Self‐Propelled Bacteria‐Mediated In Situ Biosynthesis of MnS Nanoparticles for Remodeling Tumor Microenvironment to Amplify cGAS‐STING Pathway for Antitumor Immunity DOI
Mengna Dong, Charlie Changli Xue, Xinhui Yang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Abstract cGAS‐STING pathway, an important innate immune signaling has attracted extensive attention in anti‐tumor immunotherapy research. However, the limited delivery ratio of STING agonists and lactate‐induced lactylation present significant challenges advancing antitumor response. Herein, natural anaerobic sulfate‐reducing bacteria (SRB) are utilized as a biofactory to situ biosynthesize MnS nanoparticles (MnS@SRB) for amplifying MnS‐activated responses through continuous lactate depletion by SRB. After intravenous injection, MnS@SRB can actively migrate tumor tissues via SRB‐mediated hypoxia targeting, further continually release H 2 S Mn 2+ acidic microenvironment. stimulates mitochondrial dysfunction induces DNA leakage, which is then recognized cGAS activate pathway. augments STING‐mediated secretion type I interferons inflammatory factors. Importantly, effectively metabolize tumors, thereby alleviating response regulating macrophage phenotype M1‐type, reducing tumor‐infiltrating regulatory T cells increasing CD8 + level, enhancing both adaptive immunosurveillance. As result, inhibite tumors growth metastasis. Therefore, MnS@SRB‐based system enables efficient activator immunosuppressive microenvironment remodeling, opening new avenue synergistically enhanced activation.

Language: Английский

A multifunctional nanoplatform based on chlorin e6 for fluorescence imaging-guided sonodynamic and chemodynamic cancer therapy DOI
Qi Xu,

Fang He,

Zhimin Mo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114718 - 114718

Published: April 21, 2025

Language: Английский

Citations

0
Integrative gas-based therapeutics for cancer treatment: Recent advances and multi-therapy innovations DOI

Jiaqing Zhang,

Xiang Cao,

Huiyun Wen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216746 - 216746

Published: May 2, 2025

Language: Английский

Citations

0
Self‐Propelled Bacteria‐Mediated In Situ Biosynthesis of MnS Nanoparticles for Remodeling Tumor Microenvironment to Amplify cGAS‐STING Pathway for Antitumor Immunity DOI
Mengna Dong, Charlie Changli Xue, Xinhui Yang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Abstract cGAS‐STING pathway, an important innate immune signaling has attracted extensive attention in anti‐tumor immunotherapy research. However, the limited delivery ratio of STING agonists and lactate‐induced lactylation present significant challenges advancing antitumor response. Herein, natural anaerobic sulfate‐reducing bacteria (SRB) are utilized as a biofactory to situ biosynthesize MnS nanoparticles (MnS@SRB) for amplifying MnS‐activated responses through continuous lactate depletion by SRB. After intravenous injection, MnS@SRB can actively migrate tumor tissues via SRB‐mediated hypoxia targeting, further continually release H 2 S Mn 2+ acidic microenvironment. stimulates mitochondrial dysfunction induces DNA leakage, which is then recognized cGAS activate pathway. augments STING‐mediated secretion type I interferons inflammatory factors. Importantly, effectively metabolize tumors, thereby alleviating response regulating macrophage phenotype M1‐type, reducing tumor‐infiltrating regulatory T cells increasing CD8 + level, enhancing both adaptive immunosurveillance. As result, inhibite tumors growth metastasis. Therefore, MnS@SRB‐based system enables efficient activator immunosuppressive microenvironment remodeling, opening new avenue synergistically enhanced activation.

Language: Английский

Citations

0