Nanocarriers for cutting-edge cancer immunotherapies
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Language: Английский
Nanoarchitectonics for Pentagon Defects in Carbon: Properties and Catalytic Role in Oxygen Reduction Reaction
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
Abstract
The
oxygen
reduction
reaction
(ORR)
is
a
crucial
process
in
electrochemical
energy
technologies,
featuring
fuel
cells
and
metal‐air
batteries
the
coming
carbon‐neutral
society.
Carbon
materials
have
garnered
significant
attention
as
economical,
sustainable
alternatives
to
precious
metal
catalysts.
In
particular,
there
been
increasing
reports
recently
that
pentagons
introduced
into
graphitic
carbons
promote
catalytic
activity
for
ORR.
addition,
interesting
studies
are
reported
on
carbon
materials’
synthesis,
characterization,
spin
polarization
properties
with
pentagonal
defects.
This
review
comprehensively
summarizes
formation
mechanism,
spin,
(O
2
)
adsorption,
ORR
of
catalysts
By
connecting
dots
between
theoretical
insights
experimental
results,
this
elucidates
fundamental
principles
governing
pentagon‐related
offers
perspectives
future
directions
designing
efficient
based
materials.
Language: Английский
Mass Spectrometry Imaging Reveals the In Situ Distribution and Metabolic Effects of Fullerenes
Yijiao Qu,
No information about this author
Jing Han,
No information about this author
Ruiyue Wang
No information about this author
et al.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Fullerene-based
nanoparticles
have
been
extensively
developed
and
applied
in
biological
immunotherapy
due
to
their
unique
immunomodulatory
properties.
However,
current
methods
for
investigating
biodistribution
predominantly
rely
on
fluorescent
labeling,
which
limits
our
understanding
of
the
true
fullerenes
at
both
organ
suborgan
levels,
as
well
impact
organ-specific
metabolism.
In
this
study,
we
utilized
laser
desorption
ionization
matrix-assisted
desorption/ionization
mass
spectrometry
imaging
achieve
simultaneous
vivo
mapping
associated
metabolites.
Following
tail-vein
injection
into
mice,
were
primarily
localized
liver
spleen
with
significant
enrichment
red
pulp
spleen.
Notably,
fullerene
accumulation
normal
tissues
resulted
substantial
alterations
endogenous
metabolic
pathways,
particularly
those
related
pyrimidine,
purine,
energy
This
approach
provides
valuable
insights
effects
vivo,
offering
a
foundation
further
investigation
therapeutic
implications.
Language: Английский
Advances in photothermal therapy for cancer and bacterial cells ablation using various nanomaterials
Advances in Colloid and Interface Science,
Journal Year:
2025,
Volume and Issue:
342, P. 103541 - 103541
Published: May 1, 2025
Language: Английский
The Application of Nanomaterials in the Treatment of Pancreatic-Related Diseases
Jing Ma,
No information about this author
Xue Li,
No information about this author
Chunru Wang
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13158 - 13158
Published: Dec. 7, 2024
Pancreatic
diseases,
typically
including
pancreatic
cancer,
pancreatitis,
and
diabetes,
pose
enormous
threats
to
people's
lives
health.
To
date,
therapeutics
with
high
therapeutic
efficacy
low
side
effects
are
still
challenging.
With
the
development
of
nanotechnology,
nanomaterials
have
successfully
been
applied
in
pancretic
disease
treatment.
Here,
we
first
introduce
diversity
their
different
physicochemical
properties
on
function.
Following
this,
analyze
potential
enhance
targeting
by
overcoming
challenges
traditional
delivery
methods
through
surface
modifications,
structural
adjustments,
optimized
drug
loading.
Then,
application
structurally
pancreatic-related
diseases.
For
instance,
cancer
(as
platforms,
for
promotion
radiation
therapy,
as
multifunctional
tools),
pancreatitis
systems,
anti-inflammatory
anti-fibrotic
agents),
diabetes
insulin
carriers,
protecting
β
cells,
improving
resistance).
Through
analysis
progress
current
research,
summarize
how
can
treatment
while
minimizing
effects.
Finally,
look
forward
prospects
Language: Английский