Sweat‐Permeable, Microbiota‐Preserving, Mechanically Antibacterial Patch for Long‐Term Interfacing with Perspiring Skin DOI Open Access

Yujiao Wu,

Xinyu Li,

Peiying He

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract The prolonged health monitoring using wearable technology faces challenges stemming from perspiration, including bacterial proliferation, compromised adhesion, signal quality deterioration, and user discomfort. Notably, excessive sweat fosters colonization, escalating infection risks, compromising biomarker analysis. Existing antibacterial approaches, unfortunately, risk disrupting the delicate balance of skin microbiota. To address this, a Janus patch featuring Zn‐Al layered double hydroxide (LDH) modification is developed, which exhibits sustained properties while preserving epidermal microecology. It integrates hydrophilic LDH fabric that mechanically eradicates bacteria via nanoknife effect, laser‐engraved medical adhesive with microholes for unidirectional transport. This innovative design not only enhances adhesion stability but also safeguards microbiome by preventing direct contact LDH. Moreover, seamlessly interfaces sweat‐monitoring technologies like microfluidic paper‐based analytical devices (uPADs) sensors, ensuring 100% efficacy efficient redirection reliable detection prioritizing comfort. can serve as durable bridge between perspiring revolutionizing realm long‐term monitoring.

Language: Английский

Multifunctional dynamic chitosan-guar gum nanocomposite hydrogels in infection and diabetic wound healing DOI

Luning He,

Xing Shen, Weikang Zhang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123316 - 123316

Published: Jan. 1, 2025

Language: Английский

Citations

2
Construction of multifunctional gauze via the potassium permanganate method for wound management DOI
Wei Zhang,

Qiang Niu,

Yuyang Cheng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161541 - 161541

Published: March 1, 2025

Language: Английский

Citations

0
IR820 Sensitized Ceria Nanozyme via PDA Bridging for Multifaceted Antibacterial Wound Healing Therapy DOI Open Access
Akram Nasser Juaim, Jiao Sun, Ran Nie

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Nanozymes with peroxidase (POD)-like activity hold significant potential for addressing antibiotic-resistant bacterial infections. However, their catalytic efficiency and therapeutic efficacy need further improvement to broaden clinical applications. A key challenge is achieving efficient energy transfer from photosensitizing molecules nanozymes, which critical enhancing performance. In this study, a universal strategy developed bridge nanozymes molecules, designing photoactivated called IR820/PDA@mCeO2 (IR/P@Ce). By integrating IR820, photosensitizer, mesoporous ceria (mCeO2), it facilitates electron through polydopamine (PDA) resulting in enhanced POD-like performance reactive oxygen species production. Additionally, PDA stabilized the nanozyme, improved photothermal therapy, photodynamic therapy under near-infrared light exposure, amplifying destruction. This multifunctional nanozyme demonstrated strong antibacterial against both Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli) bacteria. Moreover, its synergistic approach not only facilitated eradication but also accelerated wound healing vivo, making promising alternative managing infections promoting tissue regeneration.

Language: Английский

Citations

0
NIR responsive microneedles patch used for promoting spinal cord injury repair by modulating mitochondrial ROS microenvironment DOI

Shuangshuang Chen,

Zelin Sang,

Yumei Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162247 - 162247

Published: April 1, 2025

Language: Английский

Citations

0
Constructing Reinforced Flexible Wood-Based Hydrogels Leveraging the Ordered Structure of Wood for Potential Wound Treatment DOI
Zhang We, Wenxiang Zhai, Min Xu

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
3D‐Printed Hydrogel Patches Embedded with Cu‐Modified Liquid Metal Nanoparticles for Accelerated Wound Healing DOI
Bo Wang,

