Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Abstract
Management
of
hard‐to‐heal
wounds
often
requires
specialized
care
that
surpasses
the
capabilities
conventional
treatments.
Even
most
advanced
commercial
products
lack
functionality
to
meet
needs
wounds,
especially
those
complicated
by
active
infection,
extreme
bleeding,
and
chronic
inflammation.
The
review
explores
how
supramolecular
nanovesicles
nanoparticles—such
as
dendrimers,
micelles,
polymersomes,
lipid‐based
nanocarriers—can
be
key
introducing
wound
healing
monitoring
properties
address
complex
wounds.
Their
potential
enable
functions
essential
for
next‐generation
products—such
hemostatic
functions,
transdermal
penetration,
macrophage
polarization,
targeted
delivery,
controlled
release
pharmaceutical
ingredients
(antibiotics,
gaseous
products,
anti‐inflammatory
drugs,
growth
factors)—is
discussed
via
an
extensive
overview
recent
reports.
These
studies
highlight
integration
systems
in
is
crucial
advancing
toward
a
new
generation
addressing
significant
gaps
current
management
practices.
Current
strategies
improvements
regarding
personalized
therapies,
promising
critically
evaluated
but
underexplored
polymer‐based
nanovesicles,
including
polymersomes
proteinosomes,
healing.
Chronic
wounds
are
a
major
health
problem
because
of
delayed
healing
and
cause
hardships
for
the
patient.
The
infection
present
in
these
plays
role
wound
healing.
Silver
dressings
have
been
used
decades,
beginning
1960s
with
silver
sulfadiazine
prevention
burn
wounds.
Since
that
time,
there
has
large
number
commercial
cleared
FDA
approval.
In
this
review,
we
examine
literature
involving
vitro,
vivo,
clinical
studies
attempt
to
glean
important
characteristics
treating
infected
primary
presentation
is
form
detailed
tables.
narrative
part
review
focuses
on
different
types
dressings,
including
supporting
matrix,
release
into
surroundings,
their
toxicity.
Though
many
chronic
using
discuss,
it
difficult
compare
performances
directly
differences
study
protocols.
We
conclude
can
assist
healing,
though
provide
general
treatment
guidelines.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
Abstract
Background
Infected
wounds
are
a
major
health
problem
as
infection
can
delay
wound
healing.
Wound
dressings
play
an
important
part
in
care
by
maintaining
suitable
environment
that
promotes
Silver
sulfadiazine
have
been
used
for
preventing
burn
wounds.
Presently,
there
many
commercial
silver
obtained
FDA
clearance.
Results
In
this
study,
we
report
on
novel
dressing
using
microporous
aluminosilicate
zeolites,
termed
ABF-XenoMEM.
and
zinc
ion
encapsulated
the
zeolite
supercages.
We
show
silver-zinc
(AM30)
alone
is
effective
at
inhibiting
biofilm
formation.
The
encapsulation
protects
from
rapidly
precipitating
biological
fluids.
exploit
negatively
charged
surface
to
associate
positively
quaternary
ammonium
ions
(quat)
with
zeolite.
combination
of
AM30
quat
enhances
antimicrobial
activity.
colloidal
nature
materials
makes
it
possible
make
uniform
deposits
extracellular
matrix
membrane
develop
final
(ABF-XenoMEM).
optimum
loading
silver,
was
found
be
30,
6
220
µg/cm2.
Using
colony
model,
activity
ABF-XenoMEM
compared
four
well-studied
silver-based
towards
mature
biofilms
Pseudomonas
aeruginosa
(PAO1)
methicillin-resistant
Staphylococcus
aureus
(MRSA).
Cytotoxicity
examined
HepG2
cells
MTT
assay.
Conclusion
This
study
shows
competitive
extensively
demonstrates
model
nanozeolite-entrapped
antimicrobials
potential
alleviating
biofilm-infected
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Abstract
Management
of
hard‐to‐heal
wounds
often
requires
specialized
care
that
surpasses
the
capabilities
conventional
treatments.
Even
most
advanced
commercial
products
lack
functionality
to
meet
needs
wounds,
especially
those
complicated
by
active
infection,
extreme
bleeding,
and
chronic
inflammation.
The
review
explores
how
supramolecular
nanovesicles
nanoparticles—such
as
dendrimers,
micelles,
polymersomes,
lipid‐based
nanocarriers—can
be
key
introducing
wound
healing
monitoring
properties
address
complex
wounds.
Their
potential
enable
functions
essential
for
next‐generation
products—such
hemostatic
functions,
transdermal
penetration,
macrophage
polarization,
targeted
delivery,
controlled
release
pharmaceutical
ingredients
(antibiotics,
gaseous
products,
anti‐inflammatory
drugs,
growth
factors)—is
discussed
via
an
extensive
overview
recent
reports.
These
studies
highlight
integration
systems
in
is
crucial
advancing
toward
a
new
generation
addressing
significant
gaps
current
management
practices.
Current
strategies
improvements
regarding
personalized
therapies,
promising
critically
evaluated
but
underexplored
polymer‐based
nanovesicles,
including
polymersomes
proteinosomes,
healing.
