Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment DOI
Sai Kiran S. S. Pindiprolu,

Madhu Tanya Singh,

Magham Sai Varshini

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Mesenchymal stem cell extracellular vesicle vascularization bioactivity and production yield are responsive to cell culture substrate stiffness DOI Creative Commons

Emily H. Powsner,

Stephanie M. Kronstadt,

Kristin Nikolov

et al.

Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Mesenchymal stem cell‐derived extracellular vesicles (MSC EVs) are an attractive therapeutic option for regenerative medicine applications due to their inherently pro‐angiogenic and anti‐inflammatory properties. However, reproducible cost‐effective production of highly potent MSC EVs is challenging, limiting translational potential. Here, we investigated whether the well‐characterized responsiveness MSCs mechanical environment—specifically, substrate stiffness—could be exploited generate with increased bioactivity without need biochemical priming or genetic manipulation. Using polydimethylsiloxane bone marrow‐derived (BM‐MSCs), show that decreasing stiffness substrates as low 3 kPa significantly improves measured by tube formation gap closure assays. We also demonstrate lower EV overall yield, important clinical translation. Furthermore, establish mechanoresponsiveness induced pluripotent (iMSC) comparability BM‐MSC EVs, again using With this data, confirm iMSCs' feasibility alternative, renewable cell source reduced donor variability. Overall, these results suggest utilizing a promising, simple, potentially scalable approach does not require exogenous cargo extraneous reagents EVs.

Language: Английский

Citations

0
Understanding the Extracellular Vesicles in Helminths DOI
Antonio Marcilla, Christian M. Sánchez‐López, Aránzazu González

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dermal Fibroblast-Derived Exosomes Promotes Bone-to-Tendon Interface Healing of Chronic Rotator Cuff Tear in Rabbit Model DOI
Jian Han,

G.Y. Li,

Shen-Yun Fang

et al.

Arthroscopy The Journal of Arthroscopic and Related Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Glycoengineered Stem Cell-Derived Extracellular Vesicles for Targeted Therapy of Acute Kidney Injury DOI
S. H. Kim, Chan Ho Kim, C Lee

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123165 - 123165

Published: Feb. 4, 2025

Language: Английский

Citations

0
Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment DOI
Sai Kiran S. S. Pindiprolu,

Madhu Tanya Singh,

Magham Sai Varshini

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0