ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(2), P. 2038 - 2067
Published: Jan. 23, 2021
Innovative
multifunctional
nanomaterials
have
attracted
tremendous
interest
in
current
research
by
facilitating
simultaneous
cancer
imaging
and
therapy.
Among
them,
antimony
(Sb)-
bismuth
(Bi)-based
nanoparticles
are
important
species
with
multifunction
to
boost
theranostic
efficacy.
Despite
the
rapid
development,
extensive
previous
work
treated
Sb-
Bi-based
as
mutually
independent
species,
therefore
a
thorough
understanding
of
their
relationship
theranostics
was
lacking.
We
propose
here
that
identical
chemical
nature
Sb
Bi,
being
semimetals,
provides
derived
inherent
for
near-infrared
laser-driven
and/or
X-ray-based
therapy
well
some
other
imparted
functions.
An
overview
recent
progress
on
is
provided
highlight
between
multifunction.
The
this
way
might
shed
light
further
design
smart
theranostics.
Journal of Materials Chemistry B,
Journal Year:
2019,
Volume and Issue:
8(3), P. 368 - 379
Published: Nov. 13, 2019
Nowadays,
groundbreaking
strategies
are
urgently
needed
to
address
drug
resistance,
osteolysis,
bone
defects
and
other
predicaments
impeding
the
therapeutic
efficacy
of
osteosarcoma.
Among
them,
photothermal
therapy
(PTT),
using
systematically
administrated
nanoagents,
exhibits
attractive
efficacy,
yet
is
powerless
in
defect
regeneration.
Herein,
a
novel
multifunctional
beta-tricalcium
phosphate
(β-Ca3(PO4)2,
β-TCP)
bioceramic
platform-coated
with
carbon
aerogel
(CA),
which
was
initially
developed
for
tumor
therapy,
fabricated.
On
account
desirable
capabilities
CA,
sufficient
hyperthermia
generated
under
irradiation
an
808
nm
laser
achieve
thorough
ablation
osteosarcoma
tumors.
Furthermore,
CA-coated
surfaces
provide
extra
roughness
higher
specific
surface
area,
promoted
protein
recruitment
ability
osteogenesis
via
fibronectin
(FN)-mediated
signaling
pathway.
The
capability
β-TCP-C
suggests
approach
treatment
provides
provoking
inspiration
prospective
bio-application
CA.
Materials,
Journal Year:
2020,
Volume and Issue:
13(17), P. 3795 - 3795
Published: Aug. 27, 2020
A
biomedical
contrast
agent
serves
to
enhance
the
visualisation
of
a
specific
(potentially
targeted)
physiological
region.
In
recent
years,
mesoporous
silica
nanoparticles
(MSNs)
have
developed
as
flexible
imaging
platform
tuneable
size/morphology,
abundant
surface
chemistry,
biocompatibility
and
otherwise
useful
physiochemical
properties.
This
review
discusses
MSN
structural
types
synthetic
strategies,
well
methods
for
functionalisation.
Recent
applications
in
are
then
discussed,
with
emphasis
on
magnetic
resonance
optical
modes
together
utility
multimodal
imaging.
Nanomaterials,
Journal Year:
2020,
Volume and Issue:
10(5), P. 916 - 916
Published: May 9, 2020
Mesoporous
silica
nanoparticles
have
been
broadly
applied
as
drug
delivery
systems
owing
to
their
exquisite
features,
such
excellent
textural
properties
or
biocompatibility.
However,
there
are
various
biological
barriers
that
prevent
proper
translation
into
the
clinic,
including:
(1)
lack
of
selectivity
toward
tumor
tissues,
(2)
for
tumoral
cells
and
(3)
endosomal
sequestration
particles
upon
internalization.
In
addition,
open
porous
structure
may
lead
premature
release,
consequently
affecting
healthy
tissues
decreasing
efficacy
treatment.
First,
this
review
will
provide
a
comprehensive
systematic
overview
different
approximations
implemented
mesoporous
overcome
each
barriers.
Afterward,
potential
non-specific
release
from
these
nanocarriers
be
addressed
by
introducing
concept
stimuli-responsive
gatekeepers,
which
endow
with
on-demand
localized
delivery.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(2), P. 2038 - 2067
Published: Jan. 23, 2021
Innovative
multifunctional
nanomaterials
have
attracted
tremendous
interest
in
current
research
by
facilitating
simultaneous
cancer
imaging
and
therapy.
Among
them,
antimony
(Sb)-
bismuth
(Bi)-based
nanoparticles
are
important
species
with
multifunction
to
boost
theranostic
efficacy.
Despite
the
rapid
development,
extensive
previous
work
treated
Sb-
Bi-based
as
mutually
independent
species,
therefore
a
thorough
understanding
of
their
relationship
theranostics
was
lacking.
We
propose
here
that
identical
chemical
nature
Sb
Bi,
being
semimetals,
provides
derived
inherent
for
near-infrared
laser-driven
and/or
X-ray-based
therapy
well
some
other
imparted
functions.
An
overview
recent
progress
on
is
provided
highlight
between
multifunction.
The
this
way
might
shed
light
further
design
smart
theranostics.
