NIR-II Light-Activated Gold Nanocapsules for CO-Assisted Photothermal–Thermodynamic Synergistic Cancer Therapy DOI

Mengcheng Tang,

Lingfeng Pan,

Hairui Deng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Photothermal therapy (PTT) based on a second near-infrared (NIR-II, 1000-1700 nm) light source holds great promise in the field of tumor treatment. However, hyperthermia-induced heat shock protein (HSP) expression and limited therapeutic efficacy remain major challenges for PTT. Herein, NIR-II laser-responsive nanocapsule PC/AC@GR@HA (abbreviated as P/A@G@H) was designed carbon oxide (CO)-assisted PTT combined with thermodynamic (TDT). P/A@G@H constructed by loading CO storage polymer mPEG(CO) (PC) along free radical initiator 4,4'-azobis(4-cyanovaleric acid) (AC) into gold hollow nanorod (GR), followed surface coating hyaluronic acid (HA). After accumulating tissue through active targeting HA, can quickly cause local hyperthermia upon 1064 nm laser irradiation lead to cell damage GR-mediated Moreover, loaded PC react situ H2O2 produce CO, which inhibits PTT-induced HSP90 expression. This effectively weaken resistance cells enhance effect. Additionally, thermally decomposable initiator, AC turn toxic radicals ablate via TDT under hyperthermia. Our research demonstrates that synergistic strategy combining CO-assistance augment ultimate outcome PTT, integrated could be powerful weapon suppression light.

Language: Английский

Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy DOI
Long He, Yi Li,

Chonghua Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216549 - 216549

Published: Feb. 27, 2025

Language: Английский

Citations

0
Recent advances in nanomaterials for integrated phototherapy and immunotherapy DOI Creative Commons
Zhuqing Sun, Nannan Wang, Yelin Wu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608

Published: March 27, 2025

Language: Английский

Citations

0
NIR-II Light-Activated Gold Nanocapsules for CO-Assisted Photothermal–Thermodynamic Synergistic Cancer Therapy DOI

Mengcheng Tang,

Lingfeng Pan,

Hairui Deng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Photothermal therapy (PTT) based on a second near-infrared (NIR-II, 1000-1700 nm) light source holds great promise in the field of tumor treatment. However, hyperthermia-induced heat shock protein (HSP) expression and limited therapeutic efficacy remain major challenges for PTT. Herein, NIR-II laser-responsive nanocapsule PC/AC@GR@HA (abbreviated as P/A@G@H) was designed carbon oxide (CO)-assisted PTT combined with thermodynamic (TDT). P/A@G@H constructed by loading CO storage polymer mPEG(CO) (PC) along free radical initiator 4,4'-azobis(4-cyanovaleric acid) (AC) into gold hollow nanorod (GR), followed surface coating hyaluronic acid (HA). After accumulating tissue through active targeting HA, can quickly cause local hyperthermia upon 1064 nm laser irradiation lead to cell damage GR-mediated Moreover, loaded PC react situ H2O2 produce CO, which inhibits PTT-induced HSP90 expression. This effectively weaken resistance cells enhance effect. Additionally, thermally decomposable initiator, AC turn toxic radicals ablate via TDT under hyperthermia. Our research demonstrates that synergistic strategy combining CO-assistance augment ultimate outcome PTT, integrated could be powerful weapon suppression light.

Language: Английский

Citations

0