Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101422 - 101422
Published: Dec. 24, 2024
Language: Английский
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 648 - 660
Published: Jan. 17, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
Impaired neuronal functions and cell death within ailments such as neurodegenerative Parkinson's disease pose significant challenges due to their complex pathophysiology limited treatment options. In this landscape, innovative materials with unique physicochemical properties that ameliorate the debilitated are critically required. Neuronal rely on conduction of nerve impulses, a process can be effectively targeted using advanced exhibit conducive essential for modulating neural activity. For semiconductor characteristics, combined well-suited biocompatibility, graphitic carbon nitride (g-C3N4) nanosheets provide promising avenues neurotherapeutic applications. Our multidisciplinary study investigates potential g-C3N4 in promoting differentiation network formation across vitro vivo systems. SH-SY5Y cells exposed demonstrated enhanced neuritic outgrowth over chronic 21-days period, accompanied by an increased intracellular Ca2+ influx, pivotal dopamine biosynthesis, evidenced upregulated expression vesicular monoamine transporter 2 (VMAT2), aromatic l-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH) genes. Utilizing transgenic Caenorhabditis elegans model expressing human α-synuclein, we observed neuroprotective g-C3N4, reduced protein aggregation improved dopaminergic functions. pursuit exploring mechanism g-C3N4-induced stimulation, semiconducting nature came forth, which was further validated theoretical (in silico) models. These models increase chemical material upon application electrical biases. Studying channel inhibition, also phenotypic molecular effects were outcomes stimulation caused presence nanosheets. findings, supported experimental silico studies, suggest modulate behavior through properties, offering therapeutic interventions diseases.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 23, 2025
Abstract Spinal cord injury (SCI) constitutes a critical occurrence that results in the disruption of both motor and sensory functions. Oxidative stress‐induced apoptosis pyroptosis have been identified as contributors to neuronal damage during secondary phase following SCI. Therefore, this study focuses on development self‐enhancing drug pair‐driven selenium (Se) nanotherapeutics, loading with 2,3,5,6‐tetramethylpyrazine (TMP) Ginsenoside Rg1 (Rg1), enhance treatment The engineered LET/TMP/Rg1@Se NPs exhibits remarkable antioxidant properties, effectively reducing oxidative by minimizing reactive oxygen species (ROS) accumulation restoring mitochondrial function. In addition their effects, nanotherapeutics demonstrates significant anti‐pyroptotic effects BV2 microglial cells modulating NLRP3/caspase‐1 pathway, leading decreased release pro‐inflammatory cytokines IL‐1β IL‐18. Moreover, inhibition inflammatory cascade response diminishes neuroinflammation‐induced promotes axonal regeneration neurons vitro. mouse model SCI, improved function regeneration, attributed pyroptosis, highlighting scientific basis for synergistic effect Se an innovative strategy effective SCI therapy.
Language: Английский
Citations
0
Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 347 - 347
Published: March 28, 2025
Objective: Because of the evolving nature tissue engineering scaffolds in treatment spinal cord injury (SCI), current study was carried out to evaluate research productivity SCI. Methods: Studies published from 2000 2025 were retrieved Web Science core collection with topics and scaffolds. The data analyzed visualized using VOSviewer network analysis software. Results: Among 1542 articles analyzed, annual publications surged 2019, stabilizing thereafter. U.S., China, Canada led productivity, Northwestern University Biomaterials journal being top contributors. Keyword revealed hotspots such as functional recovery, axonal regeneration, stem cells, hydrogels. Notably, hydrogels embedded genetically engineered cells emerged a pivotal trend, reflecting shift toward biomimetic combinatorial therapies. Collaboration networks highlighted intensified partnerships between Chinese North American institutions, signaling global interdisciplinary efforts. Conclusions: This provides first bibliometric roadmap for SCI, identifying key trends, influential entities, underexplored areas. rise international collaborations underscores opportunities targeted research. These findings guide researchers prioritizing high-impact journals, fostering partnerships, advancing novel scaffold designs bridge translational gaps SCI treatment.
Language: Английский
Citations
0
Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 31, 2025
Spinal cord injury (SCI) with increasing incidence can lead to severe disability. The pathological process involves complex mechanisms such as oxidative stress, inflammation, and neuron apoptosis. Current treatment strategies focusing on the relief of stress inflammation have achieved good effects, while many problems challenges remain side effect short half-life therapeutic agents. Nanozymes exhibiting biocatalytic activities sustainably scavenge free radicals, inhibit neuroinflammation, protect neurons. With high stability in physiological conditions cost-effectiveness, nanozymes provide a new strategy for SCI treatment. In this Review, we outline advances their enzyme-mimicking highlight progress intervention SCI-adopting nanozymes. We also propose future directions clinical translation nanozyme against SCI.
Language: Английский
Citations
0
Science Advances, Journal Year: 2025, Volume and Issue: 11(14)
Published: April 2, 2025
The local delivery of mesenchymal stem cell–derived extracellular vesicles (EVs) via hydrogel has emerged as an effective approach for spinal cord injury (SCI) treatment. However, achieving on-demand release EVs from to address dynamically changing pathology remains challenging. Here, we used a series engineering methods further enhance EVs’ efficacy and optimize their pattern hydrogel. Specifically, the pro-angiogenic, neurotrophic, anti-inflammatory effects were reinforced through three-dimensional culture dexamethasone (Dxm) encapsulation. Then, prepared Dxm-loaded 3EVs (3EVs-Dxm) membrane modified with ortho-dihydroxy groups (-2OH) formed EV-integrated (3EVs-Dxm-Gel) cross-link phenylboronic acid–modified hyaluronic acid tannic acid. ester in 3EVs-Dxm-Gel enabled immobilization reactive oxygen species–responsive EVs. Topical injection SCI rats notably mitigated severity promoted functional recovery, which may offer opportunities EV-based therapeutics central nervous system injury.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101422 - 101422
Published: Dec. 24, 2024
Language: Английский
Citations
3