The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy DOI Creative Commons

Meng-Jie Zhang,

Yan Wen, Zhi‐Jun Sun

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 13, 2025

Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate. Tertiary lymphoid structure (TLS) plays crucial role antitumor immunity and associated with good prognosis. Metabolic reprogramming, as hallmark tumor microenvironment, can influence promote formation follicular helper T cells germinal centers. many current studies focus on correlation between metabolism TLS factors, there insufficient direct evidence to suggest that drives formation. This review provided comprehensive summary relationship formation, highlighting glucose metabolism, lipid amino acid vitamin metabolism. In future, an in-depth exploration how affects cell interactions microorganisms will significantly advance our understanding metabolism-enhanced immunity.

Language: Английский

A stimuli-responsive immunostimulant to activate chemo-immunotherapeutic effects by inducing DNA damage and STING activation DOI

Shuiying Zhang,

Hangyu Zhou, Yixin Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 688, P. 664 - 676

Published: Feb. 26, 2025

Language: Английский

Citations

0
The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy DOI Creative Commons

Meng-Jie Zhang,

Yan Wen, Zhi‐Jun Sun

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 13, 2025

Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate. Tertiary lymphoid structure (TLS) plays crucial role antitumor immunity and associated with good prognosis. Metabolic reprogramming, as hallmark tumor microenvironment, can influence promote formation follicular helper T cells germinal centers. many current studies focus on correlation between metabolism TLS factors, there insufficient direct evidence to suggest that drives formation. This review provided comprehensive summary relationship formation, highlighting glucose metabolism, lipid amino acid vitamin metabolism. In future, an in-depth exploration how affects cell interactions microorganisms will significantly advance our understanding metabolism-enhanced immunity.

Language: Английский

Citations

0