An emodin-mediated multifunctional nanoplatform with augmented sonodynamic and immunoregulation for osteomyelitis therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 684, P. 122 - 137

Published: Jan. 13, 2025

Language: Английский

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NIR-triggered and Glucose-Powered Hollow mesoporous Mo-based single-atom nanozymes for cascade chemodynamic diabetic infection therapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101557 - 101557

Published: Feb. 5, 2025

Diabetic infections/wounds remain to be a threatening challenge as it seriously leads lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) diabetic infection, but is extremely restricted by the near-neutral pH insufficient H2O2 levels in physiological conditions. Herein, we innovated hollow mesoporous molybdenum nanozyme (HMMo-zyme) featured catalytic activity, photothermal performance drug delivery properties more effective antibacterial therapeutic glucose oxidase (GOx) was encapsulated into HMMo-zyme phase-change material (PCM) form HMMo/GOx@P system, which could controllably disassembled near-infrared ray (NIR) trigger cascade CDT toward bacterial infections. results revealed that release GOx accelerated NIR facilitate continuous conversion (Glu) gluconic acid, accompanied sharply decrease establish low-pH environment notably enhanced HMMo-zyme, subsequently drives generated toxic hydroxyl radicals (·OH) amplified anti-bacterial treatment. As proof concept, this NIR-assisted strategy efficiently inhibit/kill bacteria suppress tissue inflammations, thereby accelerating wound healing processes both vitro vivo infection models. This study provides novel may serve promising alternative antibiotic therapeutics against thus holding treatment manipulating Mo-based SAzymes.

Language: Английский

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Smart self-healing hydrogel wound dressings for diabetic wound treatment

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Feb. 18, 2025

Diabetic wounds are difficult to treat clinically because they heal poorly, often leading severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels capable of continuously dynamically responding changes in the wound environment, feature improved mechanical qualities capacity self-heal damage. We explore latest developments healing this review. First, we systematically summarize obstacles then highlighted significance hydrogels, explaining their stimulus-responsive mechanisms design approaches, along applications addressing these challenges. Finally, discussed unresolved potential avenues future research. anticipate that review will facilitate continued refinement dressings, aiming broader clinical adoption.

Language: Английский

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A brief strategy for the preparation of silk fibroin-copper sulfide-based electrospun nanofibrous membranes with photothermal antimicrobial properties to accelerate the infected wound healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101605 - 101605

Published: Feb. 21, 2025

Language: Английский

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Ternary carbides ZrxAlCx−1: Innovative sol-gel synthesis and their biomedical applications

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114275 - 114275

Published: March 1, 2025

Language: Английский

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Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 00(00)

Published: March 25, 2025

Hypertension represents a highly prevalent chronic condition and stands among the foremost contributors to premature mortality on global scale. Its etiopathogenesis is intricate multifaceted, being shaped by diverse array of elements such as age, genetic predisposition, activation neuroendocrine apparatus. Mounting evidence has shed light significant part that autoimmune responses play in hypertension ensuing damage end organs. Virtually all varieties immune cells, spanning both innate adaptive compartments, exhibit close correlation with progression hypertension. These cells infiltrate kidney vascular mesenchyme, subsequently discharging potent cytokines, reactive oxygen species, metalloproteinases. This cascade events can affect functionality local blood vessels potentially precipitate adverse structural functional alterations crucial organs like heart kidney. In recent times, management end-organ emerged pivotal scientific focus. A multitude researchers are actively engaged probing efficacious intervention regimens, which immunotherapy strategies hold considerable promise anticipation prospective avenue.

Language: Английский

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Photothermal-Boosted chemodynamic nanoplatforms via MXene Supported Pt Single-Atom catalysts for Synergistic MRSA eradication and infected wound Regeneration

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162627 - 162627

Published: April 1, 2025

Language: Английский

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Multifunctional CuTax nanozyme-based chitosan edible coatings for fruit preservation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143204 - 143204

Published: April 1, 2025

Language: Английский

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The immunoglobulin of yolk and cerium oxide-based fibrous poly(L-lactide-co-glycolide)/gelatin dressings enable skin regeneration in an infectious wound model

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101408 - 101408

Published: Dec. 18, 2024

Language: Английский

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