Polyphenol-Protein Particles: A Nutraceutical Breakthrough in Nutrition and Food Science

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101641 - 101641

Published: Jan. 1, 2025

Language: Английский

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Cellulose-mediated mechanical property tuning in small intestinal submucosal matrix to enhance stem cell osteogenic differentiation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139575 - 139575

Published: Jan. 8, 2025

Language: Английский

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Fuh@Decm Hydrogel Delays Intervertebral Disc Degeneration Through Macrophage Reprogramming and Antioxidant Properties

Published: Jan. 1, 2025

1.Abstract Key pathological factors contributing to intervertebral disc degeneration (IVDD) include excessive production of reactive oxygen species (ROS), depletion the extracellular matrix (ECM), and an imbalance in M1/M2 macrophage ratio. To address these challenges, we developed a novel bioactive hydrogel (FUH@dECM) by integrating high-concentration fucoidan (FU) with decellularized (dECM). This is designed for situ injection, where it undergoes gelation at site administration, replenishing lost ECM nucleus pulposus cells while gradually releasing FU. In vitro, experiments demonstrated that controlled release FU effectively scavenges ROS, promotes polarization towards M2 phenotype, restores metabolic balance. RNA sequencing analysis revealed antioxidant effects FUH@dECM are primarily mediated through activation FOXO signaling pathway, inhibition NF-κB pathway mitigates inflammatory response. vivo rat model IVDD, this system strong mechanistic alignment physiological processes disc, significantly improving IVDD outcomes maintaining height preserving structural integrity tissue. These results underscore potential as promising therapeutic strategy treatment IVDD.

Language: Английский

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Cubosomes-based hydrogels; A promising advancement for drug delivery

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125510 - 125510

Published: March 1, 2025

Language: Английский

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Probiotic Membrane-Modified Nanocomposite Alleviates Inflammation and Microbiota Dysbiosis in Colitis by Scavenging Oxidative Stress and Restoring Immune Homeostasis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Inflammatory bowel disease (IBD) is a complex chronic intestinal disorder in which excessive oxidative stress, dysregulated immune response, and microbiota dysbiosis contribute to recurrent episodes of inflammation the colonic mucosa. Current clinical treatments focusing solely on resolution often exhibit limited efficacy due inability fundamentally improve pathological microenvironment. Herein, probiotic membrane-modified drug delivery nanocomposite, namely, MPDA@Cur@EM, developed for comprehensive treatment IBD. It contains two components: curcumin-loaded mesoporous polydopamine nanoparticle (MPDA@Cur) as core Escherichia coli Nissle 1917 outer membrane (EM) surface. For MPDA@Cur, microenvironment triggers responsive release curcumin. Importantly, MPDA@Cur can effectively alleviate inflammatory response LPS-activated macrophages through MPDA-mediated ROS scavenging curcumin-induced M2 polarization. In dextran sulfate sodium (DSS)-induced colitis model, EM coating not only allows targeting enrichment orally administered MPDA@Cur@EM inflamed mucosa, but also participates regulation flora. Consequently, efficiently attenuates reaction restores barrier functions, demonstrated by multipronged manner restoring redox balance, remodeling homeostasis, reshaping gut microecology. Collectively, this work provides safe promising codelivery strategy product, antioxidative nanoenzyme, therapeutic management

Language: Английский

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Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Well‐integration of multiple bioactive components into a biological patch without damaging its cellular matrix structure is crucial for infectious abdominal wall defect repair but remains challenging. Herein, novel asymmetric composite (bPVA/SIS + ‐NP) developed by in situ introducing zwitterionic polyvinyl alcohol molecular brush (bPVA) hydrogel to cationic small intestinal submucosal decellularized (SIS ) via self‐induced phase separation based united strategy. Due high hydrogen bonding crosslinking and strong mechanical interlocking with SIS ‐NP layer, bPVA layer can maintain stable anti‐contamination the corresponding anti‐adhesion properties contaminated environment. On basis preserving an original extracellular skeleton, show contact anti‐bacterial ability at acute stage together prolonged drug release during healing repair. Furthermore, combination layers lead burst pressure tolerance. By comprehensive control bacteria their necrotic products, bPVA/SIS achieve anti‐infection, anti‐adhesion, pro‐healing on rats. Therefore, opens new avenue bio‐friendly construction multifunctional patches address stringent requirements

Language: Английский

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Thermosensitive poly (NVCL-co-GelMA) nanogels as a delivery platform for rectal administration of 5-ASA in ulcerative colitis

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162442 - 162442

Published: April 1, 2025

Language: Английский

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Encapsulation of Enterococcus faecium in hyaluronic acid/gelatin/sodium alginate/protamine improves cell viability and stability

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142948 - 142948

Published: April 1, 2025

Language: Английский

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Hydrogel derived from decellularized pig small intestine submucosa boosted the therapeutic effect of FGF-20 on TNBS-induced colitis in rats via restoring gut mucosal integrity

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101783 - 101783

Published: April 1, 2025

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by impaired intestinal mucosal barrier function, leading to persistent inflammation and tissue damage. Current therapies often fail address dysfunction, highlighting the need for innovative treatments. This study developed novel therapeutic strategy combining decellularized porcine small submucosa (D-SIS) with fibroblast growth factor 20 (FGF-20) promote repair restore integrity in TNBS-induced rat model. The D-SIS-based hydrogel, supplemented hyaluronic acid (HA), was designed enhance FGF-20 stability enable sustained drug release. Results showed that FGF-20-loaded hydrogel (MAF) exhibited excellent rheological properties, erosion resistance, controlled release, making it suitable rectal administration. In vitro cell experiments demonstrated MAF enhanced Caco-2 proliferation, migration, tight junction protein expression, restoring epithelial integrity. model, significantly reduced activity index (DAI) scores, attenuated inflammation, restored morphology. Additionally, promoted goblet regeneration, mucus secretion, upregulated stem markers, indicating its ability both barriers. conclusion, represents promising approach UC regenerative properties of bioactive support D-SIS.

Language: Английский

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Innovative approaches to tissue engineering: Utilizing decellularized extracellular matrix hydrogels for mesenchymal stem cell transport

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 290, P. 138893 - 138893

Published: Dec. 18, 2024

Language: Английский

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