The Versatility of Biological Field-Effect Transistor-Based Biosensors (BioFETs) in Point-of-Care Diagnostics: Applications and Future Directions for Peritoneal Dialysis Monitoring DOI Creative Commons

Quan Wang,

Zonghang Zhao,

Ke-Yu Yao

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 193 - 193

Published: March 18, 2025

Peritoneal dialysis (PD) is a vital treatment for end-stage renal disease patients, but its efficacy often compromised by complications such as infections and peritoneal fibrosis. Biological field-effect transistors (BioFETs) present promising solution rapid, sensitive, non-invasive detection of indicators biomarkers associated with these complications, potentially enabling early intervention. However, BioFETs are yet to be adopted PD monitoring. This review presents forward-looking analysis the capacity potential integration into management systems, highlighting their monitor both routine efficiency metabolic status, well specific inflammation We examine challenges in adapting applications, focusing on key areas improvement, including sensitivity, specificity, stability, reusability, clinical integration. Furthermore, we discuss various approaches address challenges, which crucial developing point-of-care (PoC) multiplexed wearable devices. These advancements could facilitate continuous, precise, user-friendly monitoring, revolutionizing complication enhancing patient care.

Language: Английский

Critical Suitability Evaluation of Caco-2 Cells for Gut-on-a-Chip DOI
Xiatong Pan, Jun Chen,

Junlei Han

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(38), P. 51139 - 51149

Published: Sept. 12, 2024

Currently, culturing Caco-2 cells in a Gut-on-a-chip (GOC) is well-accepted for developing intestinal disease models and drug screening. However, were found to overexpress surface proteins (e.g., P-gp) compared with the normal epithelial

Language: Английский

Citations

5
MXene-enhanced detachable transistor neuroprobe for real-time monitoring of serotonin dynamics in human organoids and living brains DOI
Jiahao Li,

Fukang Qi,

Chaoqing Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162542 - 162542

Published: April 1, 2025

Language: Английский

Citations

0
Small-Molecule Self-Assembly Strategy for Ultrafast, Sensitive, and Portable Multiplexed Antibiotics Detection by Transistor Biosensor Arrays DOI
Jiajun Tong, Mengmeng Xiao,

Kemin Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

The urgent need for portable, sensitive, and accurate techniques to analyze multiple antibiotics is critical mitigating the health risks associated with low-dose coexposure-induced drug resistance, especially in infants. Emerging field-effect transistor (FET) biosensors are expected realize above requirement, but face challenges terms of sensitivity selectivity complex solutions practical applications. Here, we introduce a small-molecule coating strategy on carbon nanotube (CNT)-FET biosensor arrays simultaneously block nonspecific adsorption minimize Debye shielding effects, coupled aptamer recognition through inkjet printing technology, which significantly improves sensitivity. developed portable detection system FET chip displayed an ultrafast response time 100 s, high at femtomolar level both simultaneous quantification (kanamycin, oxytetracycline, sulfaquinoxaline), wide linear range from nanomolar concentrations, exceptional accuracy, recovery rate 91.1 107.5%. This work presents array that can quantify various extremely low concentrations milk samples, superior enzyme-linked immunosorbent assay (ELISA) method, also be applied other biomarkers, such as toxins hormones.

Language: Английский

Citations

0
The Versatility of Biological Field-Effect Transistor-Based Biosensors (BioFETs) in Point-of-Care Diagnostics: Applications and Future Directions for Peritoneal Dialysis Monitoring DOI Creative Commons

Quan Wang,

Zonghang Zhao,

Ke-Yu Yao

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 193 - 193

Published: March 18, 2025

Peritoneal dialysis (PD) is a vital treatment for end-stage renal disease patients, but its efficacy often compromised by complications such as infections and peritoneal fibrosis. Biological field-effect transistors (BioFETs) present promising solution rapid, sensitive, non-invasive detection of indicators biomarkers associated with these complications, potentially enabling early intervention. However, BioFETs are yet to be adopted PD monitoring. This review presents forward-looking analysis the capacity potential integration into management systems, highlighting their monitor both routine efficiency metabolic status, well specific inflammation We examine challenges in adapting applications, focusing on key areas improvement, including sensitivity, specificity, stability, reusability, clinical integration. Furthermore, we discuss various approaches address challenges, which crucial developing point-of-care (PoC) multiplexed wearable devices. These advancements could facilitate continuous, precise, user-friendly monitoring, revolutionizing complication enhancing patient care.

Language: Английский

Citations

0