Additive manufacturing, Journal Year: 2024, Volume and Issue: unknown, P. 104449 - 104449
Published: Sept. 1, 2024
Language: Английский
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 257 - 273
Published: Jan. 1, 2025
Language: Английский
Citations
2
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Abstract 3D printing has greatly improved the precision of cell and biomaterial placement, enabling accurate reproduction tissue models with sustainable potential. Various techniques, including inkjet printing, extrusion‐based vat photopolymerization, offer unique advantages but often fail to replicate full complexity native tissues because material scalability limitations. Hybrid bioprinting, combining multiple techniques in a single process, shown great potential creating complex multifunctional capabilities, ranging from patient‐specific implant fabrication full‐scale organ development. It capitalizes on strengths integration sustainable, renewable biomaterials at varying resolutions, nano microscale. This approach addresses both biological environmental responsibility by minimizing waste enhancing sustainability engineering processes. Despite progress, substantial gap remains between current technologies bioengineering requirements. A deep understanding hybrid its underlying mechanisms is crucial. Herein, this review summarizes discusses recent advancements systems for fabricating multiscale hierarchical models, focusing challenges field. aims insights identify key requirements advancing technology toward developing functional, biomimetic constructs.
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 12, 2025
Polypeptides are highly valued in biomedical science for their biocompatibility and biodegradability, making them valuable drug delivery, tissue engineering, antibacterial dressing. The diverse design of polymer chains self-assembly techniques allow different side secondary structures, enhancing potential. However, the traditional solid powder form polypeptides presents challenges skin applications, shipping, recycling, limiting practical utility. Recent advancements material forming methods polypeptide synthesis have produced biomaterials with uniform, distinct shapes, improving usability. This review outlines progress material-forming over past decade. main include solid-phase ring-opening polymerization N-carboxyanhydrides while like electrospinning, 3D printing, coating explored. Integrating structural these is emphasized, leading to materials unique shapes. also identifies research hotspots using VOSviewer software, which visually presented circular packing images. It further discusses emerging applications such as wound healing, emphasizing crucial role shape performance. concludes by exploring future trends developing shapes advanced encouraging research.
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 370 - 399
Published: Feb. 22, 2025
Language: Английский
Citations
0
Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112361 - 112361
Published: March 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Millions of patients each year are impacted by critical‐size bone tissue defects, the repair which involves inflammation and formation new tissue. In this study, a fractal biomimetic design for 3D‐printed scaffold that combined 3D printing with high‐energy plasma tantalum alloy fabrication, enabling easy production on an industrial scale is proposed. The bionic leverages principles geometry, employing self‐affine patterns random fractals to attain surface scaffolds. This approach aimed emulate dimensions observed in natural structures closely. While roughness implants plays critical role restoration outcomes, findings suggest incorporating dimension may hold greater significance than mere roughness. A rat skull‐defect model utilized assess osteogenic potential three scaffolds, photoacoustic technology first employed long‐term, situ monitoring physiological signals during process. Results from both cell animal experiments demonstrated scaffolds offer notable advantages over surface‐modified experimental results showed group manifested better bone‐promoting
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140225 - 140225
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
The inadequate vascularization and abnormal immune microenvironment in the diabetic bone defect region present a significant challenge to osteogenic regulation. Inspired by distinctive characteristics of healing staged defects structure–function relationship natural periosteum, we fabricated an electrospun bilayer biomimetic periosteum (Bilayer@E) promote regeneration defects. Here, inner layer was using coaxial electrospinning fibers, with shell incorporating zinc oxide nanoparticles (ZnO NPs) core containing silicon dioxide (SiO2 mimicking cambium periosteum; outer consisted randomly aligned fibers loaded deferoxamine (DFO), simulating fibrous finally, epigallocatechin-3-gallate (EGCG) coated onto membrane obtain Bilayer@E. presence EGCG on Bilayer@E surface efficiently triggers phenotypic transition macrophages, shifting them from M1 proinflammatory state M2 anti-inflammatory state. Moreover, sequential release ZnO NPs, DFO, SiO2 NPs exhibits antimicrobial while coordinating angiogenesis promoting mineralization cells. Importantly, shows strong vivo tissue periosteal properties rats. integration drug immunomodulation, tailored meet specific requirements during regeneration, offers new insights for advancing application biomaterials this field.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Abstract Bone defects caused by trauma, infection, or tumors pose significant clinical challenges, particularly in large with poor healing outcomes. Traditional repair methods often fail to address the complex regenerative microenvironment. This study introduces a novel biomimetic piezoelectric periosteum‐bone bilayer implant designed remodel osteogenic microenvironment and enhance bone defect repair. The comprises an upper electrospun polyvinylidene fluoride‐curcumin‐loaded magnesium metal–organic framework (PVDF‐MOF/Cur, PMC) periosteum scaffold lower hydroxyapatite@gelatin methacrylate (HA@GelMA) (PMC+HA@GelMA, PMCG). In whole PMCG implant, PMC improves properties of PVDF enables sustained drug release via Mg‐MOF loaded Cur. Meanwhile, HA@GelMA facilitates marrow mesenchymal stem cells differentiation regeneration. Additionally, further accelerates promoting neuronal differentiation, as well enhancing angiogenesis regulating macrophage polarization. Transcriptome sequencing reveals that activates key signaling pathways associated angiogenesis, neurogenesis, inflammation regulation, osteogenesis, including HIF‐1α, PI3K‐Akt, JAK‐STAT, TGF‐β pathways. Thus, this work highlights multifunctional capabilities remodify accelerate repair, which offers promising platform for advancing tissue
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Abstract The ordered topological micro/nanostructures of scaffolds play a pivotal role in regulating bone development, remodeling, and regeneration. Nevertheless, achieving the integration into 3D remains formidable challenge. In this context, brushing‐assembly strategy is developed to construct bioactive with highly micro/nanostructures. Such an engineered scaffold exhibits positive regulatory effect on behavior fate resident cells, such as mesenchymal stem cells (MSCs) human umbilical vein endothelial (HUVECs), through mechanical stimulation provided by micro/nanostructures, while also allowing for precise spatial distribution multiple cell types assembly. vivo experiments demonstrate that nanostructures possess potential accelerate vascularized Overall, work proposed universal fabrication bridging gap between surface microstructures tissue engineering.
Language: Английский
Citations
0