Fe3O4@Bi2S3 Nanoparticles Mediated MRI-Guided Precision Radiosensitization for Orthotopic Glioblastoma via External Magnetism DOI
Xiaowei Song, Liang Xiao, Lingling Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Radioresistance in tumors and the excess damage normal tissues during radiotherapy (RT) restrict clinical application of glioblastoma RT. Image-guided radiosensitization is hopefully adopted to achieve precision Nevertheless, therapeutic effect radiosensitizers unsatisfactory due limitations blood–brain barrier poor tumor targeting. Herein, Fe3O4@Bi2S3 nanoparticles coated with a cell membrane (denoted as FBM) have been designed sensitize FBM accumulates precisely within via external magnetism homologous adhesion capability. Afterward, releases high-Z atoms (Bismuth) ionizing radiation micro acidic environments that interact generate high densities secondary radiation, which leads enhanced dose deposits. Simultaneously, generates reactive oxygen species, lipid peroxidation Fe2+, depletes glutathione, downregulates glutathione peroxidase 4 activate ferroptosis. Notably, growth inhibition rate FBM-mediated RT increases 75.49% orthotopic model. Besides, magnetic resonance imaging performance shows potential diagnosis therapy surveillance, thereby reducing adjacent realizing MRI-guided Hence, novel multifunctional nanoplatform offers for image-guided induced by activating ferroptosis, thus presenting an efficient radiotherapeutic approach glioblastoma.

Language: Английский

Fe3O4@Bi2S3 Nanoparticles Mediated MRI-Guided Precision Radiosensitization for Orthotopic Glioblastoma via External Magnetism DOI
Xiaowei Song, Liang Xiao, Lingling Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Radioresistance in tumors and the excess damage normal tissues during radiotherapy (RT) restrict clinical application of glioblastoma RT. Image-guided radiosensitization is hopefully adopted to achieve precision Nevertheless, therapeutic effect radiosensitizers unsatisfactory due limitations blood–brain barrier poor tumor targeting. Herein, Fe3O4@Bi2S3 nanoparticles coated with a cell membrane (denoted as FBM) have been designed sensitize FBM accumulates precisely within via external magnetism homologous adhesion capability. Afterward, releases high-Z atoms (Bismuth) ionizing radiation micro acidic environments that interact generate high densities secondary radiation, which leads enhanced dose deposits. Simultaneously, generates reactive oxygen species, lipid peroxidation Fe2+, depletes glutathione, downregulates glutathione peroxidase 4 activate ferroptosis. Notably, growth inhibition rate FBM-mediated RT increases 75.49% orthotopic model. Besides, magnetic resonance imaging performance shows potential diagnosis therapy surveillance, thereby reducing adjacent realizing MRI-guided Hence, novel multifunctional nanoplatform offers for image-guided induced by activating ferroptosis, thus presenting an efficient radiotherapeutic approach glioblastoma.

Language: Английский

Citations

0