibacterial therapy DOI

Haimeng Liu,

Chengyang Ban,

Chen Fang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114742 - 114742

Published: April 28, 2025

Language: Английский

Citations

Injectable 2D-MoS 2 -integrated bioadhesive hydrogel as photothermal-derived and drug-delivery implant for colorectal cancer therapy DOI

Xiaojun Long,

Jiawei Wang,

Huijuan Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Patients with advanced colorectal cancer (CRC) and diffuse peritoneal metastasis are not eligible for surgical intervention, calling more efficient precise treatment strategies to complement the traditional systemic chemotherapy intraperitoneal chemotherapy. Herein, an injectable two-dimensional molybdenum disulfide (2D-MoS₂)-integrated adhesive N-(2-aminoethyl)-4-(4-(hydroxymethyl)-2-methoxy-5-nitro-sophenoxy) butanamide-linked sodium alginate-MoS₂-5-fluorouracil (AlgNB/MoS₂/5-FU) hydrogel, which can function as near-infrared light (NIR)-triggered photothermal drug-delivery implant CRC is introduced. Ultraviolet (UV) light-activated aldehyde groups in AlgNB bound surface-modified MoS₂ nanosheets via a Schiff base reaction. The maintained superior dispersibility hydrogel exhibited highly NIR-triggered effect. More importantly, group also imparted tissue adhesion was used infiltrate fix tumor tissue. Combining applications 5-FU drug delivering implant, AlgNB/MoS₂/5-FU shows remarkable capability inhibition of SW480 cells tumour regression by triggering therapy (PTT) both in vitro vivo studies. possible synergistic mechanism PTT could contributed inhibit DNA repair boost robust immune response. Therefore, this research provides distinct guidance localized enormous potential clinical setting.

Language: Английский

Citations

Biomaterials Enhancing Localized Cancer Therapy Activated Anti-Tumor Immunity: A Review DOI

J. Yao,

Zhencun Cui,

Feifei Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 13(1), P. 117 - 136

Published: Nov. 6, 2024

This article reviews the application of biomaterials in combination with immunotherapy to enhance localized treatment tumors, along current challenges and future development directions this field.

Language: Английский

Citations