Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm DOI Creative Commons

Keng Ye,

Kevin Lin, Chengkun Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 27, 2025

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising new opportunities for prevention treatment AKI mitigating oxidative stress. Here, we construct an ultrasmall platinum single-atom enzyme (Pt/SAE) multiple antioxidant activities to protect against acute ischemia-reperfusion (I/R) injury. Pt/SAE not only mimics superoxide dismutase catalase convert anion into water oxygen, but also exhibits impressive hydroxyl radical scavenging capacity, thereby reducing pro-inflammatory macrophage levels preventing inflammation. Furthermore, reduces accumulation Z-form DNA, which excessively accumulates following I/R damage, thus decreasing its interaction Z-DNA binding protein 1, consequently progression PANoptosis Additionally, downregulation induced suppresses lipid peroxidation, return ferroptosis I/R. Both vitro vivo experiments confirm that effectively mitigates inflammatory cell infiltration promotes shift polarization from M1-like M2-like subtype. This study information development novel SAEs as viable method AKI.

Language: Английский

Nanomedicines as disruptors or inhibitors of biofilms: Opportunities in addressing antimicrobial resistance DOI Creative Commons
Jiaming Lan, Jingyu Zou, He Xin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113589 - 113589

Published: March 1, 2025

The problem of antimicrobial resistance (AMR) has caused global concern due to its great threat human health. Evidences are emerging for a critical role biofilms, one the natural protective mechanisms developed by bacteria during growth, in resisting commonly used clinical antibiotics. Advances nanomedicines with tunable physicochemical properties and unique anti-biofilm provide opportunities solving AMR risks more effectively. In this review, we summarize five "A" stages (adhesion, amplification, alienation, aging allocation) biofilm formation through which they protect internal bacteria. Aimed at characteristics emphasize design "THAT" principles (targeting, hacking, adhering transport) their interactions biofilms Furthermore, recent progresses multimodal antibacterial nanomedicines, including disruption bactericidal activity, types currently available antibiofilm contained organic inorganic outlined highlighted potential applications development preclinical research. Last but not least, offer perspective effectiveness designed address challenges associated translation.

Language: Английский

Citations

1
Bimetallic Metal–Organic Framework Microneedle Array for Wound Healing through Targeted Reactive Oxygen Species Generation and Electron Transfer Disruption DOI

Sirong Sun,

Xiangyu Liu, Xiangdan Meng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

The development of reactive oxygen species (ROS)-based antibacterial strategies that overcome ROS's ultrashort diffusion distance and disrupt bacterial electron transfer represents a promising yet underexplored avenue for nonantibiotic therapies. In this study, we introduce an iron-copper bimetallic metal-organic framework (MOF) with peroxidase (POD)-like enzymatic activity engineered to integrate dual functionalities: bactericidal recognition disruption synergistically enhance efficacy. Mechanistic investigations reveal boronic-acid-cis-diol interactions enable the MOF selectively bind membranes, where it generates localized ROS, effectively killing bacteria. Concurrently, alignment energy levels redox potential facilitates efficient from membrane MOFs, disrupting integrity inhibiting critical processes such as transport ATP synthesis. When incorporated into biodegradable microneedle patches, penetrates biofilms wound exudates, delivering potent effects directly infection sites while simultaneously promoting tissue repair. This strategic combination targeting, disruption, microneedle-mediated delivery highlights approach advance

Language: Английский

Citations

0
Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm DOI Creative Commons

Keng Ye,

Kevin Lin, Chengkun Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 27, 2025

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising new opportunities for prevention treatment AKI mitigating oxidative stress. Here, we construct an ultrasmall platinum single-atom enzyme (Pt/SAE) multiple antioxidant activities to protect against acute ischemia-reperfusion (I/R) injury. Pt/SAE not only mimics superoxide dismutase catalase convert anion into water oxygen, but also exhibits impressive hydroxyl radical scavenging capacity, thereby reducing pro-inflammatory macrophage levels preventing inflammation. Furthermore, reduces accumulation Z-form DNA, which excessively accumulates following I/R damage, thus decreasing its interaction Z-DNA binding protein 1, consequently progression PANoptosis Additionally, downregulation induced suppresses lipid peroxidation, return ferroptosis I/R. Both vitro vivo experiments confirm that effectively mitigates inflammatory cell infiltration promotes shift polarization from M1-like M2-like subtype. This study information development novel SAEs as viable method AKI.

Language: Английский

Citations

0