Cu-Doped MnO₂ Nanoparticles Loaded with Docetaxel Synergistically Enhance Chemodynamic Therapy through Ferroptosis and Cuproptosis

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We have developed an innovative Cu-doped and DTX-loaded Cu-MnO2@DTX@FA (MCDF) nanodrug designed to strategically alter tumor microenvironment (TME) by harnessing the synergistic effects of chemodynamic therapy (CDT), chemotherapeutic agents, induction ferroptosis cuproptosis. The MCDF efficiently degrades, releasing abundant Mn4+, Cu2+, DTX. conversion Cu2+ Cu+ facilitated FDX1 initiates cuproptosis, while, similar Mn2+, reacts with hydrogen peroxide (H2O2) generate hydroxyl radicals (·OH). Mn4+ oxidize glutathione (GSH), significantly depleting GSH levels in cells inactivating GPX4, which further promotes ferroptosis. release intensifies DTX effectively disrupts cell division cycle, thereby inhibiting proliferation spread cells. FA-modified is evade immune detection while selectively targeting tissues, ensuring precision treatment delivery. This cutting-edge material not only provides a multifunctional therapeutic strategy but also sets stage for next generation tumor-targeting nanomedicines.

Language: Английский

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Mesoporous dual-atom nanozyme induced cuproptosis and apoptosis for boosting immunogenic cell death along with reprogramming tumor immune-suppressive microenvironment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160294 - 160294

Published: Jan. 1, 2025

Language: Английский

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Structure, synthesis and application of carbon based double single atom catalysts

Desalination, Journal Year: 2025, Volume and Issue: 606, P. 118762 - 118762

Published: March 3, 2025

Language: Английский

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