Frontiers in Bioengineering and Biotechnology,
Journal Year:
2020,
Volume and Issue:
8
Published: May 5, 2020
Intelligent
drug
delivery
systems
based
on
nanotechnology
have
been
widely
developed
and
investigated
in
the
field
of
nanomedicine
since
they
were
able
to
maximize
therapeutic
efficacy
minimize
undesirable
adverse
effects.
Among
a
variety
organic
or
inorganic
nanomaterials
available
fabricate
for
cancer
therapy
diagnosis,
poly(D,L-lactic-co-glycolic
acid)
(PLGA)
has
extensively
employed
due
its
biocompatibility
biodegradability.
In
this
paper,
we
review
recent
status
research
application
PLGA-based
(DDSs)
remotely
triggered
tumor
diagnosis.
We
discuss
targeting
strategies
which
provide
DDSs
with
passive,
active
magnetic
tumor-targeting
abilities.
And
employment
further
discussed,
including
ultrasound-triggered,
photo-triggered,
field-triggered,
radiofrequency-triggered
therapy.
Ultrasound-triggered
involves
high
intensity
focused
ultrasound
(HIFU)
treatment,
ultrasound-triggered
chemotherapeutic
release,
ultrasound-enhanced
efficiency
gene
transfection.
Photo-triggered
photodynamic
(PDT),
photothermal
(PTT),
photo-triggered
release.
Additionally,
also
endows
imaging
properties.
Numerous
studies
cited
our
demonstrate
great
potential
as
effective
theranostic
agent
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(3), P. 454 - 454
Published: March 17, 2023
In
recent
years,
biodegradable
polymers
have
gained
the
attention
of
many
researchers
for
their
promising
applications,
especially
in
drug
delivery,
due
to
good
biocompatibility
and
designable
degradation
time.
Poly
(lactic-co-glycolic
acid)
(PLGA)
is
a
functional
polymer
made
from
polymerization
lactic
acid
(LA)
glycolic
(GA)
widely
used
pharmaceuticals
medical
engineering
materials
because
its
biocompatibility,
non-toxicity,
plasticity.
The
aim
this
review
illustrate
progress
research
on
PLGA
biomedical
as
well
shortcomings,
provide
some
assistance
future
development.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(28)
Published: Aug. 24, 2023
The
treatment
of
bone
defects
remains
a
significant
challenge
to
be
solved
clinically.
Immunomodulatory
properties
orthopedic
biomaterials
have
significance
in
regulating
osteoimmune
microenvironment
for
osteogenesis.
A
lactic
acid-co-glycolic
acid
(PLGA)
scaffold
incorporates
black
phosphorus
(BP)
fabricated
by
3D
printing
technology
investigate
the
effect
BP
on
osteoimmunomodulation
and
osteogenesis
site.
PLGA/BP
exhibits
suitable
biocompatibility,
biodegradability,
mechanical
as
an
excellent
support
new
formation.
studies'
result
also
demonstrate
that
scaffolds
are
able
recruit
stimulate
macrophages
M2
polarization,
inhibit
inflammation,
promote
human
marrow
mesenchymal
stem
cells
(hBMSCs)
proliferation
differentiation,
which
turn
promotes
regeneration
distal
femoral
defect
region
steroid-associated
osteonecrosis
(SAON)
rat
model.
Moreover,
it
is
screened
demonstrated
can
osteogenic
differentiation
transcriptomic
analysis,
mineralization
activating
PI3K-AKT
signaling
pathway
hBMSC
cells.
In
this
study,
shown
innovative
extremely
effective
stimulating
macrophage
polarization
strategy
development
used
repair
offered.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(18), P. 2606 - 2606
Published: Sept. 14, 2024
Poly(lactic-co-glycolic
acid)
(PLGA)
is
a
widely
used
biodegradable
and
biocompatible
copolymer
in
drug
delivery
systems
(DDSs).
In
this
article,
we
highlight
the
critical
physicochemical
properties
of
PLGA,
including
its
molecular
weight,
intrinsic
viscosity,
monomer
ratio,
blockiness,
end
caps,
that
significantly
influence
release
profiles
degradation
times.
This
review
also
covers
extensive
literature
on
application
PLGA
delivering
small-molecule
drugs,
proteins,
peptides,
antibiotics,
antiviral
drugs.
Furthermore,
discuss
role
PLGA-based
DDSs
treating
various
diseases,
cancer,
neurological
disorders,
pain,
inflammation.
The
incorporation
drugs
into
nanoparticles
microspheres
has
been
shown
to
enhance
their
therapeutic
efficacy,
reduce
toxicity,
improve
patient
compliance.
Overall,
holds
great
promise
for
advancement
treatment
management
multiple
chronic
conditions.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 26, 2025
Abstract
The
central
nervous
system
(CNS)
diseases
are
major
contributors
to
death
and
disability
worldwide.
However,
the
blood–brain
barrier
(BBB)
often
prevents
drugs
intended
for
CNS
from
effectively
crossing
into
brain
parenchyma
deliver
their
therapeutic
effects.
is
a
semi-permeable
with
high
selectivity.
BBB
primarily
manages
transport
of
substances
between
blood
CNS.
To
enhance
drug
delivery
disease
treatment,
various
brain-based
strategies
overcoming
have
been
developed.
Among
them,
nanoparticles
(NPs)
emphasized
due
multiple
excellent
properties.
This
review
starts
an
overview
BBB’s
anatomical
structure
physiological
roles,
then
explores
mechanisms,
both
endogenous
exogenous,
that
facilitate
NP
passage
across
BBB.
text
also
delves
how
nanoparticles'
shape,
charge,
size,
surface
ligands
affect
ability
cross
offers
different
nanoparticle
classifications.
concludes
examination
current
challenges
in
utilizing
nanomaterials
discusses
corresponding
directions
solutions.
aims
propose
innovative
diagnostic
approaches
design
more
effective
Graphical
abstract
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 22, 2025
Abstract
An
integrated
strategy
that
combines
innovative
electrospinning
technique
with
traditional
hot‐stretching
post‐treatment
is
designed
and
implemented
to
generate
high‐molecular‐weight
poly(l‐lactic‐acid)
(hmwPLLA,
Mw
=
2
80
000
Da)
electrospun
nanofiber‐constructed
yarns
(ENCYs).
The
internal
fiber
diameter
within
the
hmwPLLA
ENCYs
found
increase
gradually
of
solution
concentration.
ENCY
generated
from
a
concentration
10%
(w
v
−1
)
demonstrated
uniform
morphology
an
average
737.7
±
72.2
nm
yarn
454.9
3.5
µm.
Compared
unstretched
ENCY,
increasing
temperature
can
significantly
enhance
orientation
crystallinity.
Moreover,
mechanical
properties
stretched
are
obviously
enhanced
compared
control.
crystallinity
also
be
improved
hot
stretching
rate,
further
resulting
in
obvious
breaking
strength
Young's
modulus.
Importantly,
braided
textiles
made
exhibited
great
biocompatibility
by
effectively
guiding
cell
alignment
supporting
adhesion
proliferation.
In
summary,
high
performance
show
potential
for
future
design
development
advanced
biomedical
textiles.
