Lignin-Mediated Dual Conductive Hydrogels with High Conductivity, Antibacterial Activity and Biocompatibility for Chronic Wound Repair

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 283 - 283

Published: April 11, 2025

In recent years, conductive polymer hydrogels based on polypyrrole (PPy) combined with electrical stimulation (ES) have emerged as a promising approach for chronic wound repair. However, in practical applications, PPy often exhibits limitations such poor water dispersion, weak inherent conductivity and lack of biological functionality. To address these challenges, this study proposes an innovative design hydrogel that employs natural biopolymer, lignin sulfonate (Lgs), both dispersant dopant PPy, while incorporating silver nanoparticles (Ag NPs) to confer the antibacterial properties. The results showed dispersion was significantly improved, high 2.82 ± 0.04 mS/cm through double conduction mechanism Ag NPs. exhibited activity against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus), rate could exceed 90%. vitro tests demonstrated good biocompatibility, adhesion ability (7.97 0.56 kPa) hemostatic ability. Furthermore, vivo animal experiments ES achieved 93.71 2.46% closure within 14 days, which can accelerate healing, promote collagen deposition epithelial tissue regeneration. These findings demonstrate developed serve effective platform ES-assisted

Language: Английский

Smart Self-Powered System Based on Supramolecular Conductive Hydrogel for Assistive Elderly Living

ACS Applied Electronic Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Language: Английский