Centrifugal Spinning-Derived Biomimetic Aerogel for Rapid Hemostasis with Minimal Blood Loss

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

For emergency treatment, especially in situations where rapid and effective hemostasis is required beyond the natural clotting mechanisms, advanced materials designed to reduce bleeding time minimize blood loss have become an urgent need. Herein, a root hair-inspired aerogel developed, which characterized by 99.99% interconnected pore structure three-dimensional network constructed blocked aqueous isocyanates cross-linked grooved cellulose acetate wrinkled thermoplastic polyurethane fibers via centrifugal spinning. The exhibits enhanced water absorption minimal adsorption through coagulation cascade activation. In vivo studies using rat tail, hepatic, renal injury models demonstrate substantial reduction (∼94%) (∼78%) compared commercial hemostats. developed offers promising solution for hemorrhage control.

Language: Английский

Bioactive Polyurethane Shape Memory Polymer Foam Dressings with Enhanced Blood and Cell Interactions for Improved Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Polyurethane (PUr) shape memory polymer (SMP) foams have demonstrated excellent bleeding control in traumatic wounds. Unlike the current clinically available treatment options, PUr SMP can address noncompressible bleeds, are safe for prolonged use, and highly tunable, offering broad functionalities like biodegradation antimicrobial properties. Despite their hemostatic efficacy, PUrs entirely synthetic, which limits long-term healing capacity if left a wound to degrade. This work employed methods facile incorporation of bioactive collagen gelatin into postfabrication enhance clotting efficacy drive cell interactions. The procoagulant nature increased accomplished by foams. Additionally, promoted attachment, spreading, proliferation on foam pores, could facilitate tissue migration scaffold promote repair. Overall, dressing significantly improve outcomes.

Language: Английский

Osteoinductive gelatin-based porous nanocomposite hydrogel for enhanced hemorrhagic bone defect repair

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 316, P. 144658 - 144658

Published: May 26, 2025

Language: Английский