Bioprinting, Journal Year: 2024, Volume and Issue: unknown, P. e00373 - e00373
Published: Nov. 1, 2024
Language: Английский
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 207 - 207
Published: March 15, 2025
Hydrogels are innovative materials characterized by a water-swollen, crosslinked polymeric network capable of retaining substantial amounts water while maintaining structural integrity. Their unique ability to swell or contract in response environmental stimuli makes them integral biomedical applications, including drug delivery, tissue engineering, and wound healing. Among these, “smart” hydrogels, sensitive such as pH, temperature, light, showcase reversible transitions between liquid semi-solid states. Thermoresponsive exemplified poly(N-isopropylacrylamide) (PNIPAM), particularly notable for their sensitivity temperature changes, transitioning near lower critical solution (LCST) approximately 32 °C water. Structurally, PNIPAM-based hydrogels (PNIPAM-HYDs) chemically versatile, allowing modifications that enhance biocompatibility functional adaptability. These properties enable application diverse therapeutic areas cancer therapy, phototherapy, healing, engineering. In this review, the behavior smart PNIPAM explored, with an emphasis on synthesis methods brief note biocompatibility. Furthermore, PNIPAM-HYDs detailed, along applications skin conditions, ocular diseases, etc. Various delivery routes patents highlighting advancements also examined. Finally, future prospects remain promising, ongoing research focused enhancing stability, responsiveness, clinical applicability. continued development is expected revolutionize technologies, paving way more efficient targeted solutions.
Language: Английский
Citations
0
Nature Reviews Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Language: Английский
Citations
0
Materials, Journal Year: 2025, Volume and Issue: 18(7), P. 1614 - 1614
Published: April 2, 2025
Poly(N-isopropylacrylamide) (PNIPAm) undergoes a sharp phase transition in aqueous solutions at around 32 °C, which is called the lower critical solution temperature; tuning of LCST PNIPAm could be achieved by copolymerization N-isopropylacrylamide (NIPAm) with other hydrophilic/hydrophobic monomers to regulate solvation state and meet requirements possible applications. Herein, hydrophilic monomer, 2,3-dihydroxypropyl methacrylate (DHPMA), w introduced behavior via free radical copolymerization. A series poly(N-isopropylacrylamide-co-2,3-dihydroxypropyl methacrylate) (P(NIPAm-co-DHPMA)) was synthesized characterized. The reaction kinetics were investigated detail. In this copolymerization, reactivity ratios DHPMA NIPAm found 3.09 0.11, suggesting that had greater preference for homopolymerization than while homopolymerization. temperature P(NIPAm-co-DHPMA) copolymers varied from 31 42 °C controlling content 0 58 mol%. Finally, good cytocompatibility confirmed. These results provide insights into designing thermo-responsive polymers suitable responsive behaviors different
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Abstract Fabricating hydrogel‐based channels with diameters below 200 µm remains challenging in advanced vitro modeling and tissue engineering. To address this challenge, thermoshrinkable hydrogels that undergo reversible isotropic dimensional changes temperature are developed. A thermoresponsive polymer methacrylate groups (PNH‐MA) is synthesized from polyethylene glycol (PEG), N–isopropylacrylamide (NIPAM), 2‐hydroxyethyl acrylate (HEA), enabling photo‐cross‐linking precise material tuning. PNH‐MA can shrink up to 90% volume (50% diameter) remain transparent allowing cellular imaging. In a four‐dimension (4D) fabrication strategy, seeded proximal tubule epithelial cells shrunk reduce diameters. Using pin pull‐out mold casting, of 120 410 65 µm, respectively. While needle injection for smaller than volumetric printing addresses limitation. The shrinkage properties enable leak‐proof perfusion, cell seeding continuous unilateral flow as small 100170 µm. polymers represent one the few examples low‐viscosity resins successfully used hydrogel complex scaffolds. This study highlights potential scalable, high‐precision tubular scaffold modeling.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 5, 2025
Abstract The multi‐territory perforator flap is a widely used microsurgical technique for repairing skin and tissue defects in diabetes. In the diabetic microenvironment, oxidative stress inflammation from reactive oxygen species (ROS) lead to compromised blood supply flap, resulting challenges survival. common complication of distal necrosis, which primarily attributed Choke zone, critical location characterized by delayed inadequate neovascularization. To address this issue, ROS‐responsive MSL@Z/G hydrogel developed encapsulating metformin‐Sr‐L‐Arg@ZIF‐90 (MSL@Z) nanoparticles into gelatine methacrylamide (GelMA), enabling release metformin, Sr ions NO. enhanced deformation resistance compressive strength properties make it suitable reconstruction drug delivery. Additionally, exhibits antioxidant anti‐inflammatory effects, thereby modulating vascular microenvironment. dorsal perforated model type 2 rats, demonstrates ability alleviate promote neovascularization reducing holds great promise improving survival
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
Abstract The availability of realistic in vitro models is crucial for tissue engineering, disease modeling, and drug screening assays. However, reproducing the complex shapes intricate structures naturally occurring tissues or organs presence functional cells remains a challenge. For example, it still not trivial to obtain cell‐laden tubular on micrometer scale present nephrons human kidney. Here, unique hydrogel‐based shrinking approach making use host–guest interactions decrease diameters preformed hydrogel tubules seeded with proposed as tool overcome abovementioned hydrogels are composed covalently crosslinked methacrylated hyaluronic acid dextran modified either cyclodextrin adamantane groups that can form dynamic bonds. initially formed small‐molecule competitors block any interpolymer interactions, process triggered by release these competitor molecules. high efficiency factor up eight times volume robust cytocompatibility make host‐guest‐based an appealing desired dimensions demand.
Language: Английский
Citations
3
Bioprinting, Journal Year: 2024, Volume and Issue: unknown, P. e00373 - e00373
Published: Nov. 1, 2024
Language: Английский
Citations
3