International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125151 - 125151
Published: Dec. 1, 2024
Language: Английский
Biomaterials Advances, Journal Year: 2025, Volume and Issue: 173, P. 214259 - 214259
Published: March 5, 2025
Language: Английский
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0
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: April 26, 2025
The overuse of antibiotics has increased the prevalence drug-resistant bacteria in periodontitis. "Sentinel" gingival fibroblasts, stimulated by pathogenic bacteria, continue to release signaling factors that affect stem cell repair and recruit immune cells, resulting persistent inflammation periodontal tissues, eventually leading loosening loss teeth. Periodontal cause surface hypoxia, fibroblasts inflammatory microenvironment express HIF-1α, promoting hypoxic areas pockets. No drug delivery system is available for region We synthesized BI NPs via berberine (BBR) indocyanine green (ICG) formed BIP wrapping with polydopamine (PDA), were delivered pocket hitchhiking anaerobic probiotic Bifidobacterium bifidum (Bif). released berberin under near-infrared (NIR) irradiation, which inhibited sulfur metabolism Porphyromonas gingivalis mild photothermal action BBR-targeted serine acetyltransferase, a decrease resistance oxidative stress, thus exerting nonantibiotic bacteriostatic effect. This effect facilitated uptake bygingival fibroblasts. Moreover, BBR targeted nuclear factor-erythroid 2-related factor 2 (NRF2) reduce ferroptosis, fibroblast supernatant modulated macrophage polarization through NF-κB pathway. In periodontitis rat model, Bif@BIP+NIR treatment carried deep pockets, decreasing local ferroptosis alleviating symptoms. To summarize, engineered probiotics target low-oxygen pockets delivery, P. bacterial inhibition, mitigate
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Language: Английский
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0
Giant, Journal Year: 2024, Volume and Issue: 18, P. 100256 - 100256
Published: March 26, 2024
In recent years, significant advancements in nanotechnology have yielded remarkable improvements biomedical applications. Nanocarriers, harnessed from the principles of nanotechnology, garnered widespread utilization medicine delivery and diagnostics. However, progression nanocarriers has been hindered by two key challenges: low drug loading capacity potential for carrier-induced toxicity. To surmount these obstacles, rapid development expansion carrier-free systems (CFDDSs) composed pure drugs prodrugs emerged as a promising solution. Extensive endeavors undertaken to explore novel excipients, therapeutic agents, self-assembly processes, mechanisms, aimed at expanding horizons CFDDSs enhancing their efficacy. This comprehensive review provides an overview CFDDSs, elucidating mechanisms. Additionally, we examine diverse applications while shedding light on challenges ahead future clinical implementation CFDDSs. serves enhance our understanding intricate mechanisms governing nanoassembly formation fosters advancement expansive realm research.
Language: Английский
Citations
2
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158477 - 158477
Published: Dec. 9, 2024
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 27, 2024
Abstract Background Ulcerative colitis (UC) is a chronic intestinal inflammation, resulting in global healthcare challenge with no real specific medicine. Natural medicines are recognized as potential clinical alternative therapy, but their applications limited by poor solubility and low bioavailability. Results In this work, inspired the natural of ancient China, novel functional carbon dots derived from Magnetite Medicated Leaven (MML-CDs) were synthesized hydrothermal method, confirmed ultrasmall nano-size (3.2 ± 0.6 nm) Fe doped surface structure, thereby excellent gastrointestinal stability, remarkable capabilities eliminating ROS, highly biocompatibility. With external stimuli, oral administration MML-CDs demonstrated obvious alleviation to UC. Further experiments pointed that could improve hemostasis capability, suppress inflammation reactions oxidative stress, up-regulate expression tight junction proteins. Furthermore, also showed well regulation dysbiosis flora. Conclusion Overall, above evidence reveals green-synthesized can significantly alleviate bleeding, inhibit colon repair colonic barrier damage, further regulating flora microenvironment. Our findings provide an efficient therapy strategy for ulcerative colitis. Graphical
Language: Английский
Citations
1
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
1
Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Natural small-molecule drugs have been used for thousands of years the prevention and treatment human diseases. Most natural products available on market modified into various polymer materials improving solubility, stability, targeted delivery drugs. However, these nanomedicines formed based carriers would produce severe problems such as systemic toxicity kidney metabolic stress. In contrast, carrier-free by their self-assembly in water inherent advantages low toxicity, good biocompatibility, biodegradability. This review summarizes assembly process application products, which are mainly driven multiple non-covalent interactions, includes single-molecule assembly, bimolecular drug-modified organogels. Meanwhile, molecular mechanism involved different processes is also discussed. Self-assembly simulation structural modification or traditional Chinese medicine molecules using dynamics computer-assisted methods proposed, will lead to discovery more nanomedicine drug systems. Overall, this provides an important understanding strategy study multi-molecule nanomedicines.
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Abstract The emergence of nanotechnology has significantly promoted the development medical field, and nanomedicines broadened application potential existing drugs. However, at present, many new types suffer from poor stability, uncertain safety, complex preparation processes, high costs. nano‐ Chinese herbal medicines (CHMs) provided ideas for nanomedicines. Nano‐CHMs are simple to prepare, easily accessible, possess stable reliable safety. This review highlighted nanoparticles with pharmacological activities important material basis CHM formula decoctions. Given composition formulas, article further presented nanoaggregates exosome‐like vesicle nanostructures in single herbs, self‐assembly effect natural compounds. For first time, this systematically introduced characteristics formulas herbs then compounds, nano‐aggregates unclear components structures self‐assembled supramolecular materials. It also summarized problems be solved research CHMs applications, aiming provide guidance modernization ‐related nanoparticles.
Language: Английский
Citations
1