Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Transition
metal
carbides,
nitrides,
and
carbonitrides
(MXenes)
have
emerged
as
a
promising
class
of
2D
materials
that
can
be
used
for
various
applications.
Recently,
new
form
high-entropy
MXenes
has
been
reported,
which
contains
an
increased
number
elemental
species
increase
the
configurational
entropy
reduce
Gibbs
free
energy.
The
unique
structure
composition
lead
to
range
intriguing
tunable
characteristics.
Herein,
fabrication
MXene
TiVNbMoC
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Engineered
modifications
of
nanomaterials
inspired
by
nature
hold
great
promise
for
disease‐specific
imaging
and
therapies.
However,
conventional
polyethylene
glycol
modification
is
limited
immune
system
rejection.
The
manipulation
gold
nanorods
(Au
NRs)
modified
endogenous
proteins
(eP@Au)
reported
as
an
engineered
biomodulator
enhanced
breast
tumor
therapy.
results
show
that
eP@Au
NRs
neither
activate
inflammatory
factors
in
vitro
nor
elicit
rejection
responses
vivo.
Tumor‐specific
exhibit
a
dual‐modal
capability
trigger
mild
photothermal
effect
under
near‐infrared
light
irradiation,
enabling
highly
efficient
therapy
tumors.
Transcriptome
sequencing
confirmatory
experiments
reveal
the
antitumor
mainly
attributed
to
repression
PI3K‐Akt/MAPK
signaling
pathways
at
molecular
level.
This
powerful
surprising
situ
eP‐regulated
biomodulation
demonstrates
advantages
convenient
fabrication,
inert
immunogenicity,
biocompatibility,
providing
alternative
strategy
biomedical
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Understanding
the
molecular
energy
metabolism
of
single
cells
in
nucleolus
stress
response
induced
by
mild-photothermal
therapy
(mPTT)
is
great
importance
for
investigating
photothermal
lethal
mechanism.
Herein,
we
successfully
fabricated
a
"turn-on"-type
fluorescent
nanoprobe
based
on
fluorescently
labeled
aptamers
(FAM-ATP-apt
and
Cy3-GTP-apt)
Ti3C2TX
MXene.
When
adapters
nanoprobes
bonded
to
intracellular
ATP
GTP,
fluorescence
was
restored.
We
used
monitor
variation
GTP
contents
individual
tumor
normal
during
mPTT.
Interestingly,
found
that
NPM1
translocated
from
nucleoplasm
MCF-7
cancer
within
12
min
mPTT
laser
irradiation,
which
did
not
occur
MCF-10A
cells.
However,
content
changes
treatment
were
significantly
higher
than
The
developed
Ti3C2Tx-ATP/GTP
enables
simultaneous
imaging
living
bioimaging
detection
applications.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
The
development
of
intelligent
nanotheranostic
technology
that
integrates
diagnostic
and
therapeutic
functions
holds
great
promise
for
personalized
nanomedicine.
However,
most
the
agents
exhibit
"always-on"
properties
do
not
involve
an
amplification
step,
which
may
largely
limit
imaging
contrast
restrict
efficacy.
Herein,
we
construct
a
novel
platform
(Hemin/DHPs/PDA@CuS
nanocomposite)
by
assembling
DNA
hairpin
probes
(DHPs)
hemin
on
surface
PDA@CuS
nanosheets
enables
amplified
fluorescence
activatable
chemodynamic
therapy
(CDT)
tumors.
cancer-relevant
APE1
triggers
nucleic
acid
with
DHPs
to
generate
signals
discriminating
cancer
cells
from
normal
cells.
Meanwhile,
excessive
G-quadruplex/hemin-based
DNAzyme
are
also
activated,
they
function
as
Fenton-like
catalysts
catalyze
production
highly
toxic
hydroxyl
radicals
(•OH)
CDT.
Moreover,
owing
excellent
photothermal
conversion
efficiency
in
near-infrared-II
(NIR-II)
window,
only
improves
catalytic
performance
CDT
but
furnishes
PTT.
