Copper(II) Complexes with 1-(Isoquinolin-3-yl)heteroalkyl-2-ones: Synthesis, Structure and Evaluation of Anticancer, Antimicrobial and Antioxidant Potential DOI Open Access
Łukasz Balewski, Tomasz Plech, Izabela Korona‐Głowniak

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 8 - 8

Published: Dec. 19, 2023

Four copper(II) complexes, C1–4, derived from 1-(isoquinolin-3-yl)heteroalkyl-2-one ligands L1–4 were synthesized and characterized using an elemental analysis, IR spectroscopic data as well single crystal X-ray diffraction for complex C1. The stability of complexes C1–4 under conditions mimicking the physiological environment was estimated UV-Vis spectrophotometry. antiproliferative activity both compounds evaluated MTT assay on four human cancer cell lines, A375 (melanoma), HepG2 (hepatoma), LS-180 (colon cancer) T98G (glioblastoma), a non-cancerous line, CCD-1059Sk (human normal skin fibroblasts). Complexes showed greater potency against HepG2, LS180 lines than etoposide (IC50 = 5.04–14.89 μg/mL vs. IC50 43.21–>100 μg/mL), while free remained inactive in all lines. prominent compound C2 appeared to be more selective towards cells compared with C1, C3 C4. treatment resulted sub-G1 G2/M cycle arrest, respectively, which accompanied by DNA degradation. Moreover, non-cytotoxic doses synergistically enhanced cytotoxic effects chemotherapeutic drugs, including etoposide, 5-fluorouracil temozolomide, cells. antimicrobial activities L2–4 their C2–4 different types Gram-positive bacteria, Gram-negative bacteria yeast species. No correlation found between results experiments. antioxidant determined DPPH ABTS radical scavenging methods. Antiradical tests revealed that among investigated compounds, C4 possessed strongest properties. Finally, ADME technique used determine physicochemical drug-likeness properties obtained complexes.

Language: Английский

Carbon nanotube-mediated platinum-based drug delivery for the treatment of cancer: Advancements and future perspectives DOI
Mohammad Sameer Khan, B.H. Jaswanth Gowda, Nazeer Hasan

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 206, P. 112800 - 112800

Published: Jan. 26, 2024

Language: Английский

Citations

24
Development of Platinum Complexes for Tumor Chemoimmunotherapy DOI
S. Jin, Yan Guo, Xiaoyong Wang

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(10)

Published: Jan. 3, 2024

Abstract Platinum complexes are potential antitumor drugs in chemotherapy. Their impact on tumor treatment could be greatly strengthened by combining with immunotherapy. Increasing evidences indicate that the activity of platinum is not limited to chemical killing effects, but also extends immunomodulatory actions. This review introduced general concept chemoimmunotherapy and summarized progress as chemoimmunotherapeutic agents recent years. developed into inducers immunogenic cell death, blockers immune checkpoint, regulators signaling pathway, modulators microenvironment, etc. The synergy between chemotherapeutic effects reinforces complexes, helps them circumvent drug resistance systemic toxicity. exploration for may create new opportunities revive discovery metal anticancer drugs.

Language: Английский

Citations

16
Series of Desloratadine Platinum(IV) Hybrids Displaying Potent Antimetastatic Competence by Inhibiting Epithelial–Mesenchymal Transition and Arousing Immune Response DOI
Ming Zhang, Yan Chen, Zhifang Liu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(3), P. 2031 - 2048

Published: Jan. 17, 2024

Metastasis is the major obstacle to survival of cancer patients. Herein, a series new desloratadine platinum(IV) conjugates with promising antiproliferative and antimetastatic activities were developed evaluated. The candidate complex caused significant DNA damage stimulated mitochondrial apoptosis through Bcl-2/Bax/caspase3 pathway. Then, it suppressed epithelial–mesenchymal transition (EMT) process in tumors effectively NMT-1/HPCAL1 β-catenin signaling. Subsequently, angiogenesis was inhibited downregulation key proteins HIF-1α, VEGFA, MMP-9, CD34. Moreover, antitumor immunity aroused by synergism EMT reversion decrease histamine level; then, macrophage polarization from M2- M1-type increase CD4+ CD8+ T cells triggered simultaneously tumors.

Language: Английский

Citations

14
Visible and Red Light-Triggered Anticancer Profile of a Ferrocene-Re(I)-Tricarbonyl Conjugate: Experimental and Theoretical Studies DOI
Rajesh Kushwaha, Aarti Upadhyay, Silda Peters

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(23), P. 12226 - 12238

Published: May 30, 2024

We have red-shifted the light absorbance property of a Re(I)-tricarbonyl complex via distant conjugation ferrocene moiety and developed novel ReFctp, [Re(Fctp)(CO)3Cl], where Fctp = 4′-ferrocenyl-2,2′:6′,2″-terpyridine. ReFctp showed green to red absorption ability blue emission, indicating its potential for photodynamic therapy (PDT) application. The introduced ferrocene-based transitions, which lie at higher wavelength within PDT therapeutic window. time-dependent density functional theory excited state calculations revealed an efficient intersystem crossing is helpful PDT. elicited both type I II pathways reactive oxygen species (ROS) generation facilitated NADH (1,4-dihydro-nicotinamide adenine dinucleotide) oxidation upon exposure visible light. Importantly, effective penetration through layers clinically relevant 3D multicellular tumor spheroids localized primarily in mitochondria (Pearson's correlation coefficient, PCC 0.65) A549 cancer cells. produced more than 20 times phototoxicity (IC50 ∼1.5 μM) by inducing ROS altering mitochondrial membrane cells nonferrocene analogue Retp, [Re(CO)3(tp)Cl], tp 2,2′:6′,2″-terpyridine. induced apoptotic mode cell death with notable photocytotoxicity index (PI, PI IC50dark/IC50light) selectivity (SI, SI normal cell's IC50dark/cancer IC50light) range 25–33.

