ATP‐Triggered Ultrafine Iron Oxide Nanowires for Self‐Monitoring Tumor Therapy by T1‐Magnetic Resonance Imaging‐Guided •OH Generation DOI
Zhengtao Xu,

Chen Wang,

Zhuangzhuang Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Theranostic probes that integrate diagnosis and treatment together are considered as effective tools for individual therapy. However, the separation of detection components limits precise assessment therapeutic efficacy. Herein, a novel self‐monitoring probe sensitively responds to adenosine triphosphate (ATP) was developed by ultrafine iron oxide nanowires (UIONWs) through an oleyl amine‐assisted way. The UIONWs, with diameter 1.5 nm length 75 nm, surface‐coordinated amine. UIONWs can be decomposed in ATP‐containing solution expose shielded ions. Consequently, it boost peroxidase (POD) activity activate T 1 ‐magnetic resonance imaging (MRI) signal ATP. In addition, rapidly engulfed into cells due high aspect ratio. improved ATP hydrogen peroxide (H 2 O ) within tumor leads higher hydroxyl radicals (OH) generation inhibition.In contrast, normal exhibit lower H levels, reducing cytotoxicity ensuring safety. Since both illumination ‐MRI OH ATP‐controlled, this work raised potential way self‐monitor therapy timely feedback on effects.

Language: Английский

Combating cancer immunotherapy resistance: a nano‐medicine perspective DOI Creative Commons
Xiangyi Kong, Xintong Xie, Juan Wu

et al.

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading resistance. Various functionalized nanoparticles (NPs), modified with cationic lipids, pH‐sensitive compounds, or photosensitizers, exhibit unique physicochemical properties facilitate targeted delivery therapeutic agents tumor microenvironment (TME). These NPs are engineered modify activity. The crucial signal transduction pathways by which counteract resistance outlined, including enhancing antigen presentation, boosting activation infiltration tumor‐specific cells, inducing immunogenic cell death, counteracting immunosuppressive conditions in TME. Additionally, review summarizes current clinical trials involving NP‐based immunotherapy. Ultimately, it highlights potential nanotechnology advance

Language: Английский

Citations

0
ATP‐Triggered Ultrafine Iron Oxide Nanowires for Self‐Monitoring Tumor Therapy by T1‐Magnetic Resonance Imaging‐Guided •OH Generation DOI
Zhengtao Xu,

Chen Wang,

Zhuangzhuang Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Theranostic probes that integrate diagnosis and treatment together are considered as effective tools for individual therapy. However, the separation of detection components limits precise assessment therapeutic efficacy. Herein, a novel self‐monitoring probe sensitively responds to adenosine triphosphate (ATP) was developed by ultrafine iron oxide nanowires (UIONWs) through an oleyl amine‐assisted way. The UIONWs, with diameter 1.5 nm length 75 nm, surface‐coordinated amine. UIONWs can be decomposed in ATP‐containing solution expose shielded ions. Consequently, it boost peroxidase (POD) activity activate T 1 ‐magnetic resonance imaging (MRI) signal ATP. In addition, rapidly engulfed into cells due high aspect ratio. improved ATP hydrogen peroxide (H 2 O ) within tumor leads higher hydroxyl radicals (OH) generation inhibition.In contrast, normal exhibit lower H levels, reducing cytotoxicity ensuring safety. Since both illumination ‐MRI OH ATP‐controlled, this work raised potential way self‐monitor therapy timely feedback on effects.

Language: Английский

Citations

0