Ultrasound‐Activated Selenium Nanocarrier: Bactericidal Enhancement and Osseointegration Promotion for Implant‐Associated Infections DOI

Zhiying Cao,

Renhao Xu,

Wenyi Zheng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Implant‐associated infections (IAIs) are common and challenging complications of orthopedic surgery. The physical barrier formed by biofilms the antioxidant defense system bacteria shield them from attack antimicrobial agents immune cells, leading to irreversible bone loss failure osseointegration. To address these challenges enhance osseointegration in presence biofilm infections, a sequential therapy strategy is proposed using an ultrasound‐activated nanocarrier, PLGA@H/Se, designed disrupt bacterial defenses subsequently enhancing osteogenic differentiation. As expected, when activated ultrasound, induces cavitation effect that disrupts outer biofilm, while promoting deep delivery encapsulated SeNPs peptide HHC‐36. target internal H₂S‐based bacteria, thereby synergistically bactericidal Furthermore, sustained release regulates selenoprotein expression, boosts stress responses, activates Wnt/β‐catenin pathway, which helps restore differentiation potential BMSCs impaired oxidative damage, both vitro vivo. Collectively, this ultrasound‐based facilitates functional under pathological conditions, offering practical comprehensive for treating IAIs.

Language: Английский

Multifunctional integrated polyphenol-copper nanozymes for sepsis-induced acute liver injury via ameliorating endoplasmic reticulum stress and reprogramming inflammatory microenvironment DOI

D. Che,

Yao Xiao, Xiaoyong Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160293 - 160293

Published: Feb. 1, 2025

Language: Английский

Citations

1
Cell-free DNA-scavenging nano/microsystems for immunotherapy DOI
Wenhan Zhao, Yang Zhou, Lichen Yin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113609 - 113609

Published: March 1, 2025

Language: Английский

Citations

0
Therapeutic potential of naturally derived carbon dots in sepsis-associated acute kidney injury DOI Creative Commons
Lei Wang,

Zhong-Yao Li,

Chong-Lei Zhong

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 11, 2025

Abstract Background Sepsis is a life-threatening infectious disease characterized by an uncontrolled inflammatory response and consequent multi-organ dysfunction. The kidneys, as primary excretory organs with high blood flow, are particularly susceptible to damage during sepsis. Nonetheless, the existing treatment options for sepsis-associated acute kidney injury (SA-AKI) still restricted. Nanomedicine, especially carbon dots (CDs), has attracted considerable interest lately outstanding biomedical characteristics. Methods To avoid generation of toxic effects, natural CDs derived from Ziziphi Spinosae Semen (Z-CDs) were synthesized employing hydrothermal method. free radical scavenging capabilities Z-CDs evaluated utilizing ABTS assay, NBT method, Fenton reaction. A lipopolysaccharide (LPS)-stimulated RAW 264.7 cell model was used explore therapeutic potential on cellular oxidative stress inflammation. CuSO 4 -induced zebrafish inflammation LPS-exposed SA-AKI mouse employed assess efficacy in vivo. Results exhibited distinctive unsaturated surface functional groups, which confer exceptional biocompatibility ability scavenge radicals. Moreover, effective eliminating excess reactive oxygen species (ROS) cells, thus protecting mitochondrial function damage. Notably, have demonstrated significant benefits tissue minimizing side effects. In mechanism, effectively reduced ROS production, thereby alleviating responses macrophages through suppression NF-κB pathway. Conclusions This study developed multifunctional nanomedicine traditional medicinal herb, providing promising pathway advancement innovative drug therapies treat SA-AKI.

Language: Английский

Citations

0
Bacterial Specific Recognition of Sulfonium Poly(Amino Acid) Adsorbents for Ultrafast MRSA Capture Against Bloodstream Infection DOI
Zhenyan Zhang, Lei Wang, Qing Yu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) bloodstream infections pose significant health risks, potentially leading to severe conditions such as bacteremia. Developing effective treatments eliminate resistant bacteria from the bloodstream, simultaneously mitigate infection‐related complications, and reduce mortality remains challenging. Herein, microspheres are synthesized with bacterial elimination inflammation prevention by crosslinked sulfonium poly(amino acids). As‐synthesized microsphere, PM 1 0.6B MS, exhibits an ultrafast adsorption efficiency of 0.41 × 10 8 CFU mg −1 min for MRSA, which positions highest index among reported resin inorganic adsorptions. This bacterial‐specific efficient capture MS is attributed its strong interactions teichoic acids in MRSA (Ka: 1.8 5 M ) rather than acting phospholipids mammalian cells. Unlike present resin‐based adsorbent, example, heparin‐modified polyethylene only commercial Seraph ® 100, kills adsorbed within h can be reused simple treatment. Meanwhile, also shows good hemocompatibility longer thrombin activation time risk thrombosis hemolysis. In vivo experiments further confirm abilities prevent removing bacteria. adsorbent a promising candidate early treating life‐threatening infections, preventing bacteremia subsequent organ damage.

Language: Английский

Citations

0
Ultrasound‐Activated Selenium Nanocarrier: Bactericidal Enhancement and Osseointegration Promotion for Implant‐Associated Infections DOI

Zhiying Cao,

Renhao Xu,

Wenyi Zheng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Implant‐associated infections (IAIs) are common and challenging complications of orthopedic surgery. The physical barrier formed by biofilms the antioxidant defense system bacteria shield them from attack antimicrobial agents immune cells, leading to irreversible bone loss failure osseointegration. To address these challenges enhance osseointegration in presence biofilm infections, a sequential therapy strategy is proposed using an ultrasound‐activated nanocarrier, PLGA@H/Se, designed disrupt bacterial defenses subsequently enhancing osteogenic differentiation. As expected, when activated ultrasound, induces cavitation effect that disrupts outer biofilm, while promoting deep delivery encapsulated SeNPs peptide HHC‐36. target internal H₂S‐based bacteria, thereby synergistically bactericidal Furthermore, sustained release regulates selenoprotein expression, boosts stress responses, activates Wnt/β‐catenin pathway, which helps restore differentiation potential BMSCs impaired oxidative damage, both vitro vivo. Collectively, this ultrasound‐based facilitates functional under pathological conditions, offering practical comprehensive for treating IAIs.

Language: Английский

Citations

0