Chemodynamic Therapy Enhanced 131I‐Radiotherapy for Efficient Inhibition on Cancer Growth and Metastasis DOI

Caiting Deng,

Jingjing Zhang, Yuchen Yang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Iodine‐131 ( 131 I), a cornerstone of thyroid cancer therapy, suffers from limited efficacy in other cancers due to poor tumor accumulation and hypoxia‐driven radiotherapy resistance. To overcome these challenges, I‐M@HI, theranostic nanoparticle was engineered that synergizes with chemodynamic therapy (CDT). This platform integrated Mn(III) porphyrin indocyanine green self‐assembled on albumin, enabling dual‐mode fluorescence/MRI‐guided imaging, tumor/sentinel lymph node‐targeted accumulation, hypoxia modulation. The catalyzes intratumoral hydrogen peroxide into cytotoxic hydroxyl radicals for CDT while alleviating amplify I radiotherapy. In subcutaneous tumors, I‐M@HI achieved >85% inhibition by inducing immunogenic cell death, marked calreticulin exposure high mobility group box 1 release, triggered systemic anti‐tumor immunity. Strikingly, breast metastasis model, selectively eradicated sentinel node metastases, reducing lung metastatic nodules >90%, representing critical advancement preventing spread. work pioneers multifunctional nanoplatform not only enhances but also redefines precision inhibition, offering transformative strategy advanced therapy.

Language: Английский

Nanomaterial-Based Molecular Imaging in Cancer: Advances in Simulation and AI Integration DOI Creative Commons
James C. L. Chow

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 444 - 444

Published: March 20, 2025

Nanomaterials represent an innovation in cancer imaging by offering enhanced contrast, improved targeting capabilities, and multifunctional modalities. Recent advancements material engineering have enabled the development of nanoparticles tailored for various techniques, including magnetic resonance (MRI), computed tomography (CT), positron emission (PET), ultrasound (US). These nanoscale agents improve sensitivity specificity, enabling early detection precise tumor characterization. Monte Carlo (MC) simulations play a pivotal role optimizing nanomaterial-based modeling their interactions with biological tissues, predicting contrast enhancement, refining dosimetry radiation-based techniques. computational methods provide valuable insights into nanoparticle behavior, aiding design more effective agents. Moreover, artificial intelligence (AI) machine learning (ML) approaches are transforming enhancing image reconstruction, automating segmentation, improving diagnostic accuracy. AI-driven models can also optimize MC-based accelerating data analysis through predictive modeling. This review explores latest imaging, highlighting synergy between nanotechnology, MC simulations, innovations. By integrating these interdisciplinary approaches, future technologies achieve unprecedented precision, paving way diagnostics personalized treatment strategies.

Language: Английский

Citations

2
Micro-Nano Convergence-Driven Radiotheranostic Revolution in Hepatocellular Carcinoma DOI
Yisheng Peng,

Hui Liu,

Mengmeng Miao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

Radiotherapy, as an important means of treating hepatocellular carcinoma (HCC), has shown unique therapeutic advantages, especially in patients who are unable to undergo surgery or transplantation. It mainly includes external radiotherapy, transarterial radioembolization and intratumoral radioactive particle implantation. However, under the influence factors such hypoxic characteristics liver tumor microenvironment radioresistance cells, effect radiotherapy may be unstable cause side effects, affecting quality life patients. In recent years, with development nanotechnology, drug delivery systems based on micro-nanomaterials have provided new solutions for improving HCC. Despite this, application micro-nano treatment HCC still faces some challenges, including vivo safety metabolism materials. This article reviews latest progress materials HCC, their radiosensitization clinical translation potential. systematically analyzes role internal sensitization radioimmunotherapy explores advantages

Language: Английский

Citations

0
Chemodynamic Therapy Enhanced 131I‐Radiotherapy for Efficient Inhibition on Cancer Growth and Metastasis DOI

Caiting Deng,

Jingjing Zhang, Yuchen Yang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Iodine‐131 ( 131 I), a cornerstone of thyroid cancer therapy, suffers from limited efficacy in other cancers due to poor tumor accumulation and hypoxia‐driven radiotherapy resistance. To overcome these challenges, I‐M@HI, theranostic nanoparticle was engineered that synergizes with chemodynamic therapy (CDT). This platform integrated Mn(III) porphyrin indocyanine green self‐assembled on albumin, enabling dual‐mode fluorescence/MRI‐guided imaging, tumor/sentinel lymph node‐targeted accumulation, hypoxia modulation. The catalyzes intratumoral hydrogen peroxide into cytotoxic hydroxyl radicals for CDT while alleviating amplify I radiotherapy. In subcutaneous tumors, I‐M@HI achieved >85% inhibition by inducing immunogenic cell death, marked calreticulin exposure high mobility group box 1 release, triggered systemic anti‐tumor immunity. Strikingly, breast metastasis model, selectively eradicated sentinel node metastases, reducing lung metastatic nodules >90%, representing critical advancement preventing spread. work pioneers multifunctional nanoplatform not only enhances but also redefines precision inhibition, offering transformative strategy advanced therapy.

Language: Английский

Citations

0