Elaborately Engineered Aggregation‐Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing DOI
Zu‐Sheng Huang, Zhongda Zhang, Yiting Qiu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Developing versatile photosensitizers capable of selectively eliminating pathogens over normal cells is an appealing yet highly challenging task. Herein, a novel strategy by exploiting the cationic and amphiphilic synergistic mechanism introduced to synthesize four aggregation‐induced emission (AIE)‐active antibacterial (PSs) TSPy‐CH 3 , MeO‐TSPy‐Bu MeO‐TSPy‐Va MeO‐TSPy‐CH . The PSs generated both type I II reactive oxygen species (ROS) under white light irradiation. They can quickly stain Staphylococcus aureus ( S. ) in 15 min, but exhibited different Escherichia coli E.coil affinity living cell invasiveness. caused devastating killing methicillin‐resistant (MRSA) at extremely low drug doses significantly inhibited biofilm formation drug‐resistant strains photocytotoxicity inherent dark toxicity. Their concentrations minimal invasiveness toward collectively ensured biosafety. with moderate Clog P value stands out from others virtues most reliable biosafety, broad‐spectrum bactericidal performance, excellent inhibition ability. In vivo studies on bacteria‐infected wounds confirmed that reduced inflammation, promoted angiogenesis, accelerated wound recovery, achieving comparable therapeutic outcomes vancomycin. This work provides enlightenment for designing phototherapy agents overcome key limitations such as unpredictable biosafety risk, inadequate potency, poor anti‐biofilm performance.

Language: Английский

A Sequential Therapeutic Strategy Based on Aptamer/Polymer‐Functionalized PDA/Ag for Precise Acinetobacter Baumannii Imaging and Pneumonia Treatment DOI
Yun Li, Zhen‐Chao Dong, Yingfei Ma

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Acinetobacter baumannii ( A. ) is a leading cause of pneumonia. Conventional antibiotics can increase the risk drug resistance and non‐specifically harm microflora, disrupting their balance. In addition to pathogenic bacteria, lung inflammation also damages tissue. This study develops an aptamer/polymer‐functionalized mesoporous polydopamine/silver nanocomposite (Apt/ODEA‐PDA/Ag‐ICG) specifically target sequentially exhibit antibacterial/antioxidative properties for pneumonia treatment. After synthesizing polyzwitterion (ODEA), polymer/aptamer conjugated with PDA/Ag core, ICG further labeled fabricate nanocomposite. Upon intratracheal instillation, nanocomposites penetrate mucus barrier help polyzwitterions. The precisely targets through specific recognition by aptamer, without affecting other microflora. Moreover, distributed disorderedly within polymer. near core contributes high NIR‐I absorbance good photothermal ability. from acts as fluorescent molecule imaging. Furthermore, efficiently exhibits synergistic antibacterial activity owing acidic environment/heat‐accelerated Ag + release effect. Importantly, alongside release, antioxidant ability PDA scavenges reactive oxygen species alleviates inflammation, thereby accelerating summary, provide alternative approach designing advanced systems.

Language: Английский

Citations

0
Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers DOI Creative Commons
Ran Chen, Yaping Liu, Yanan Jiang

et al.

Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
Synthesis of Alternating Copolymers with Substituents Containing Heteroatoms and the Regulation of Nontraditional Intrinsic Luminescence DOI Open Access

Haitao Leng,

Hongyuan Bai,

Xuefei Wang

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Abstract Compared with other sequence structure polymers, alternating polymers usually have several unique properties, but their properties are more sensitive to changes in structure. By investigating the relationship between and of polymer chains, desired can likely be synthesized. In this study, a series copolymers 1,1‐diphenylethylene (DPE) derivatives styrene derivatives, which exhibit nontraditional intrinsic luminescence (NTIL), synthesized using living anionic polymerization. changing bridge plane DPE substituent groups rigid chain containing derivative large steric hindrance is altered, change observed by altered fluorescence properties. Based on results from experimental tests theoretical simulations, structures higher emission intensities; moreover, balance electronic effects substituents intensities, chains that too cause decrease intensities. Thus, influence NTIL cannot disregarded.

Language: Английский

Citations

0
Elaborately Engineered Aggregation‐Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing DOI
Zu‐Sheng Huang, Zhongda Zhang, Yiting Qiu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Developing versatile photosensitizers capable of selectively eliminating pathogens over normal cells is an appealing yet highly challenging task. Herein, a novel strategy by exploiting the cationic and amphiphilic synergistic mechanism introduced to synthesize four aggregation‐induced emission (AIE)‐active antibacterial (PSs) TSPy‐CH 3 , MeO‐TSPy‐Bu MeO‐TSPy‐Va MeO‐TSPy‐CH . The PSs generated both type I II reactive oxygen species (ROS) under white light irradiation. They can quickly stain Staphylococcus aureus ( S. ) in 15 min, but exhibited different Escherichia coli E.coil affinity living cell invasiveness. caused devastating killing methicillin‐resistant (MRSA) at extremely low drug doses significantly inhibited biofilm formation drug‐resistant strains photocytotoxicity inherent dark toxicity. Their concentrations minimal invasiveness toward collectively ensured biosafety. with moderate Clog P value stands out from others virtues most reliable biosafety, broad‐spectrum bactericidal performance, excellent inhibition ability. In vivo studies on bacteria‐infected wounds confirmed that reduced inflammation, promoted angiogenesis, accelerated wound recovery, achieving comparable therapeutic outcomes vancomycin. This work provides enlightenment for designing phototherapy agents overcome key limitations such as unpredictable biosafety risk, inadequate potency, poor anti‐biofilm performance.

Language: Английский

Citations

0