Biodegradable Piezoelectric Janus Membrane Enabling Dual Antibacterial and Osteogenic Functions for Periodontitis Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Guided tissue regeneration (GTR) using barrier membranes is a common clinical approach for treating periodontitis-induced alveolar bone loss. However, conventional GTR lack antibacterial and osteoinductive properties, limiting their effectiveness. Piezoelectric materials, which generate electrical outputs under chewing forces, offer bone-regenerative potential due to oppositely charged surfaces. Inspired by this, piezoelectric Janus membrane was developed dual-function therapy. Biodegradable poly(l-lactide) (PLLA) PLLA/gelatin were electrospun, annealed, polarized create the A-P(+)/PG(-) membrane. Notably, in this membrane, outer surface of PLLA side (A-P(+)) carries positive charges positioned toward gingival kill bacteria via charge interactions; inner PG (PG(-)) holds negative faces defect, promoting growth through immunomodulation enhanced mineralization. In mouse model periodontitis, demonstrated dual functionality, effectively reducing inflammation, inhibiting resorption. The mineral density reached 1637 ± 37 mg/cm3 at 8 weeks after surgery, superior commercial collagen lacking properties. Overall, study introduces an innovative approach, leveraging biodegradable construct versatile with osteogenic activity periodontitis treatment.

Language: Английский

Photo-synthesis of sensing silk fibroin fibers with double-network structures

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142934 - 142934

Published: April 1, 2025

Language: Английский