Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Transition
metal
carbides,
nitrides,
and
carbonitrides
(MXenes)
have
emerged
as
a
promising
class
of
2D
materials
that
can
be
used
for
various
applications.
Recently,
new
form
high-entropy
MXenes
has
been
reported,
which
contains
an
increased
number
elemental
species
increase
the
configurational
entropy
reduce
Gibbs
free
energy.
The
unique
structure
composition
lead
to
range
intriguing
tunable
characteristics.
Herein,
fabrication
MXene
TiVNbMoC
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(48), P. 12437 - 12469
Published: Jan. 1, 2024
This
review
summarizes
the
classification
and
methods
for
fabrication
of
emerging
2D
nanomaterials
emphasizes
their
distinctive
properties
biomedical
applications
that
distinguish
them
from
traditional
nanomaterials.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 8681 - 8694
Published: Aug. 1, 2024
Developing
novel
multimodal
nanomaterials-based
anticancer
agents
to
meet
complex
clinical
demands
is
an
urgent
challenge.
This
study
presents
a
uniform
hollow
S-doped
NiCuFe
Prussian
blue
analogue
(NiCuFe-S)
with
satisfactory
size
and
properties
as
for
efficient
cervical
cancer
therapy
using
simple
environmentally
friendly
procedure.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Abstract
Single‐atom
nanotherapies
have
received
numerous
attention
in
malignant
oncotherapy.
However,
the
insufficient
enzyme
substrate
and
upregulation
of
heat
shock
proteins
during
therapeutic
interventions
are
seldom
concurrently
noticed.
Herein,
a
novel
gas
empowered
dual‐cascade
synergistic
treatment
strategy
is
demonstrated
with
domino
effect,
which
can
sequentially
reinforce
single‐atom
nanozyme
(SAzyme)‐based
enzymatic
therapeutics
mild
photothermal
therapy
(PTT)
(<
45
°C).
In
proof‐of‐concept
study,
Fe
single
atom
(Fe/SAzyme)
loaded
hydrogen
sulfide
(H
2
S)
donor
NaHS
developed
for
HSPs‐silencing
mediated
PTT.
The
generated
H
S
suppresses
catalase
activity
to
achieve
“intracellular
O
conservation”,
thereby
furnishing
Fe/SAzyme
produce
abundant
cytotoxic
hydroxyl
radicals
(·OH)
augmented
therapeutics.
Then,
excess
·OH
induced
mitochondrial
dysfunction
blocks
adenosine
triphosphate
(ATP)
energy
supply
realize
cellular
remodeling,
hinders
overexpression
HSPs
enhances
PTT
both
vitro
vivo.
Consequently,
gas‐triggered
achieves
S/·OH/mitochondrial
endowing
SAzymes
maximum
antitumor
efficacy
via
combined
This
dual‐cascaded
gas/enzymatic/mild
oncotherapy
not
only
exhibits
new
pathway
gas‐facilitated
PTT,
but
also
offers
valuable
paradigm
application
“1
+
1
>
3”
multimodal
tumor
therapy.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Transition
metal
carbides,
nitrides,
and
carbonitrides
(MXenes)
have
emerged
as
a
promising
class
of
2D
materials
that
can
be
used
for
various
applications.
Recently,
new
form
high-entropy
MXenes
has
been
reported,
which
contains
an
increased
number
elemental
species
increase
the
configurational
entropy
reduce
Gibbs
free
energy.
The
unique
structure
composition
lead
to
range
intriguing
tunable
characteristics.
Herein,
fabrication
MXene
TiVNbMoC
