Enhanced Delivery of Photothermal Gelatin Nanoparticle for Redox Balanced Nanocatalytic Tumor Chemotherapy DOI
Jiayi Hu,

Xiaoyu Jia,

Manlin Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Nanocatalytic platforms are promising in cancer therapeutics via combining multiple treatments, which can be leveraged through the metabolic dysfunction progression. However, lack of effective tumor delivery hampers this approach. Here, a gelatin‐based platform is designed that preloaded with gold nanoparticles and photothermal polypyrrole (GNPs@AuNPs‐PPy) an acid‐induced doping enhancement. Benefiting from associated overexpression H 2 O , peroxidase‐like Au induce burst oxidative reactive oxygen species local microenvironment (TME). Subsequent orchestration redox surroundings recruits immune cells, showcasing antineoplastic pathway. Under near infrared light (NIR) irradiation, nanohybrids exhibit dual pH/NIR enhanced drug release within TME, while allowing for multimodal imaging‐guided theranostics. Leveraging modality, GNPs@AuNPs‐PPy delivers quercetin (a natural antitumor mediator) boosting anti‐tumor therapy. The gelatin‐mediated nanomedicine provides alternative combinatorial dynamic treatment.

Language: Английский

Photothermal antimicrobial guar gum hydrogel cross-linked by bioactive small molecule lysine for infected wound healing DOI
Chao Yang, Yan Wang, Zhiyuan Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140328 - 140328

Published: Jan. 1, 2025

Language: Английский

Citations

2
Enhanced Delivery of Photothermal Gelatin Nanoparticle for Redox Balanced Nanocatalytic Tumor Chemotherapy DOI
Jiayi Hu,

Xiaoyu Jia,

Manlin Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Nanocatalytic platforms are promising in cancer therapeutics via combining multiple treatments, which can be leveraged through the metabolic dysfunction progression. However, lack of effective tumor delivery hampers this approach. Here, a gelatin‐based platform is designed that preloaded with gold nanoparticles and photothermal polypyrrole (GNPs@AuNPs‐PPy) an acid‐induced doping enhancement. Benefiting from associated overexpression H 2 O , peroxidase‐like Au induce burst oxidative reactive oxygen species local microenvironment (TME). Subsequent orchestration redox surroundings recruits immune cells, showcasing antineoplastic pathway. Under near infrared light (NIR) irradiation, nanohybrids exhibit dual pH/NIR enhanced drug release within TME, while allowing for multimodal imaging‐guided theranostics. Leveraging modality, GNPs@AuNPs‐PPy delivers quercetin (a natural antitumor mediator) boosting anti‐tumor therapy. The gelatin‐mediated nanomedicine provides alternative combinatorial dynamic treatment.

Language: Английский

Citations

0