Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101761 - 101761
Published: April 11, 2025
PARP
inhibitor
(PARPi)-based
synthetic
lethal
therapies
have
displayed
limited
benefits
in
BRCA-proficient
ovarian
cancer.
To
potentiate
the
application
of
PARPi,
an
ultrasound
contrast
agent
OLA-NDs
for
delivery
PARPi
olaparib
(OLA)
was
established
enhancing
DNA
damage
by
blocking
repair.
were
endowed
with
endogenous
pH-
and
exogenous
(US)-responsiveness
to
target
tumors,
as
well
contrast-enhanced
US
imaging
diagnostic
therapeutic
integration.
could
upregulate
NOX4
induce
oxidative
stress
sensitize
BRCA
wild-type
A2780
cells
through
utilization
ultrasound-targeted
microbubble
destruction
(UTMD).
In
addition,
strategy
further
increased
ROS
production
interfering
mitochondrial
function,
thereby
exacerbating
double-strand
breaks
(DSBs)
inducing
mitochondria-mediated
apoptosis.
As
a
consequence,
combined
UTMD
demonstrated
significant
antitumor
effects
vitro
vivo.
This
amplifying
improved
lethality
promoting
DSBs
apoptosis
reduced
adverse
side
effects,
which
would
provide
new
insight
clinical
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 10, 2025
Targeting
tumor
metabolism
reprogramming
has
demonstrated
a
synergistic
antitumor
effect
in
photodynamic
therapy
of
triple-negative
breast
cancer
(TNBC).
However,
such
combination
therapeutic
regimen
encountered
challenges,
as
limited
photosensitizer
bioavailability
and
severe
drug
toxicity.
Herein,
ultrasmall
metal-organic
frameworks
(MOFs)
nanodots
(MSPC)
that
encapsulate
inhibitors
mitochondria-targeted
photosensitizers
are
designed
fabricated
for
(PDT)
TNBC.
The
MSPC
exhibits
an
acidic-sensitive
release,
leading
to
glutathione
depletion
mitochondrial
respiration
suppression.
Significantly,
substantially
reduces
intracellular
adenosine
triphosphate
(ATP)
levels
by
simultaneously
disrupting
oxidative
phosphorylation
impeding
aerobic
glycolysis.
Therefore,
the
combined
with
inhibitor
increases
stress,
which
improves
efficacy
PDT.
Additionally,
increased
retention
within
tumors,
facilitated
aggregation-enhanced
(AER)
effect,
extends
time
window
long-term
fluorescence/photoacoustic
imaging-guided
PDT
MSPC-sensitized
significantly
suppresses
growth
single-dose
injection
repeatable
In
summary,
these
renal-clearable
tumor-retained
indicate
feasibility
overcoming
resistance
reactive
oxygen
species
induced
metabolic
reprogramming,
thus
holding
significant
implications
boosting
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 26, 2025
Immunogenic
cell
death
(ICD),
a
type
of
regulatory
death,
plays
an
important
role
in
activating
the
adaptive
immune
response.
Activation
tumor-specific
response
is
accompanied
by
surface
exposure
calreticulin
and
heat-shock
proteins,
secretion
adenosine
triphosphate,
release
high
mobility
group
box-1.
In
this
review,
we
summarize
classify
latest
types
ICD
inducers
their
molecular
mechanisms,
discuss
effects
potential
applications
inducing
chemotherapy
drugs,
targeted
oncolytic
viruses
clinical
research.
We
also
explore
epigenetic
modifiers
induction
ICD,
clarify
synergistic
anti-tumor
nano-pulse
stimulation,
radiosensitizers
for
radiotherapy,
photosensitizers
photodynamic
therapy,
photothermal
other
physical
combined
with
radiotherapy
induced-ICD,
multimodal
immunotherapy.
addition,
elucidate
mechanism
detail,
including
calcium
imbalance,
mitochondrial
stress,
interactions
tumor
microenvironment.
Ultimately,
review
aims
to
offer
deeper
insight
into
factors
mechanisms
provide
theoretical
basis
future
development
ICD-based
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101761 - 101761
Published: April 11, 2025
PARP
inhibitor
(PARPi)-based
synthetic
lethal
therapies
have
displayed
limited
benefits
in
BRCA-proficient
ovarian
cancer.
To
potentiate
the
application
of
PARPi,
an
ultrasound
contrast
agent
OLA-NDs
for
delivery
PARPi
olaparib
(OLA)
was
established
enhancing
DNA
damage
by
blocking
repair.
were
endowed
with
endogenous
pH-
and
exogenous
(US)-responsiveness
to
target
tumors,
as
well
contrast-enhanced
US
imaging
diagnostic
therapeutic
integration.
could
upregulate
NOX4
induce
oxidative
stress
sensitize
BRCA
wild-type
A2780
cells
through
utilization
ultrasound-targeted
microbubble
destruction
(UTMD).
In
addition,
strategy
further
increased
ROS
production
interfering
mitochondrial
function,
thereby
exacerbating
double-strand
breaks
(DSBs)
inducing
mitochondria-mediated
apoptosis.
As
a
consequence,
combined
UTMD
demonstrated
significant
antitumor
effects
vitro
vivo.
This
amplifying
improved
lethality
promoting
DSBs
apoptosis
reduced
adverse
side
effects,
which
would
provide
new
insight
clinical
