Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations DOI
Qin Fan,

Bing-Yao Sun,

Jie Chao

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Tetrahedral framework nucleic acids (tFNAs) are renowned for their controllable self-assembly, exceptional programmability, and excellent biocompatibility, which have led to widespread application in the biomedical field. Beyond these features, tFNAs demonstrate unique chemical biological properties including high cellular uptake efficiency, structural bio-stability, tissue permeability, derived from distinctive 3D structure. To date, an extensive range of tFNA-based nanostructures intelligently designed developed various applications such as drug delivery, gene therapy, biosensing, engineering, among other emerging fields. In addition role delivery systems, also possess intrinsic that render them highly effective therapeutic agents treatment complex diseases, arthritis, neurodegenerative disorders, cardiovascular diseases. This dual functionality significantly enhances utility research, presenting valuable opportunities development next-generation medical technologies across diverse diagnostic platforms. Consequently, this review comprehensively introduces latest advancements field, with a focus on benefits nanoplatforms, inherent capabilities agents. Furthermore, current limitations, challenges, future perspectives explored.

Language: Английский

Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy DOI

Xiumei Guo,

Qionghua Zheng,

Wen Gao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123212 - 123212

Published: Feb. 24, 2025

Language: Английский

Citations

2
Drug delivery strategy of hemostatic drugs for intracerebral hemorrhage DOI Creative Commons

Junyan An,

Zhilin Liu, Yihan Wang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 202 - 220

Published: Jan. 10, 2025

Intracerebral hemorrhage (ICH) is associated with high rates of mortality and disability, underscoring an urgent need for effective therapeutic interventions. The clinical prognosis ICH remains limited, primarily due to the absence targeted, precise options. Advances in novel drug delivery platforms, including nanotechnology, gel-based systems, exosome-mediated therapies, have shown potential enhancing management. This review delves into pathophysiological mechanisms provides a thorough analysis existing treatment strategies, emphasis on innovative approaches designed address critical pathological pathways. We assess benefits limitations these offering insights future directions research highlighting transformative next-generation systems improving patient outcomes.

Language: Английский

Citations

1
Multifunctional MnO2 nanosheet based DNA tetrahedron- photosensitizer nanoplatform for gene-photodynamic modulation DOI
Yanlin Zheng, Fei Li, Xiaohui Zhu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159807 - 159807

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations DOI
Qin Fan,

Bing-Yao Sun,

Jie Chao

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Tetrahedral framework nucleic acids (tFNAs) are renowned for their controllable self-assembly, exceptional programmability, and excellent biocompatibility, which have led to widespread application in the biomedical field. Beyond these features, tFNAs demonstrate unique chemical biological properties including high cellular uptake efficiency, structural bio-stability, tissue permeability, derived from distinctive 3D structure. To date, an extensive range of tFNA-based nanostructures intelligently designed developed various applications such as drug delivery, gene therapy, biosensing, engineering, among other emerging fields. In addition role delivery systems, also possess intrinsic that render them highly effective therapeutic agents treatment complex diseases, arthritis, neurodegenerative disorders, cardiovascular diseases. This dual functionality significantly enhances utility research, presenting valuable opportunities development next-generation medical technologies across diverse diagnostic platforms. Consequently, this review comprehensively introduces latest advancements field, with a focus on benefits nanoplatforms, inherent capabilities agents. Furthermore, current limitations, challenges, future perspectives explored.

Language: Английский

Citations

1