A
remarkable
antitumor
effect
is
demonstrated
both
vitro
vivo.
Therefore,
Hemin/DHPs/PDA@CuS
nanocomposite
expected
provide
promising
avenue
precise
imaging-guided
therapy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
To
overcome
the
limitations
of
precise
monitoring
and
inefficient
wound
exudate
management
in
healing,
an
advanced
multifunctional
hydrogel
electronics
(MHE)
platform
based
on
MXene@MOF/Fe3O4@C
photonic
crystal
is
developed.
This
combines
optical/electrical
sensing,
synergistic
therapy,
real-time
visual
into
a
single,
efficient
system,
offering
comprehensive
solution
for
healing.
Under
photothermal
stimulation,
releases
metal
ions
that
generate
hydroxyl
radicals,
effectively
eliminating
antibiotic-resistant
bacteria.
Beyond
its
antibacterial
efficacy,
this
system
offers
unprecedented
through
temperature-responsive
visualization,
while
structural
color
changes
upon
absorption
provide
clear
indication
dressing
replacement.
By
integrating
these
functionalities,
MHE
allows
control
therapeutic
process,
significantly
improving
healing
treatment
monitoring.
The
platform's
sensing
capabilities
further
broaden
potential
applications
across
other
biomedical
fields.
breakthrough
technology
provides
clinicians
with
powerful
tool
to
optimize
outcomes,
marking
major
advancement
care
applications.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
Plant
extracellular
vesicles
(PEVs)
are
nanoscale
secreted
by
plant
cells
with
intact
membrane
architecture,
which
encapsulate
a
diverse
array
of
biomolecules,
including
lipids,
proteins
and
RNA.
They
integral
to
both
intra‐cellular
communication
within
plants
inter‐species
signaling.
Recently,
some
PEVs
have
been
regarded
as
competitive
candidates
for
disease
therapy
due
their
beneficial
components
distinctive
hollow
biomembrane
structure.
However,
the
broader
applications
currently
impeded
several
challenges
complicated
extraction
processes,
compositional
heterogeneity,
lack
reliable
biomarkers
unclear
mechanisms.
A
detailed
comprehension
preparation
techniques
biological
functions
is
essential
leveraging
potential
in
clinical
medicine.
This
article
first
presented
synthesis
current
methodologies
PEV
isolation,
purification
characterization.
Then,
it
revealed
therapeutic
implications
medicines
common
diseases
based
on
bioactive
molecules
inside,
such
cancer,
inflammation,
metabolic
disorders.
We
especially
explored
emerging
role
low
immunogenicity
power
barriers
crossing
drug
delivery
systems,
underscoring
further
industry
applications.
At
last,
bottleneck
problems
vision
were
also
evoke
more
insightful
deliberation.
review
aims
provide
directions
development
PEV‐derived
innovative
drugs.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Targeted
delivery
of
glucose
oxidase
(GOx)
using
MXene
remains
a
great
challenge
due
to
its
poor
dispersion
and
susceptibility
oxidation,
the
hypoxia
high
glutathione
(GSH)
contents
make
situation
even
more
worrying.
Herein,
bovine
serum
albumin‐mediated
non‐chemical
modification
strategy
is
developed,
endowing
titanium
carbide
with
long‐time
water‐dispersion
further
integrating
it
as
glycolysis‐controllable
therapy
system
without
any
chemotherapeutic
agents.
The
also
constructs
an
effective
O
2
cycling
GSH
degradation
pathway,
which
fundamentally
adjusts
tumor
microenvironment
greatly
elevates
both
in
vivo
vitro
effects.
Reactive
oxygen
species
are
generated
disrupt
balance
oxidative
stress.
Moreover,
reduced
efficiency
mitochondrial
energy
production
significantly
inhibits
level
glycolysis
hinders
supply.
study
presents
cancer
treatment
combining
starvation/photothermal
therapy,
has
superior
anti‐cancer
effects
dual
reducing
levels
diminishing
cellular
capacity.
