Synthesis,
Journal Year:
2024,
Volume and Issue:
56(12), P. 1896 - 1904
Published: Feb. 22, 2024
Abstract
A
four-stage
method
for
the
synthesis
of
2H-imidazole-derived
push-pull
fluorophores
was
developed.
The
synthesized
compounds
are
characterized
by
absorption
in
range
250–400
nm,
emission
up
to
617
and
quantum
yields
99%.
Compounds
bearing
a
tetraphenylethylene
fragment
demonstrated
AIE
effect
solution
with
water
fraction
fw
>90%
significant
increase
intensity
20
times
22%.
ICT
states
these
were
confirmed
calculating
excited
state
dipole
moments
(>23D).
reported
synthetic
enables
fine-tuning
fluorescent
properties
developed
photoactive
molecular
systems
varying
donor
fragments.
obtained
could
be
particular
interest
design
organic
hybrid
materials.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Abstract
Although
classical
fluorescent
dyes
feature
advantages
of
high
quantum
yield,
tunable
“OFF‐ON”
fluorescence,
and
modifiable
chemical
structures,
etc.,
their
bio‐applications
in
deep
tissue
remains
challenging
due
to
excessively
short
emission
wavelength
(that
may
lead
superficial
penetration
depth).
Therefore,
there
is
a
pressing
need
for
pushing
the
from
visible
region
NIR‐II
window.
As
representative
dye,
2′,7′‐Dichlorofluorescein
(
DCF
),
derivative
Fluorescein,
selected
rationally
engineered
develop
novel
platform,
CR‐OH
,
which
exhibits
substantial
red‐shift
region.
This
achievement
attributed
molecular
modification
strategies
that
include
extending
π‐conjugation,
enhancing
rigidity,
incorporating
strong
electron‐withdrawing
groups.
Furthermore,
based
on
this
developed
fluorescence
probe
photothermal
nanoagent
are
successfully
constructed
unlock
its
bio‐application
imaging
endogenous
O
2
·–
fluctuations
CIRI
model
first
time,
as
well
effective
therapy
4T1
tumors
with
conversion
efficiency
(44.0%).
Significantly,
work
overcomes
limitation
dyes,
effectively
unlocking
applications
diagnosis
treatment
early
disease
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 24, 2025
Gold
nanoclusters
emitting
in
the
second
biological
window
(NIR-II-AuNCs)
have
gained
significant
interest
for
their
potential
deep-tissue
bioimaging
and
biosensing
applications
due
to
partial
transparency
reduced
autofluorescence
of
tissues
this
spectral
range.
However,
limited
understanding
how
environment
affects
luminescent
properties
might
hinder
use
biosensing.
In
study,
we
investigated
emission
NIR-II-AuNCs
when
interacting
internalizing
into
live
cells
including
macrophages,
fibroblasts,
cancer
cell
lines,
revealing
substantial
alterations
luminescence.
A
systematic
comparison
between
control
vitro
experiments
concluded
that
disruption
surface
ligands
is
main
factor
responsible
these
alterations.
within
cellular
environments
may
also
be
influenced
by
other
interactions,
aggregation
or
complexation
with
proteins.
Furthermore,
corroborated
spectroscopic
modifications
at
vivo
level,
providing
additional
evidence
environmental
sensitivity
NIR-II-AuNCs.
The
results
obtained
study
contribute
a
deeper
luminescence
mechanisms
living
are
crucial
optimization
as
reliable
tools
imaging
diagnostics.
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(5), P. 3679 - 3691
Published: Feb. 23, 2024
The
development
of
new
fluorescent
organic
probes
effective
in
the
NIR-II
region
is
currently
a
fast-growing
field
and
represents
challenge
domain
medical
imaging.
In
this
study,
we
have
designed
synthesized
an
innovative
series
aza-boron
dipyrromethenes
emitting
region.
We
investigated
effect
different
water-solubilizing
groups
not
only
on
photophysical
properties
compounds
but
also
their
vitro
vivo
performance
after
bioconjugation
to
antibody
trastuzumab.
Remarkably,
discovered
that
most
lipophilic
compound
unexpectedly
displayed
favorable
bioconjugation.
This
underlines
profound
influence
fluorophore
functionalization
approach
can
efficiency
resulting
imaging
agent.
