High‐Valence Selenium Nanotherapeutics Downregulates MUC16 to Drive Precise Ovarian Cancer Therapy through Redox Perturbation DOI Open Access
Xiaoli Hu, Zhongwen Yuan, Guanning Huang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Abnormal expression of transmembrane mucin 16 (MUC16) in ovarian cancer (OC) can promote progression epithelial–mesenchymal transformation, enhance tumor cell proliferation, migration, and invasion. Therefore, herein a targeted therapeutic high‐valence selenium (Se) nanomedicine (MUC16‐SeMnf@Res) is designed, which target MUC16 to recognize OC simultaneously inhibit achieve efficient treatment OC. The valence bidirectional editing strategy used design synthesize Se nanosystem (SeMnf) through triggering redox reaction between triclinic manganese dioxide nanoflower (Mnf), inducing the conversion 4+ Mn 2+ . increased ratio within SeMnf disrupt intracellular homeostasis by glutathione (GSH) depletion reactive oxygen species (ROS) overproduction. Moreover, effects ROS overproduction are further amplified loaded resveratrol (Res), significantly induces mitochondrial dysfunction inhibited expression, then promoting caspase‐activated apoptosis as well migration inhibitory. Taken together, this study not only sheds light on important role designing OC‐targeting drugs, but also provides simple translational developing nanotherapeutics with strong redox‐homeostasis disrupting capability realize MUC16‐targeting therapy.

Language: Английский

High‐Valence Selenium Nanotherapeutics Downregulates MUC16 to Drive Precise Ovarian Cancer Therapy through Redox Perturbation DOI Open Access
Xiaoli Hu, Zhongwen Yuan, Guanning Huang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Abnormal expression of transmembrane mucin 16 (MUC16) in ovarian cancer (OC) can promote progression epithelial–mesenchymal transformation, enhance tumor cell proliferation, migration, and invasion. Therefore, herein a targeted therapeutic high‐valence selenium (Se) nanomedicine (MUC16‐SeMnf@Res) is designed, which target MUC16 to recognize OC simultaneously inhibit achieve efficient treatment OC. The valence bidirectional editing strategy used design synthesize Se nanosystem (SeMnf) through triggering redox reaction between triclinic manganese dioxide nanoflower (Mnf), inducing the conversion 4+ Mn 2+ . increased ratio within SeMnf disrupt intracellular homeostasis by glutathione (GSH) depletion reactive oxygen species (ROS) overproduction. Moreover, effects ROS overproduction are further amplified loaded resveratrol (Res), significantly induces mitochondrial dysfunction inhibited expression, then promoting caspase‐activated apoptosis as well migration inhibitory. Taken together, this study not only sheds light on important role designing OC‐targeting drugs, but also provides simple translational developing nanotherapeutics with strong redox‐homeostasis disrupting capability realize MUC16‐targeting therapy.

Language: Английский

Citations

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