ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 7(1), P. 258 - 267

Published: Dec. 27, 2024

Diabetic wounds are extremely difficult to heal due the long duration and high recurrence rate. The bacterial infection caused by elevated blood glucose negatively affects speed of wound healing. In this article, radially oriented nanofibers containing natural antimicrobial agent purslane were prepared electrostatic spinning. Subsequently, asiaticoside was loaded onto surface fibers spraying. experimental results indicated that radial nanofiber membranes exhibited uniform diameter distribution, suitable water vapor permeability, good hydrophilicity as well excellent antibacterial performance biocompatibility. Due ordered arrangement, healing ability, regular granulation tissue growth, collagen deposition. More importantly, fiber structure significantly promoted cell proliferation adhesion. Based on these results, with a have potential application prospects in field chronic diabetic

Language: Английский