ACS Nano,
Journal Year:
2024,
Volume and Issue:
19(1), P. 781 - 802
Published: Dec. 21, 2024
Neutrophil
membrane
vesicles
(NMVs)
have
been
successfully
applied
to
control
the
inflammatory
cascade
after
spinal
cord
injury
(SCI)
by
acting
as
an
factor
decoy
front-load
overall
inflammation
regulatory
window;
however,
mechanisms
which
NMVs
regulate
macrophage
phenotypic
shifts
well
their
outcomes
rarely
reported.
In
this
study,
we
demonstrated
"efferocytosis-like"
effect
of
endocytosed
macrophages,
supplementing
TCA
cycle
intermediate
metabolite
α-KG
promoting
glutamine
metabolism,
in
turn
facilitates
oxidative
phosphorylation
and
inhibits
NF-κB
signaling
pathway
reprogram
macrophages
pro-regenerative
phenotype.
Based
on
these
findings,
a
"Trojan
horse"
composite
fiber
scaffold
was
constructed;
comprised
carboxylated
poly-l-lactic
acid
shell
encapsulated
with
core
loaded
brain-derived
neurotrophic
spatiotemporally
modulate
microenvironment
39.23%
sustainably
promote
nerve
regeneration
85.67%.
vivo
experiments
further
confirmed
NMV-coated
scaffolds
regulation
early
innate
immune
continuous
promotion
regeneration.
This
study
not
only
unravels
mechanism
neutrophil
membrane–macrophage
interactions
but
also
provides
strategy
for
coordinating
reprogramming
following
SCI.
Journal of Biomedical Nanotechnology,
Journal Year:
2024,
Volume and Issue:
20(7), P. 1049 - 1061
Published: March 15, 2024
Poly(lactic
acid)
(PLA)
is
a
biodegradable
and
bio-based
polymer
that
has
gained
significant
attention
as
an
environmentally
friendly
alternative
to
traditional
petroleum-based
plastics.
PLA
derived
from
renewable
resources
like
corn
starch
or
sugarcane
through
fermentation
process
converts
sugars
into
lactic
acid,
which
then
synthesized
acid.
As
bioabsorbable
synthetic
polyester,
the
following
benefits,
biodegradability,
source,
non-toxic,
reduced
greenhouse
gas
emissions,
energy
savings.
With
emergence
of
new
manufacturing
technologies,
especially
nanomaterial
technology,
can
be
endowed
with
more
structural
biological
properties.
This
review
discusses
current
application
PLA-based
biomaterials
in
drug
delivery
systems,
medical
fixation
devices,
tissue
regenerative
engineering
scaffolds
Provides
viewpoints
regarding
their
prospective
utilization.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
19(1), P. 781 - 802
Published: Dec. 21, 2024
Neutrophil
membrane
vesicles
(NMVs)
have
been
successfully
applied
to
control
the
inflammatory
cascade
after
spinal
cord
injury
(SCI)
by
acting
as
an
factor
decoy
front-load
overall
inflammation
regulatory
window;
however,
mechanisms
which
NMVs
regulate
macrophage
phenotypic
shifts
well
their
outcomes
rarely
reported.
In
this
study,
we
demonstrated
"efferocytosis-like"
effect
of
endocytosed
macrophages,
supplementing
TCA
cycle
intermediate
metabolite
α-KG
promoting
glutamine
metabolism,
in
turn
facilitates
oxidative
phosphorylation
and
inhibits
NF-κB
signaling
pathway
reprogram
macrophages
pro-regenerative
phenotype.
Based
on
these
findings,
a
"Trojan
horse"
composite
fiber
scaffold
was
constructed;
comprised
carboxylated
poly-l-lactic
acid
shell
encapsulated
with
core
loaded
brain-derived
neurotrophic
spatiotemporally
modulate
microenvironment
39.23%
sustainably
promote
nerve
regeneration
85.67%.
vivo
experiments
further
confirmed
NMV-coated
scaffolds
regulation
early
innate
immune
continuous
promotion
regeneration.
This
study
not
only
unravels
mechanism
neutrophil
membrane–macrophage
interactions
but
also
provides
strategy
for
coordinating
reprogramming
following
SCI.
