Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Language: Английский
Biomaterials Research, Journal Year: 2025, Volume and Issue: 29
Published: Jan. 1, 2025
Tendon/ligament-bone junctions (T/LBJs) are susceptible to damage during exercise, resulting in anterior cruciate ligament rupture or rotator cuff tear; however, their intricate hierarchical structure hinders self-regeneration. Multiphasic strategies have been explored fuel heterogeneous tissue regeneration and integration. This review summarizes current multiphasic approaches for rejuvenating functional gradients T/LBJ healing. Synthetic, natural, organism-derived materials available vivo validation. Both discrete gradient layouts serve as sources of inspiration organizing specific cues, based on the theories biomaterial topology, biochemistry, mechanobiology, situ delivery therapy, which form interconnected network within design. Novel engineering can be constructed by electrospinning, 3-dimensional printing, bioprinting, textiling, other techniques. Despite these efforts being limited at present stage, scaffolds show great potential precise reproduction native T/LBJs offer promising solutions clinical dilemmas.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
The advancement of controllable mineral adhesion materials has significantly impacted various sectors, including industrial production, energy utilization, biomedicine, construction engineering, food safety, and environmental management. Natural biological exhibit distinctive properties that inspire the design artificial systems for controlling adhesion. In recent decades, researchers have sought to create bioinspired effectively regulate adhesion, accelerating development functional across emerging fields. Herein, we review advances in mineralized antiscaling materials. First, a systematic overview nature is provided. Then, mechanism latest characterization between minerals material surfaces are introduced. Later, designed presented, ranging from molecular level micro/nanostructures, Additionally, applications these fields discussed, such as management, highlighting their roles promoting or inhibiting aspects. Finally, summarize ongoing challenges offer perspective on future this charming field.
Language: Английский
Citations
0
Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112361 - 112361
Published: March 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Osteochondral defects are common orthopedic conditions that can lead to osteoarthritis and severe joint pain. Recently, smart biohydrogels have been widely applied in osteochondral repair regeneration, owing their 3D structural resemblance tissues remarkable responsiveness external stimuli. Glucosamine hydrochloride (GH) has proved stimulate the proliferation chondrogenic differentiation of bone mesenchymal stem cells (BMSC), thereby accelerating wound healing tissue regeneration. Herein, double‐crosslinked hydrogels SPA 5 ‐Mg/GH/FP fabricated using sodium alginate, acrylamide N‐Isopropylacrylamide (NIPAM) as substrates. Simultaneously, incorporation Mg 2+ Polydopamine (PDA)‐coated Fe 3 O 4 NPs into system further enhanced its properties. The results emphasized favorable microenvironment created by architecture hydrogel, which effectively facilitated regeneration defects. Notably, controlled release GH aligned with process is achieved through @PDA near‐infrared light. Moreover, vivo assessments demonstrated effectiveness hydrogel repairing defects, highlighting similarities native tissue. This promising outcome underscores potential a sophisticated solution for addressing challenges associated repair.
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 608 - 626
Published: March 29, 2025
Language: Английский
Citations
0
Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101737 - 101737
Published: April 1, 2025
Osteochondral scaffolds designed with bi-phasic and multi-phasic have typically struggled post-implantation delamination. To address this issue, we developed a novel integrated scaffold natural continuous interface heterogeneous bilayer structure. Through layer-by-layer wet electrospinning, two-dimensional (2D) bi-layer membranes of silk fibroin (SF) polycaprolactone (PCL) were fabricated. These then transformed into three-dimensional (3D) using CO2 gas foaming technique, followed by gelatin coating on the osteogenic layer to afford final porous scaffolds. In vitro studies indicated that 3D better-maintained cell phenotypes than conventional 2D electrospun films. Additionally, showed superior cartilage repair osteoinductivity potential, increased subchondral bone volume reduced defect area in rat osteochondral defects models at 12 weeks. Taken together, these gas-foamed promising candidate for regeneration.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101775 - 101775
Published: April 18, 2025
Language: Английский
Citations
0
Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Language: Английский
Citations
0