Reactive Oxygen and Nitrogen Species – “Nanosweeper” for Rheumatoid Arthritis Theranostics by Macrophage Reprogramming DOI

Pingli Dong,

Haoyu Qiu, Rui Wu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(51), P. 70322 - 70338

Published: Dec. 12, 2024

Excessive reactive oxygen and nitrogen species (RONS) accumulation in joints are significant variables that affect the course of rheumatoid arthritis (RA). Scavenging RONS to remodel macrophage homeostasis is a potentially powerful treatment for RA. Here, visualized "nanosweeper" by functionalizing ultrasmall Gd/Fe3O4 nanoparticles with thiol-polyethylene glycol-phosphoric acid 2-(3-(2-aminophenyl)ureido) ethyl methacrylate hydrochloride (APUEMA), namely GIA NPs, can simultaneously scavenge both nitric oxide (NO) (ROS), as well enhance magnetic resonance imaging (MRI) diagnosis therapy NPs could not only eliminate NO reactions between o-phenylenediamine moieties APUEMA molecules but also remove ROS superoxide peroxidase activities Fe3O4 thiol. In vitro vivo experiments revealed simultaneous scavenging strategy inhibited overactivation cyclic guanosine monophosphate/protein kinase G (cGMP/PKG) signaling pathway reprogram polarization states macrophages interfered metabolism alleviate addition, dual-modal nanoprobes MRI, exhibited capacity early RA lesions monitoring during process. The provides promising integrated platform

Language: Английский

Antimicrobial Phenolic Materials: From Assembly to Function DOI Creative Commons
Wanjun Xu, Zhixing Lin, Christina Cortez‐Jugo

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

Citations

3
pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation DOI
Xi Zhang,

Yongzhe Liu,

Ziwei Wang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123322 - 123322

Published: Jan. 1, 2025

Language: Английский

Citations

1
Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production DOI Creative Commons
Fei Yu, Xing Zhao, Ting Jiang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Bio-inspired coral-derived scaffolds have been adopted for bone regeneration. However, these confront challenges such as the limited osteoinductive properties, environmental concerns, and ambiguous calcification mechanisms in coral proteins. In this study, role of recombinant protein galaxin promoting osteogenesis is investigated. The observations reveal that regulates mitochondrial metabolism mouse pre-osteoblasts by interacting with β subunit ATP synthase. This ultimately promotes pre-osteoblasts. Furthermore, integrated gelatin methacryloyl (GelMA) assess osteogenic potential resulting galaxin-GelMA composites mandibular defects. emphasize distinctive regulating functionality osteogenesis. Additionally, provide prospective insights further applications bio-inspired proteins regenerative medicine.

Language: Английский

Citations

1
A Coordinated Cascade Therapy‐Based Janus Fibrous Membrane Drives Bone Regeneration through Mediating the Transformation of Energy Metabolism Pathway DOI Open Access

X. Cheng,

Na Xu,

Hao Wu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Bone regeneration is synergistically regulated by growth factors, which are expressed in a coordinated cascade of events. An ideal guided bone membrane (GBRM) shall present barrier and antibacterial functions, promote osteogenesis through time‐controlled release factors. In this study, therapy‐based Janus fibrous fabricated coaxial electrospinning layer‐by‐layer self‐assembly technology (LBL). Specifically, the oriented PCL/PLGA fibers loaded with zinc oxide nanoparticles (ZnO NPs) designed as outer layer, randomly arranged core‐shell Gelatin/PLLA nanofibers employed inner layer to rapidly aFGF sustainedly BMP‐2. Results demonstrated that achieved multiple functions satisfy essential requirement regeneration, exhibited remarkable ability, function, osteoinductive ability. Interestingly, significant enhancement oxidative phosphorylation (OXPHOS) major energy supply pathway decisive factor drive osteogenic differentiation BMSCs induced membranes. This study provides novel strategy fabricate multifunctional membranes/scaffolds, displaying great potential applications tissue engineering. Besides, understanding synergistic mechanism factors on cellular metabolism process can provide deeper insights into factors‐mediated optimizing healing outcomes.

Language: Английский

Citations

0
Antimicrobial Phenolic Materials: From Assembly to Function DOI Creative Commons
Wanjun Xu, Zhixing Lin, Christina Cortez‐Jugo

et al.

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

Citations

0
A multiple-crosslinked injectable hydrogel for modulating tissue microenvironment and accelerating infected diabetic wound repair DOI Creative Commons
Zhengduo Zhang,

Yuanyuan Ding,

Huipu Yuan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 18, 2025

Language: Английский

Citations

0
A Protective Growth Factor Delivery Strategy Based on Polyphenol-Protein Self-Assembly to Promote Inflammatory Bone Regeneration DOI
Ling Li, Fei Gao, Huanrong Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123272 - 123272

Published: March 1, 2025

Language: Английский

Citations

0
Cascade reaction hydrogel with enzyme-catalyzed endogenous glucose for diabetic wound healing DOI

Ning Wei,

Liangyu Wang, Haibo Wang

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137616 - 137616

Published: April 16, 2025

Language: Английский

Citations

0
Dual-Stabilized Selenium Nanoparticles with Chitosan and SS31 Peptide: Resolving instability for enhancing ROS elimination, suppressing inflammation, and combating bacterial infections DOI

Panpan Ming,

Yuwen Wei,

Yawen Zhu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114749 - 114749

Published: May 1, 2025

Language: Английский

Citations

0
Ultrasound‐Driven Piezoelectric Strategy and Performance: Polyurethane‐Based Functioning Networks in Actuating Bone Repair DOI
Xiaoyu Lei,

Yangxue Yao,

Fu‐Hua Sun

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract When severe defects bone occur, limited mobility in patients is accompanied by delayed signal transmission and osteogenesis. A sonodynamic therapy based on ultrasound‐driven piezoelectric scaffolds designed to restore cellular connections for regeneration. series of 3D‐printed are fabricated using different polyurethane‐based composites (hydroxyapatite/BaTiO 3 ) further polarized achieve a high constant. Driven low‐intensity pulsed ultrasound (LIPUS), the electrical signals from optimized, achieving an increased open‐circuit voltage (197 mV) due interconnected phase. The cues elevated cytosolic mitochondrial calcium levels marrow mesenchymal stem cells (BMSCs), where ions acted as key second messenger, fortifying energy metabolism exciting activity. After applying rat skull defects, signaling pathway, oxidative phosphorylation, citrate cycle actuated through functioning networks, while HIF‐1 pathway angiogenesis, AMPK MAPK pathways osteogenesis collectively improved. optimized facilitated ≈27.85% (8 W) with early neovascularization (4 defects. Given efficiency piezoelectric‐transducing network, offers sustained mitochondria‐excited treatment maintain viability.

Language: Английский

Citations

0