Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches DOI Creative Commons

Yongliang Feng,

Kun Zhang,

Xingrui Gao

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract In the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control action bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and emergence resistance. Over past two decades, field has witnessed great achievements in treating blindness, cancer, diabetes, antibiotic resistance, name but a few. Several challenges remain, however, particular fact most photopharmacological agents trigger their activity by Ultraviolet light, which is damaging normal cells poor tissue permeability. Visible light‐activated are hence highly desirable have captured keen recent research interest. This review highlights strategies for synthesis visible light‐responsive azobenzenes (ABs) applications emerging photopharmacology. Such photoswitchable drugs tremendously extend scope future vivo applications. Furthermore, we identify current discuss rational design switches at higher wavelength. We hope inspire further into photochemistry novel based on ABs or other photoswitches, triggered excitation light “phototherapeutic window” 650–900 nm, ultimately enabling full realization these “smart” clinical practice.

Language: Английский

Engineering in NIR‐responsive photothermal materials and their application in wound healing administration DOI Creative Commons
A. Bassam, Meng-Xuan Du, Yuan Li

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.

Language: Английский

Citations

4
Recent advances in photothermal nanomaterials for ophthalmic applications DOI Creative Commons

Jiayuan Zhuang,

Linhui Jia, Chenghao Li

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2025, Volume and Issue: 16, P. 195 - 215

Published: Feb. 17, 2025

The human eye, with its remarkable resolution of up to 576 million pixels, grants us the ability perceive world astonishing accuracy. Despite this, over 2 billion people globally suffer from visual impairments or blindness, primarily because limitations current ophthalmic treatment technologies. This underscores an urgent need for more advanced therapeutic approaches effectively halt even reverse progression eye diseases. rapid advancement nanotechnology offers promising pathways development novel therapies. Notably, photothermal nanomaterials, particularly well-suited transparent tissues have emerged as a potential game changer. These materials enable precise and controllable therapy by manipulating distribution thermal field. Moreover, they extend beyond conventional boundaries therapy, achieving unparalleled effects through their diverse composite structures demonstrating enormous in promoting retinal drug delivery photoacoustic imaging. paper provides comprehensive summary structure-activity relationship between properties these nanomaterials innovative mechanisms. We review latest research on nanomaterial-based treatments various Additionally, we discuss challenges future perspectives this field, focus enhancing global health.

Language: Английский

Citations

0
Soft Matter Photonics: Interplay of Soft Matter and Light DOI
Lingling Ma,

Yang Wei,

Ning Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

The light-soft matter interaction and its applications form the foundation of Soft Matter Photonics, here termed "Soft Mattonics", positioning it as fertile ground for developing next-generation photonic technologies. Over past few decades, this rapidly evolving field has achieved significant advancements, leading to successful across a wide range disciplines, including optoelectronics, photonics, information technology, material science, robotics, biomedicine, astronomy. In Perspective, we provide an overview Mattonics, highlighting recent developments in light-controlled soft their light manipulating. Additionally, offer insights into future research directions with emphasis on both foundational practical that will drive continued growth innovation field.

Language: Английский

Citations

0
Emerging Frontiers in Spiropyran-Driven Photoresponsive Drug Delivery Systems and Technologies DOI
Ishana Kathuria, Satish Kumar

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112793 - 112793

Published: March 1, 2025

Language: Английский

Citations

0
All‐Visible‐Light Azobenzene Photoswitches for Controlling Dynamic C—N Bonds† DOI
Yongping You, Ye Yang,

Youming Lv

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Comprehensive Summary The visible light‐driven photoswitches are attracting widespread attention, but it is challenging to leverage their phototriggered structural changes regulate dynamic bonds, assemblies, and materials. Herein, we incorporated reversible covalent sites of aldehyde ring‐chain tautomers into all‐visible‐light azobenzenes toward a versatile platform for light‐controlled formation/exchange C—N bonds from secondary amines. movement equilibrium was attained via manipulating intramolecular multiple hydrogen bonding E / Z configurational isomers. Such regulation further enabled photocontrolled kinetics the formation exchange reactions cyclic hemiaminal ethers amines exhibiting kinetic rate reversal varied capability isomers in engaging azo attached carboxylate with ammonium salt accounts difference. Moreover, photoswitching performance different solutions readily regulated by reactivity control light associated mechanistic foundation add collection photoswitchable chemistry would lay subsequent biological material applications.

Language: Английский

Citations

0
Study on the Photoinduced Isomerization Mechanism of Hydrazone Derivatives Molecular Switch DOI Creative Commons
Xiaojuan Pang,

Kaiyue Zhao,

Chenghao Yang

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Improving quantum yield is an important characteristic for enhancing the operational efficiency of light-driven molecular motors. Building upon Cigan et al.'s pioneering work on CH3 substitution H (RSC Adv., 2015, 5, 62449), we have developed a structural modification strategy hydrazone-based switches through replacement single oxygen atom with two hydrogen atoms, resulting in remarkable enhancement yield. We systematically investigate photoinduced isomerization mechanism hydrazone derivatives switch using Tully's surface hopping method semiempirical OM2/MRCI level. The results show that calculated E-to-Z photoisomerization this rotary motor approximately (55 ± 3)% (16.01% original (Pang, X.-J.; Zhao, K.-Y.; He, H.-Y.; Zhang, N.-B.; Jiang, C.-W. Photoinduced isatin N2-diphenylhydrazones switch. Acta Phys. Sin. 2024, 73 (17).) average lifetime excited state 122 fs. Additionally, calculate time-dependent fluorescence emission spectra and observe redshift wavelength accompanied by quenching, which shows blue shift compared to N2-diphenylhydrazone spectrum. Furthermore, propose may not "dark state".

Language: Английский

Citations

0
Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches DOI Creative Commons

Yongliang Feng,

Kun Zhang,

Xingrui Gao

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract In the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control action bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and emergence resistance. Over past two decades, field has witnessed great achievements in treating blindness, cancer, diabetes, antibiotic resistance, name but a few. Several challenges remain, however, particular fact most photopharmacological agents trigger their activity by Ultraviolet light, which is damaging normal cells poor tissue permeability. Visible light‐activated are hence highly desirable have captured keen recent research interest. This review highlights strategies for synthesis visible light‐responsive azobenzenes (ABs) applications emerging photopharmacology. Such photoswitchable drugs tremendously extend scope future vivo applications. Furthermore, we identify current discuss rational design switches at higher wavelength. We hope inspire further into photochemistry novel based on ABs or other photoswitches, triggered excitation light “phototherapeutic window” 650–900 nm, ultimately enabling full realization these “smart” clinical practice.

Language: Английский

Citations

0