Xiaohui Shan,

Jianye Gao

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Wound healing is significantly challenged by resistant bacterial infections. Gallium‐based liquid metal (LM) antibacterial agents show promise due to their non‐inducement of resistance, though efficacy remains limited. Here, we graft copper onto nano‐LM surfaces via ultrasonication create copper‐modified LM nanoparticles (Cu‐LMNPs) with enhanced properties. Specific experiments suggest that Cu‐LMNPs enhance against ampicillin‐resistant Escherichia coli ( E. ) and methicillin‐resistant Staphylococcus aureus MRSA in vitro, achieving ≈100% effectiveness. The remarkable stems from the considerable increase Cu 2 ⁺ Ga 3 concentrations. Further, epidermal growth factors (EGF) are incorporated into rheology‐tunable hydrogels excellent printability biocompatibility for accelerating chronically infected wound healing. In vivo demonstrate hydrogel patches effectively treated ‐infected wounds mice. Sustained release multiple ions EGF promotes epithelial regeneration, collagen deposition, neovascularization, making markedly distinct control group nearly fully healed within 10 days. Overall, this research presents a novel 3D‐printed mesh patch not only combats infections but also accelerates

Language: Английский

Citations

0
High Self‐Supporting Chitosan‐Based Hydrogel Ink for In Situ 3D Printed Diabetic Wound Dressing DOI Open Access
Shanshan Li, Yidi Xu,

Lu Zheng

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 13, 2024

Abstract Customizable 3D‐printed biopolymer hydrogels, highly sought after for diabetic wound management, face challenges in clinical application due to weak physical crosslinking within their constituent inks. In this study, a novel chitosan‐based hydrogel ink with dense yet reversible network is subtly designed the rapid situ fabrication of personalized dressing. This robust established through multiple electrostatic and hydrogen bonding interactions between unique carboxymethyl chitosan nanoclay, further reinforced by introduction amide bonds, which act as double bond donors/acceptors. Benefiting from network, low nanoclay content exhibits remarkable self‐supporting properties, enabling high‐fidelity, large‐scale, complex 3D printability without additional processing, while substantially retaining its inherent rheological properties autoclave sterilization incorporation active components. Given these advantages, multifunctional printable can be rapidly constructed on wounds. Simultaneously, demonstrates biodegradability, anti‐swelling, appropriate mechanical along vitro antibacterial pro‐angiogenic capabilities, leading effective healing vivo. work offers new strategy creating inks paves way developing advanced dressings.

Language: Английский

Citations

3
“On-demand” nanosystem-integrated microneedles for amplified triple therapy against recalcitrant bacteria and biofilm growth DOI Creative Commons
Ting Wen, Yiting Zhao, Yànpíng Fù

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101327 - 101327

Published: Nov. 6, 2024

Phototherapy has emerged to eradicate recalcitrant bacteria without causing drug resistance, but it is often accompanied by considerable limitations owing a high tolerance of heat and oxidative damage, leading low efficiency monotherapy unwanted side effects. Assuming that employing antimicrobial peptides (AMPs) disrupt bacterial membranes could reduce tolerance, multifunctional "on-demand" nanosystem based on zeolitic imidazolate framework-8 (ZIF-8) with metal ions for intrinsic antibacterial activity was constructed potently kill methicillin-resistant

Language: Английский

Citations

2
Sweat‐Permeable, Microbiota‐Preserving, Mechanically Antibacterial Patch for Long‐Term Interfacing with Perspiring Skin DOI Open Access

Yujiao Wu,

Xinyu Li,

Peiying He

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract The prolonged health monitoring using wearable technology faces challenges stemming from perspiration, including bacterial proliferation, compromised adhesion, signal quality deterioration, and user discomfort. Notably, excessive sweat fosters colonization, escalating infection risks, compromising biomarker analysis. Existing antibacterial approaches, unfortunately, risk disrupting the delicate balance of skin microbiota. To address this, a Janus patch featuring Zn‐Al layered double hydroxide (LDH) modification is developed, which exhibits sustained properties while preserving epidermal microecology. It integrates hydrophilic LDH fabric that mechanically eradicates bacteria via nanoknife effect, laser‐engraved medical adhesive with microholes for unidirectional transport. This innovative design not only enhances adhesion stability but also safeguards microbiome by preventing direct contact LDH. Moreover, seamlessly interfaces sweat‐monitoring technologies like microfluidic paper‐based analytical devices (uPADs) sensors, ensuring 100% efficacy efficient redirection reliable detection prioritizing comfort. can serve as durable bridge between perspiring revolutionizing realm long‐term monitoring.

Language: Английский

Citations

1