Microneedles for anti-aging skincare: preparation, properties and applications DOI

Khan Manqoosh Awan,

Haojie Yu, Li Wang

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: 41, P. 110740 - 110740

Published: Oct. 18, 2024

Language: Английский

Microneedles at the Forefront of Next Generation Theranostics DOI Creative Commons
Chan Wang, Yuan Yang, Jiaqi Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated platforms. Microneedles enhance access biomarkers via interstitial fluid, enabling real‐time monitoring physiological conditions, such as glucose hormone levels, thus facilitating continuous health tracking. The evolution design solid dissolvable forms broadens their utility mere complex sensing applications, including insulin for diabetes management, vaccination, gene therapy. paper delves into integration microneedles wearable technologies, highlighting role closed‐loop systems that combine dynamic, precise delivery. By addressing gaps literature regarding integrated treatment capabilities, this underscores pivotal personalizing medicine. It concludes visionary perspective on future trajectory technology, emphasizing potential revolutionize strategies through enhanced efficacy, safety, patient compliance.

Language: Английский

Citations

3
ATP-adenosine axis regulation combined with microneedle assisted photoimmunotherapy to boost the immunotherapy efficiency DOI

Chaonan Shi,

Minglong Chen,

Xiaodie Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 1 - 12

Published: Jan. 24, 2024

Language: Английский

Citations

18
A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles DOI

Qixin Zhou,

Xiaodan Li, Nan Gao

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(4), P. 1007 - 1021

Published: Jan. 1, 2024

Antibacterial nanocomposite-integrated microneedles were designed for infected diabetic wound therapy. The nanocomposite could be destroyed by high glucose and exerted a powerful synergistic antibacterial effect against bacterial infections.

Language: Английский

Citations

17
Dissolving microneedles: drug delivery and disease treatment DOI

Yanling Zhuo,

F.Z. Wang, Qizhuang Lv

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114571 - 114571

Published: Feb. 1, 2025

Language: Английский

Citations

2
State-of-the-art strategies to enhance the mechanical properties of microneedles DOI
Xinyu Zhang,

Chunxian Zhou,

Tianxiang Chen

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 663, P. 124547 - 124547

Published: Aug. 2, 2024

Language: Английский

Citations

9
Dissolving microneedles for transdermal drug delivery in cancer immunotherapy DOI

Maya Xiang,

Chunli Yang, Li Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(24), P. 5812 - 5822

Published: Jan. 1, 2024

Dissolving microneedles mediated immunotherapeutics delivery for cancer treatment.

Language: Английский

Citations

8
Functional hyaluronic acid microneedles for skin photoaging based on collagen induction and oxidative stress regulation strategies DOI

Zhimin Tang,

Zheng Liu, Youliang Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134080 - 134080

Published: July 27, 2024

Language: Английский

Citations

8
Simple and user-friendly nucleolus imaging with ultra-narrow bandwidth red emission carbon dots DOI

Seyed-Omid Kalji,

Majid Sadeghizadeh,

Khosro Khajeh

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112659 - 112659

Published: Jan. 1, 2025

Language: Английский

Citations

1
Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches with Antimicrobial and Immunomodulating Properties for Oral Mucosa Disease Treatment DOI
Xuancheng Zhang,

Guannan Zhong,

Shiyuan Peng

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Oral ulcer wounds are difficult to heal due bacterial infections, persistent inflammatory responses, and excessive reactive oxygen species (ROS). Therefore, the elimination of bacteria, removal ROS, reduction inflammation prerequisites for treatment mouth wounds. In this study, oligomeric proanthocyanidins (OPC) 3-(aminomethyl)phenylboronic acid-modified hyaluronic acid (HP) were used form polymer gels through dynamic covalent borate bonds. Minocycline hydrochloride (MH) was then loaded into gel, a multifunctional MH/OPC-HP microneedles (MNs) with ROS-responsive properties prepared using vacuum method. The MNs can rapidly release MH in diffusive manner sustainably OPC response ROS. gel-based extended retention oral ulcers, leading prolonged ROS scavenging effects. Cytocompatibility hemocompatibility tests showed that had good biocompatibility. Antibacterial experiments demonstrated exhibited excellent antibacterial vitro indicated could effectively clear reduce oxidative stress damage, inhibit M1-type macrophage polarization, induce M2-type polarization. Furthermore, vivo revealed pro-inflammatory cytokines, promote neovascularization, accelerate epithelial healing significantly rat model wound infection. summary, hold promise as therapeutic strategy enhancing

Language: Английский

Citations

1
Assessing the safety of topical minoxidil through disproportionality analysis of FAERS reports DOI
Yanbo Li, Bo Liu, Wei Wu

et al.

Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Topical minoxidil, approved by the FDA in 1980s, has been widely used to manage androgenetic alopecia. While effective, several adverse events (AEs) related its use, especially those not well-documented on product labels, remain a concern. This study aimed evaluate safety of topical minoxidil analyzing AEs reported Adverse Event Reporting System (FAERS) from 2004 2024, focusing identifying potential risk signals highlighted current labels. event reports（AERs） FAERS, where was identified as primary suspect, were analyzed. Disproportionality analysis methods, Odds Ratio (ROR), Proportional (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-Item Gamma Poisson Shrinker (MGPS), assess relationship between AEs. Among 45,130 reports, most males (50.88%) showed significant increase incidents since 2015. Newly AEs, such application site acne cysts, observed. These are well represented The previously unreported linked underscoring need for updated patient information regulatory reassessment enhance inform clinical practices.

Language: Английский

Citations

1