Lipid nanoparticles in antiretroviral therapy: A nanotechnology breakthrough for HIV/AIDS treatment

HIV Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Background The development of an effective drug delivery system for the treatment HIV/AIDS is a global challenge. conventional approach, namely highly active antiretroviral therapy (HAART), has increased lifespan patients. While drugs are critical managing HIV/AIDS, they not considered curative treatments and require additional supportive depending on clinical condition. Theoretically, all steps in life cycle HIV potential targets therapy. However, eradication still possible with these approaches account some limitations. Lipid nanoparticles antiretrovirals (ARVs) as primarily lower toxicity ARVs ease scaling up manufacturing, also offer functionalization capabilities, targeted delivery, controlled release profiles load capacity. Methods Data were retrieved from various online electronic resources, including PubMed, Google Scholar Scopus among others. Keywords such ‘lipid nanoparticles’, ‘antiretroviral therapy’, ‘HIV/AIDS’ ‘nanomedicine’ used to formulate search strategies across approximately 106 research review articles. Results Lipid‐based nanoparticles, liposomes, solid lipid nanostructured carriers hybrid have been reported being strategy anti‐HIV drugs. Conclusions This discusses how lipidic can be deliver their target sites manner considers fate within animal body.

Language: Английский

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Development of a Poly(cation‐π) Antibacterial Agent for Thermal and Moisture Managing in PET Fabrics

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Functional textiles that inhibit bacterial proliferation while providing advanced moisture and thermal management are increasingly in demand for regulating personal microclimates enhancing thermal‐wet comfort. However, traditional wet‐processing technologies face challenges terms of specific functionalities limited wash durability, accompanied by severe water waste pollution. In this study, a scalable Janus polyethylene terephthalate (PET) fabric comprising molecular engineering poly(cation‐π)‐based macromolecule (PXDAG) is developed through an ultrasonic‐assisted spray approach. Density functional theory (DFT) calculations reveals the formation cation‐π hydrogen interactions between PXDAG with cationic nitrogen aromatic PET, synergistically boosting antibacterial persistence. The obtained exhibits efficient sustained activity against E. coli S. aureus (>99.99%), even after 30 cycles. Furthermore, fabrics anchored on one side demonstrates capacity directional sweat transport, maintaining skin temperature 6.0 °C lower than surrounding environment. Further NMR analysis indicates intermolecular contributed to robust non‐covalent cohesion effectively dissipated fracture energy improve interfacial threshold. Combined advantages low cost, eco‐friendliness, safe operation, design offers promising solutions applications comfortable sportswear, health textiles, wet

Language: Английский

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Antiviral Surface Coatings: From Pandemic Lessons to Visible-Light-Activated Films

Materials, Journal Year: 2025, Volume and Issue: 18(4), P. 906 - 906

Published: Feb. 19, 2025

The increasing need for effective antiviral strategies has led to the development of innovative surface coatings combat transmission viruses via fomites. aim this review is critically assess efficacy in mitigating virus transmission, particularly those activated by visible light. alarm created COVID-19 pandemic, including initial uncertainty about mechanisms its spread, attracted attention fomites as a possible source transmission. However, later research shown that surface-dependent infection be carefully evaluated experimentally. By briefly analyzing virus-surface interactions and their implications, highlights importance shifting solutions. In particular, visible-light-activated use reactive oxygen species such singlet disrupt viral components have emerged promising options. These can allow obtaining safe, continuous, long-term active biocidal surfaces suitable various applications, healthcare environments public spaces. This indicates while significance fomite context-dependent, advances material science provide actionable pathways designing multifunctional, coatings. innovations align with lessons learned from pandemic pave way sustainable, broad-spectrum solutions capable addressing future health challenges.

Language: Английский

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The conversion of tannic acid into carbon dots enhances its antiviral activities

Carbon letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

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Recent Advances in Carbon Dots: Applications in Oral Diseases

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Over the years, oral and maxillofacial injuries, mainly caries, pulpitis, bone defects, cancer, often involve a variety of organs tissues, resulting in structural dysfunction, adverse effects on facial appearance, not only affecting people's chewing, swallowing other physiological functions, but also to physical mental health burden. As type carbon-based nanomaterial, carbon dots (CDs) have been widely used diagnosis treatment diseases due its excellent optical properties, good biocompatibility low toxicity. In addition, surface functionalization or passivation CDs can change properties CDs, such as water solubility chemiluminescence, broaden biomedical potential CDs. this review, latest research progress modified hard tissue regeneration, tumor treatment, antibacterial activity, dentin pulp complex teeth whitening, wound healing, drug release, fluorescence tracer bioimaging were reviewed. we discussed problems future direction development.

Language: Английский

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