Mechanically‐Compliant Magnetoelectric Sutures for Wound Management

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 24, 2025

Abstract Sutures are the standard approach for wound closure and surgical incisions, but their clinical utility is constrained by inherent mechanical mismatch absence of multifunctional capabilities. While electrical stimulation has emerged as a promising nonpharmacological strategy accelerated healing, achieving seamless integration on‐demand, untethered with suture systems persists critical challenge. Here, magnetoelectric developed incorporating core‐shell nanoparticles within piezoelectric P(VDF‐TrFE) matrix. Upon external magnetic field exposure, magneto‐mechano‐electric cascade synergistically generated programmable output, thereby enabling spatiotemporally controlled at site. The ME engineered polyzwitterionic hydrogel skin, imparting them improved compliance, biocompatibility, reduced foreign body response, friction‐minimized removal. In rat incisional model, daily induction achieved significantly faster healing reducing recovery time from ten days to just five days. This work establishes paradigm intelligent systems, offering theranostic platform that synergizes mechanoadaptive properties electrically augmented tissue repair next‐generation management.

Language: Английский

Hydrogel-Based Biointerfaces: Recent Advances, Challenges, and Future Directions in Human–Machine Integration

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 232 - 232

Published: March 23, 2025

Human–machine interfacing (HMI) has emerged as a critical technology in healthcare, robotics, and wearable electronics, with hydrogels offering unique advantages multifunctional materials that seamlessly connect biological systems electronic devices. This review provides detailed examination of recent advancements hydrogel design, focusing on their properties potential applications HMI. We explore the key characteristics such biocompatibility, mechanical flexibility, responsiveness, which are essential for effective long-term integration tissues. Additionally, we highlight innovations conductive hydrogels, hybrid composite materials, fabrication techniques 3D/4D printing, allow customization to meet demands specific HMI applications. Further, discuss diverse classes polymers contribute conductivity, including conducting, natural, synthetic, polymers, emphasizing role enhancing electrical performance adaptability. In addition material examine regulatory landscape governing hydrogel-based biointerfaces applications, addressing considerations clinical translation commercialization. An analysis patent insights into emerging trends shaping future technologies human–machine interactions. The also covers range neural interfaces, soft haptic systems, where play transformative Thereafter, addresses challenges face issues related stability, scalability, while perspectives continued evolution technologies.

Language: Английский

Conductive Hydrogels with Topographical Geometry and Mechanical Robustness for Enhanced Peripheral Nerve Regeneration

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Nerve guidance conduits (NGCs) emerge as a promising solution for nerve regeneration; however, conventional NGCs fail to fulfill the requirements peripheral regeneration, which are subjected periodical yet vigorous stretching, bending, and compression. Here, we developed fatigue-resistant conductive hydrogel-based NGC by integrating topographical geometry, enhanced electroactivity, superior fatigue resistance within one unit. The hydrogel, consisting of PVA matrix with PEDOT:PSS filler, features alignment that promotes axonal growth achieves threshold over 500 J/m2, making it well-suited sciatic repairing. Phase segregation PEDOT chains enhances its electrical conductivity (>500 S/m) mitigates interfacial impedance mismatch, allowing high-efficiency bioelectrical signal transmission. In vivo studies on rat injury model corroborate accelerated regeneration through improved motor function recovery efficient electrophysiological These findings establish our synergy topographical, mechanical, engineering.

Language: Английский