Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101386 - 101386
Published: Dec. 9, 2024
Language: Английский
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)
Published: Sept. 14, 2023
Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.
Language: Английский
Citations
43
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112810 - 112810
Published: Jan. 1, 2025
Language: Английский
Citations
3
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 396 - 414
Published: Jan. 20, 2025
Language: Английский
Citations
3
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 8, 2024
Abstract Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) inflammatory factors levels the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays vital role this fatal injury. At present, we developed novel class of polydopamine (PDA) coated cerium dioxide (CeO 2 ) (Ce@P) acts as potent ROS scavenger for scavenging intracellular suppressing responses against ALI. Herein, aimed to identify Ce@P combining NIR irradiation could further strengthen its capacity. Specifically, triggered exhibited most antioxidant anti-inflammatory behaviors lipopolysaccharide (LPS) induced macrophages through decreasing levels, down-regulating TNF-α, IL-1β IL-6, up-regulating level cytokine (SOD-2), inducing M2 directional polarization (CD206 up-regulation), increasing expression HSP70. Besides, performed intravenous (IV) injection LPS ALI rat model, found it significantly accumulated tissue 6 h after injection. It was also observed + presented superior inflammation, alleviating diffuse alveolar damage, well promoting repair. All all, has strategy using synergistic enhanced treatment ALI, which can serve promising therapeutic clinical derived diseases well.
Language: Английский
Citations
10
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 4764 - 4771
Published: Feb. 21, 2024
Nanozymes are nanomaterials with natural enzyme characteristics, which expected to be potential substitutes of traditional enzymes. In this study, the 1Al/MIL-100(Fe) nanozymes excellent peroxidase-like activity were synthesized by ultrathin modification (one-cycle Al2O3) strategy atomic layer deposition, whose is almost doubled compared MIL-100(Fe) nanozymes. Investigation catalytic mechanism indicates that increased amount hydroxyl radical responsible for much-enhanced Furthermore, effect designed inhibited glutathione through consuming oxidized 3,3′,5,5′-tetramethylbenzidine in reaction system. The also achieve sensitive and selective detection glutathione, have an linear response concentration range 0.01–1000 μM a limit 2.2 nM. can potentially extended synthesize other high-efficiency nanozyme materials.
Language: Английский
Citations
8
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101534 - 101534
Published: Jan. 29, 2025
The treatment and management of kidney diseases pose a significant global burden. Due to the presence blood circulation barriers glomerular filtration barriers, drug therapy for faces challenges such as poor renal targeting, short half-life, severe systemic side effects, severely hindering therapeutic progress. Therefore, research development kidney-targeted agents is great clinical significance. In recent years, application nanotechnology in field nephrology has shown potential revolutionizing diagnosis diseases. Carefully designed nanomaterials can exhibit optimal biological characteristics, influencing various aspects circulation, retention, excretion. Rationally designing modifying based on anatomical structure pathophysiological environment achieve highly specific or nanodrug delivery systems both feasible promising. Based targeted diseases, this review discusses advantages limitations current nanomedicine summarizes active/passive targeting strategies, order further promote through preliminary summary previous studies future prospects.
Language: Английский
Citations
1
Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112363 - 112363
Published: Dec. 1, 2024
Language: Английский
Citations
7
Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 26, P. 100796 - 100796
Published: May 6, 2024
Language: Английский
Citations
6
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 11, 2024
Cancer is becoming a global threat, as the cancerous cells manipulate themselves frequently, resulting in mutants and more abnormalities. Early-stage real-time detection of cancer biomarkers can provide insight into designing cost-effective diagnostic therapeutic modalities. Nanoparticle quantum dot (QD)-based approaches have been recognized clinically relevant methods to detect disease at molecular level. Over decades, an emergent noninvasive approach, photothermal therapy has evolved eradicate cancer. Moreover, various structures, viz., nanoparticles, clusters, dots, etc., tested bioimaging agents identify tumor selectively. Among them, QDs versatile probes. They attracted enormous attention for imaging applications due their unique colloidal stability, optical physicochemical properties, biocompatibility, easy surface conjugation, scalable production, etc. However, few critical concerns QDs, precise engineering sensing, selective interaction with biological system, associated toxicity, restrict potential intervention curing are yet be explored. According U.S. Food Drug Administration (FDA), there no specific regulation approval nanomedicines. Therefore, these nanomedicines undergo traditional drug, biological, device process. market survey increasing, prospects translational nanomedicine very promising. From this perspective, we discuss importance imaging, usage pertinent cancer, especially its early stages. also rapidly growing view QDs. The long-term safety studies cellular could enhance visibility bring photothermally active clinical stage concurrently FDA approval.
Language: Английский
Citations
5
Applied Catalysis A General, Journal Year: 2024, Volume and Issue: unknown, P. 120054 - 120054
Published: Dec. 1, 2024
Language: Английский
Citations
5