Biomass Conversion and Biorefinery, Journal Year: 2024, Volume and Issue: unknown
Published: July 25, 2024
Language: Английский
Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Electrospinning offers a versatile platform for developing nanofibrous scaffolds capable of enhancing the therapeutic potential photodynamic therapy (PDT). Photosensitizer (PS) loaded fibers exhibit high surface area‐to‐volume ratio, promoting efficient drug delivery, prolonged retention at target site, and controlled release profiles. Inducing reactive oxygen species (ROS) generation through light activation targeted approach, selectively generating cytotoxic effects in cancerous or pathogenic cells while minimizing damage to healthy tissue. This selective cytotoxicity arises because ROS are produced only illuminated areas where PS releases accumulates, limiting their harmful desired regions. Additionally, PS‐loaded highly effective wound healing applications, cell proliferation tissue regeneration providing barrier against microbial infections. review highlights recent advances design biomedical application nanofibers, emphasizing influence on viability effectiveness inhibition, thereby setting stage future innovations cancer therapy, healing, infection control.
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers promising alternative by reducing the bacterial adaptability antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due hydrophilicity photosensitizers, short lifespan, narrow diffusion radius reactive oxygen species (ROS), risk exacerbating inflammation. this study, we report bacterial-targeting supramolecular nanophotosensitizer for combating multidrug resistant bacteria. nanophotosensitizer, formed through host–guest interactions self-assembly tetra-cyclodextrin-modified silver porphyrin (AgTPP-CD4), adamantyl-modified phenylboronic acid (Ad-PBA), curcumin (Cur), can effectively target kill methicillin-resistant Staphylococcus aureus (MRSA). Moreover, it reduces inflammation promotes wound healing in MRSA-infected wounds without inducing drug resistance. combination chemistry targeted PDT strategy infections.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 509, P. 160975 - 160975
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Alloys and Compounds, Journal Year: 2025, Volume and Issue: unknown, P. 179620 - 179620
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137292 - 137292
Published: March 10, 2025
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(6), P. 770 - 770
Published: March 14, 2025
Wound infections pose a significant challenge in healthcare settings due to prolonged healing times and the emergence of antibiotic-resistant bacteria. Traditional wound dressings often fail provide sustained drug release, optimal moisture retention, effective antibacterial protection, leading suboptimal therapeutic outcomes. This study aimed optimize develop neomycin-integrated hydrogels crosslinked via tannic acid (TA) for treatment infectious wounds. The were optimized using central composite experimental design. amounts polyvinyl alcohol (PVA, 10–20% w/w) polyvinylpyrrolidone (PVP, 5–20% varied mixed with fixed concentration TA (1% as crosslinker. water content (%), absorption erosion vapor transmission rate (WVTR), mechanical properties evaluated. Neomycin was integrated hydrogel, activity against Staphylococcus aureus studied time-kill analysis method. hydrogel formula contained PVA PVP at ratio 20:19.89 by weight. resulting possessed good physical had 71.86%, 124.96%, minimal 33.08%, WVTR 5567 g/m2/24 h. Furthermore, showed desirable elasticity, Young’s modulus 474.81 Pa tensile strength that could resist breakage upon application. inhibited bacterial growth comparably neomycin solution (0.5% w/v). Therefore, proven be promising natural crosslinker demonstrated propitious platform cutaneous application, which used treat infected wounds future.
Language: Английский
Citations
0
Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102697 - 102697
Published: March 30, 2025
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Abstract In the treatment of infectious keratitis, therapeutic strategies often prioritize enhancing bactericidal efficacy. However, endotoxins released from Gram‐negative bacteria cause inflammatory reaction, leading to corneal structural damage and scar formation. Given that polymyxin B (PMB) can bind neutralize lipopolysaccharide (LPS), this study employs large‐pore mesoporous silica nanoparticles (lMSNs) grafted with PMB as carriers for cationic antibacterial carbon quantum dots (CQDs) prepare CQD@lMSN‐PMB, which enables synchronous sterilization endotoxin neutralization. acidic microenvironment, accelerated release CQDs eliminates 99.88% within 2 h, effectively substituting immune mediated sterilization. Notably, CQD@lMSN‐PMB exhibits exceptional LPS neutralization performance (2.22 µg LPS/mg CQD@lMSN‐PMB) due its high specific surface area. an keratitis model, inflammation subsides significantly first day intervention is completely resolved by 3. By 2, interleukin‐1β, interleukin‐6 tumor necrosis factor‐α in group decrease 86.99%, 91.15%, 77.56%, respectively, compared CQDs‐only group. Ultimately, integrity transparency are preserved, suppressed expressions fibrosis‐related factors including matrix metalloproteinase 9, transforming growth factor‐β α‐smooth muscle actin. Therefore, strategy outperforms monotherapy focused solely on or
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 18, 2025
Abstract Epoxy‐type afterglow luminescence is a cascade reaction of photochemical defects caused as result the formation and release epoxy intermediates, exhibiting continuous phenomenon that remains intrinsic after excitation, with extremely impressive signal‐to‐background ratio (SBR) level in vivo. Afterglow based on this epoxy‐type mechanism ideally suited for applications developments diagnosis treatment biological diseases. In tutorial review, work aims to deeply elaborate mechanisms materials present application imaging Lastly, future perspectives potential challenges technology preclinical diagnostic, therapeutic, predictive analyses, well clinical translations are discussed.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143331 - 143331
Published: April 1, 2025
Language: Английский
Citations
0