Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 15, 2024
Abstract
The
treatment
of
brain
diseases
has
always
been
the
focus
attention.
Due
to
presence
blood‐brain
barrier
(BBB),
most
small
molecule
drugs
are
difficult
reach
brain,
leading
undesirable
therapeutic
outcomes.
Recently,
nanomedicines
that
can
cross
BBB
and
precisely
target
lesion
sites
have
emerged
as
thrilling
tools
enhance
early
diagnosis
treat
various
intractable
disorders.
Extensive
research
shown
reactive
oxygen
species
(ROS)
play
a
crucial
role
in
occurrence
progression
diseases,
including
tumors
neurodegenerative
(NDDs)
such
Alzheimer's
disease,
Parkinson's
stroke,
or
traumatic
injury,
making
ROS
potential
target.
In
this
review,
on
structure
function
well
mechanisms
first
elaborated
through
which
nanomedicine
traverses
it.
Then,
recent
studies
production
summarized
photodynamic
therapy
(PDT),
chemodynamic
(CDT),
sonodynamic
(SDT)
for
treating
tumors,
depletion
NDDs.
This
provides
valuable
guidance
future
design
ROS‐targeted
disease
treatment.
ongoing
challenges
perspectives
developing
nanomedicine‐based
management
also
discussed
outlined.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(4)
Published: July 1, 2024
Due
to
its
chronic
nature
and
complex
pathophysiology,
inflammatory
bowel
disease
(IBD)
poses
significant
challenges
for
treatment.
The
long-term
therapies
patients,
often
diagnosed
between
the
ages
of
20
40,
call
innovative
strategies
target
inflammation,
minimize
systemic
drug
exposure,
improve
patients'
therapeutic
outcomes.
Among
plethora
currently
pursued,
bioinspired
bioderived
nano-based
formulations
have
garnered
interest
their
safety
versatility
in
management
IBD.
Bioinspired
nanomedicine
can
host
deliver
not
only
small
molecules
but
also
biotherapeutics,
be
made
gastroresistant
mucoadhesive
or
mucopenetrating
and,
these
reasons,
are
largely
investigated
oral
administration,
while
surprisingly
less
rectal
delivery,
recommended
first-line
treatment
approach
several
IBD
patients.
use
nanocarriers,
mostly
extracellular
vesicles
(EVs),
endowed
with
unique
homing
abilities,
is
still
infancy
respect
arsenal
under
investigation
An
emerging
source
EVs
suited
administration
ingesta,
that
is,
plants
milk,
thanks
remarkable
ability
resist
harsh
environment
upper
gastrointestinal
tract.
Inspired
by
unparalleled
properties
natural
biomaterials,
sophisticated
avenues
enhancing
efficacy
advancing
precision
medicine
approaches
care
taking
shape,
although
bottlenecks
arising
either
from
complexity
designed
lack
a
clear
regulatory
pathway
hinder
smooth
efficient
translation
clinics.
This
article
categorized
under:
Nanotechnology
Approaches
Biology
>
Nanoscale
Systems
Biology.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
29, P. 101332 - 101332
Published: Nov. 8, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
recurrent
with
an
increasing
incidence
year
by
year.
At
present,
no
safe
and
effective
treatment
for
IBD
exists.
Thus,
there
urgent
need
to
create
new
therapeutic
options
that
have
decreased
adverse
effects
positive
clinical
efficacy.
A
range
of
nanomaterials
fueled
the
advancement
nanomedicine
in
recent
years,
which
establishing
more
appealing
prospective
approaches
IBD.
However,
traditional
synthetic
still
some
problems
drug
delivery
process,
such
as
weak
targeting
ability
vectors,
difficulty
escaping
immune
surveillance,
poor
biosecurity.
Natural
sources
biological
been
identified
solve
above
problems.
system
based
on
bionic
technology
expected
achieve
breakthrough
targeted
therapy
nanotechnology
due
its
organic
integration
low
immunogenicity
natural
materials
controllability
versatility
nanocarrier
design.
We
begin
this
review
outlining
fundamental
traits
both
inflammatory
healthy
intestinal
microenvironments.
Subsequently,
we
latest
application
cell-derived
therapy.
Finally,
discuss
development
prospects
challenges
translation.
Biomimetic
nanotherapy
believed
offer
strategy
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Abstract
Engineered
bacterial
therapy
holds
enormous
potential
for
treating
intestinal
diseases,
employing
synthetic
biology
techniques
to
achieve
localized
drug
delivery
within
intestines.
However,
effective
of
engineered
bacteria
lesion
sites
and
ensuring
sustained
colonization
remain
challenging.
Here,
a
mucus
encapsulated
microsphere
gel
(MM)
system
is
developed
encapsulate
genetically
capable
detecting
enteritis.
The
MM
features
an
external
mucosal
coating
composed
hyaluronic
acid
epigallocatechin
gallate,
along
with
internal
microspheres
highly
biocompatible
polyserine
modified
alginates
encapsulating
the
probiotics.
effectively
protects
harsh
environment
in
stomach
significantly
improves
adhesion
probiotics,
extending
up
24
h,
does
not
affect
entry
biomarker
or
release
Avcystatin.
It
exhibits
notable
diagnostic
therapeutic
efficacy
inflammatory
bowel
disease
models,
thus
facilitating
advancement
live
biotherapeutic
products
toward
clinical
application.
Chinese Medical Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
Nanomedicine
is
an
interdisciplinary
area
that
utilizes
nanoscience
and
technology
in
the
realm
of
medicine.
Rapid
advances
science
have
propelled
medical
sector
into
a
new
era.
The
most
commonly
used
nanotechnology
field
medicine
nanoparticles.
Due
to
their
unique
physicochemical
properties,
nanoparticles
offer
significant
benefits
precision
for
diseases
such
as
inflammatory
bowel
disease
cannot
be
effectively
treated
by
existing
approaches.
has
emerged
highly
active
research
field,
with
extensive
scientific
technological
studies
being
carried
out,
well
growing
international
competition
commercialization
this
field.
accumulation
expertise
key
technologies
relating
nanomedicine
would
provide
strategic
advantages
development
cutting-edge
techniques.
This
review
presented
comprehensive
analysis
primary
uses
medicine,
including
recent
application
diagnosis
treatment
disease.
Furthermore,
we
discussed
challenges
possibilities
associated
clinical
settings.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 15, 2024
Abstract
The
treatment
of
brain
diseases
has
always
been
the
focus
attention.
Due
to
presence
blood‐brain
barrier
(BBB),
most
small
molecule
drugs
are
difficult
reach
brain,
leading
undesirable
therapeutic
outcomes.
Recently,
nanomedicines
that
can
cross
BBB
and
precisely
target
lesion
sites
have
emerged
as
thrilling
tools
enhance
early
diagnosis
treat
various
intractable
disorders.
Extensive
research
shown
reactive
oxygen
species
(ROS)
play
a
crucial
role
in
occurrence
progression
diseases,
including
tumors
neurodegenerative
(NDDs)
such
Alzheimer's
disease,
Parkinson's
stroke,
or
traumatic
injury,
making
ROS
potential
target.
In
this
review,
on
structure
function
well
mechanisms
first
elaborated
through
which
nanomedicine
traverses
it.
Then,
recent
studies
production
summarized
photodynamic
therapy
(PDT),
chemodynamic
(CDT),
sonodynamic
(SDT)
for
treating
tumors,
depletion
NDDs.
This
provides
valuable
guidance
future
design
ROS‐targeted
disease
treatment.
ongoing
challenges
perspectives
developing
nanomedicine‐based
management
also
discussed
outlined.
