Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101198 - 101198
Published: Aug. 9, 2024
Bioprinting is a groundbreaking technology that enables precise distribution of cell-containing bioinks to construct organoid models accurately reflect the characteristics tumors
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)
Published: Feb. 13, 2024
Abstract Engineered biomaterial scaffolds are becoming more prominent in research laboratories to study drug efficacy for oncological applications vitro, but do they have a place pharmaceutical screening pipelines? The low of cancer drugs phase II/III clinical trials suggests that there critical mechanisms not properly accounted the pre‐clinical evaluation candidates. Immune cells associated with tumor may account some these failures given recent successes immunotherapies; however, few representative platforms immune context as traditional 2D culture is typically monocultures and humanized animal models weakened composition. Biomaterials replicate microenvironmental cues provide relevant model greater vitro complexity. In this review, authors explore pertinent drive progression system, discuss how can be incorporated into hydrogel design cells, describe progress toward precision engineered tissues.
Language: Английский
Citations
3
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: May 21, 2024
Various in vitro three-dimensional (3D) tissue culture models of human and diseased skin exist. Nevertheless, there is still room for the development improvement 3D bioprinted cancer models. The need reproducible bioprinting methods, cell samples, biomaterial inks, bioinks becoming increasingly important. influence viscosity hydrogels on spreading migration most types cells well studied. There are however limited studies In this review, we will outline importance studying various cancers by using We provide an overview advantages disadvantages technologies. emphasize how relates to cells. Lastly, give specific
Language: Английский
Citations
3
JACS Au, Journal Year: 2023, Volume and Issue: 3(8), P. 2086 - 2106
Published: Aug. 11, 2023
Three-dimensional (3D) bioprinting technologies involving photopolymerizable bioinks (PBs) have attracted enormous attention in recent times owing to their ability recreate complex structures with high resolution, mechanical stability, and favorable printing conditions that are suited for encapsulating cells. 3D bioprinted tissue constructs PBs can offer better insights into the tumor microenvironment platforms drug screening advance cancer research. These enable incorporation of physiologically relevant cell densities, tissue-mimetic stiffness, vascularized channels biochemical gradients models, unlike conventional two-dimensional (2D) cultures or other scaffold fabrication technologies. In this perspective, we present emerging techniques using context research, a specific focus on efforts recapitulate complexity microenvironment. We describe approaches various PB formulations compatible these along attempts bioprint models studying migration metastasis, cell–cell interactions, cell–extracellular matrix cancer. discuss limitations identify unexplored opportunities field clinical commercial translation
Language: Английский
Citations
9
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 163, P. 117064 - 117064
Published: April 15, 2023
The increasingly prominent role played by precision, equitable and sustainable diagnosis, particularly of prevalent highly heterogeneous diseases, based on the determination characterization biomarkers cellular origin in liquid biopsy, such as whole cells, their secretomes exosomes they release, is unquestionable. Electrochemical biosensing biosensors, mainly those involving affinity reactions, have emerged recent years competitive analytical alternatives to address these challenging targets versus other existing strategies terms simplicity, cost compatibility with multiplexed or multi-omics point-of-care determinations. This review article aims put table a concise, accurate updated way fundamentals, versatility opportunities provided state-of-the-art electrochemical (2018–2022) for cellular-derived biomarkers. A more critical personal view challenges be faced shorter term where future research advances are expected go also given.
Language: Английский
Citations
7
Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101198 - 101198
Published: Aug. 9, 2024
Bioprinting is a groundbreaking technology that enables precise distribution of cell-containing bioinks to construct organoid models accurately reflect the characteristics tumors
Language: Английский
Citations
2