Language: Английский

Citations

9
Red and NIR light-triggered enhancement of anticancer and antibacterial activities of dinuclear Co(ii)-catecholate complexes DOI

Jyotirmoy Dutta,

Are Varshini,

Sri Ganga Padaga

et al.

Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Photoactive complexes of bioessential 3d metals, activable within the phototherapeutic window (650-900 nm), have gained widespread interest due to their therapeutic potential. Herein, we report synthesis, characterization, and light-enhanced anticancer antibacterial properties four new dinuclear Co(II) complexes: [Co(phen)(cat)]2 (Co-1), [Co(dppz)(cat)]2 (Co-2), [Co(phen)(esc)]2 (Co-3), [Co(dppz)(esc)]2 (Co-4). In these complexes, phen (1,10-phenanthroline) dppz (dipyrido[3,2-a:2',3'-c]phenazine) act as neutral N,N-donor ligands, while cat2- esc2- serve O,O-donor catecholate ligands derived from catechol (1,2-dihydroxybenzene) esculetin (6,7-dihydroxy coumarin). Their high-spin paramagnetic nature dimeric identity in solution were confirmed by magnetic susceptibility, UV-visible, emission, mass spectral data. Co-1-Co-4 exhibited an absorption band 600-850 nm range, originating a charge transfer transition. The electrically demonstrated sufficient stability both dark under irradiated conditions. Co-2 Co-4 notable toxicity towards A549 lung carcinoma cells, with potency increasing significantly brief (5 min) exposure 660 (red) 808 (NIR) laser light (IC50 ∼ 8.9 14.9 μM). Notably, normal NIH-3T3 fibroblast cells was minimal. Cellular assays highlighted that induced cell death followed apoptotic pathway, primarily mitochondrial damage. also significant against Gram-(+) S. aureus Gram-(-) P. aeruginosa, effectiveness enhanced upon irradiation (MIC 15-142 increase efficacies attributed generation cytotoxic singlet oxygen (1O2) species red/NIR exposure. NIR produced more pronounced effects compared nm. This study is first on cobalt exhibiting red light-triggered enhancement activities, illuminating path for development long-wavelength absorbing efficacy.

Language: Английский

Citations

1
Antitumor Effect of Platinum-Modified STING Agonist MSA-2 DOI Creative Commons
Mo Wang,

Ya Cai,

He Tian

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(2), P. 2650 - 2656

Published: Jan. 3, 2024

The stimulator of interferon genes (STING)-activated innate immune pathway is strong and durable for tumor immunotherapy. MSA-2 an available non-nucleotide human STING agonist that promotes the immunotherapy activation. However, strategies remolding improving effects are value clinical applications. Here, we synthesized platinum salt-modified (MSA-2-Pt) due to salt being a classic chemotherapeutic drug. We found MSA-2-Pt could achieve double-effect antitumor immunotherapy, including inducing cell death by activating MSA-2. In colon carcinoma MC38 model (sensitive checkpoint tumor) melanoma B16F10 (poorly immunogenic highly aggressive tumor), had good effect, which was little better than with intratumor injections. results present promising strategy activation in broadening platinum-based drugs.

Language: Английский

Citations

8
Macromolecules incorporating transition metals in the treatment and detection of cancer and infectious diseases: Progress over the last decade DOI
Ahmad Abd‐El‐Aziz, Saleh A. Ahmed, Xinyue Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215732 - 215732

Published: March 28, 2024

Language: Английский

Citations

5
Dinuclear Rhenium(I) Tricarbonyl Complexes as Anticancer Drug Candidates DOI Creative Commons
Nicolás Montesdeoca, Reema L. Borkar, Malaichamy Sathiyendiran

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(32)

Published: April 4, 2024

Abstract Cancer is one of the deadliest diseases worldwide. Chemotherapy remains most dominant forms for anticancer treatment. Despite their clinical success, used chemotherapeutic agents are associated with severe side effect and pharmacological limitations. To overcome these drawbacks there a need development new types agents. Herein, chemical synthesis biological evaluation dinuclear rhenium(I) complexes as potential drug candidates proposed. The metal were found to be internalized by an energy dependent endocytosis pathway, primary accumulating in mitochondria. demonstrated induce cell death against variety cancer cells micromolar range through apoptosis. lead compound showed eradicate pancreatic carcinoma multicellular tumor spheroid at concentrations.

Language: Английский

Citations

5
Integrated and hyaluronic acid-coated mesoporous silica nanoparticles conjugated with cisplatin and chlorin e6 for combined chemo and photodynamic cancer therapy DOI
Yi Li, V.H. Giang Phan, Zhouyi Pan

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 220, P. 113426 - 113426

Published: Sept. 6, 2024

Language: Английский

Citations

5
Platinum(ii) complexes of aryl guanidine-like derivatives as potential anticancer agents: between coordination and cyclometallation DOI Creative Commons

Patrick O’Sullivan,

Viola Previtali,

Brendan Twamley

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3427 - 3438

Published: Jan. 1, 2025

The preparation of a wide variety Pt( ii ) complexes with aryl guanidines and their potential application as anticancer agents have been explored.

Language: Английский

Citations

0