Micromachines,
Journal Year:
2024,
Volume and Issue:
15(7), P. 882 - 882
Published: July 4, 2024
In
this
paper,
we
investigate
the
electro-osmotic
flow
(EOF)
and
mass
transfer
of
a
Newtonian
fluid
propelled
by
pressure
gradient
alternating
current
(AC)
electric
field
in
parallel
microchannel
with
sinusoidal
roughness
modulated
charged
surfaces.
The
two-wall
is
described
in-phase
or
out-of-phase
sine
functions
small
amplitude
δ.
By
employing
method
perturbation
expansion,
semi-analytical
solutions
Poisson–Boltzmann
(P–B)
equation
based
on
Debye–Hückel
approximation
modified
Navier–Stokes
(N–S)
are
obtained.
numerical
solution
concentration
obtained
finite
difference
method.
effects
roughness,
surface,
AC
potential
field,
velocity
discussed.
Under
influence
surface
vortices
generated.
oscillates
due
to
effect
field.
results
indicate
that
solute
diffusion
becomes
enhanced
when
oscillation
Reynolds
number
below
specific
critical
value,
it
slows
down
exceeds
value.
Journal of drug targeting,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 41
Published: April 25, 2025
Nanoemulgels
are
an
advanced
innovation
in
dermatological
formulations
designed
to
treat
various
skin
diseases.
By
combining
the
advantages
of
hydrogels
and
nanoemulsions,
these
hybrid
systems
optimize
drug
delivery
improve
therapeutic
results.
Because
their
nanoscale
droplets,
nanoemulsions
solubility
by
increasing
surface
area
stability
bioavailability
medications.
When
embedded
a
hydrogel
matrix,
transformation
into
nanoemulgels,
provide
regulated
prolonged
release,
ensuring
sustained
action.
The
ability
nanoemulgels
penetrate
deeply
layers
get
past
obstacles
like
stratum
corneum
penetration
efficacy
makes
them
highly
effective
dermatology.
Since
gel
component
helps
reduce
interfacial
tension
rise
spreading
coefficient
along
with
viscosity.
benefits
using
NEGs
for
external
use
include
thixotropic,
greaseless,
readily
dispersed
properties,
longer
shelf
life,
emollient,
effortlessly
removed,
non-staining
clear,
cosmetically
attractive
environment
friendly
characteristics.
providing
overview
research
on
nanoemulgels'
permeability
mechanisms,
pharmacokinetics,
uses,
difficulties
involved
topical
disorders,
this
review
emphasizes
potential
materials
as
Vaccines,
Journal Year:
2025,
Volume and Issue:
13(5), P. 469 - 469
Published: April 27, 2025
Background:
The
high
incidence
and
mortality
rates
of
cancer
have
kept
it
at
the
top
research
agenda
for
global
healthcare
industry,
as
well
put
serious
economic
pressure
on
families
society.
It
has
gradually
been
recognised
that
reducing
through
various
interventions
combining
prevention
treatment
are
key
to
alleviating
burden
cancer.
Methods:
Retrieve
summarize
literature
related
delivery
methods
tumor
vaccines,
investigate
whether
these
applied
clinically
or
used
in
clinical
trials.
Results:
there
a
variety
vaccine
development,
but
only
very
small
number
studies
able
make
strides
towards
implementing
clinic,
which
is
closely
linked
drawbacks
with
means
delivery.
Conclusions:
This
review
analyses
reasons
why
difficult
apply
clinic
from
point
view
method
rather
than
design
vaccine.
also
describes
some
not
yet
vaccines
and,
considering
this
conjunction
those
currently
purpose,
predicts
their
prospects
future
application.
AAPS PharmSciTech,
Journal Year:
2025,
Volume and Issue:
26(5)
Published: May 6, 2025
Abstract
Novel
topical
nanosponges
were
implemented
to
improve
the
skin
availability
of
simvastatin
(SV)
for
treating
full-thickness
wounds
while
controlling
scarring
process.
SV
exhibits
great
potential
in
various
diseases
owing
its
antibacterial,
antioxidant,
anti-inflammatory,
and
immunomodulatory
properties.
However,
poor
oral
bioavailability
systemic
side
effects
have
hindered
clinical
application
dermatology.
For
first
time,
utilized
target
injured
skin,
creating
an
reservoir
within
wound
bed
enhance
therapeutic
efficacy
minimizing
adverse
effects.
Herein,
SV-loaded
ethyl-cellulose
(SV-NS)
prepared
using
emulsion
solvent
evaporation
technique,
optimizing
organic
solvents,
concentration,
stabilizer
concentration.
The
selected
SV-NS
(20
mg
SV)
exhibited
nanoporous
particles
(786.2
±
50
nm),
a
specific
surface
area
10.3
m
2
/g,
total
pore
volume
0.016
cm
3
offering
sustained
release
enhanced
retention
capacity.
In
vivo
studies
on
rat
confirmed
that
(5
SV,
applied
every
5
days)
significantly
accelerated
closure
(
P
<
0.0001),
achieving
76.23
3.20%
by
day
8,
47%
improvement
over
free
SV.
Consequently,
facilitated
exceeding
90%
11,
whereas
required
16
days
attain
comparable
level,
representing
31.2%
faster
healing
rate.
Histological
analysis
further
revealed
promoted
optimal
epidermal
layer
formation
well-organized
collagen
deposition,
with
expression
0.0001)
reaching
59.85
3.17%
16.
Conclusively,
enhances
SV’s
dermal
availability,
improving
effects,
demonstrating
promising
approach
restoration.
Graphical
Micromachines,
Journal Year:
2024,
Volume and Issue:
15(7), P. 882 - 882
Published: July 4, 2024
In
this
paper,
we
investigate
the
electro-osmotic
flow
(EOF)
and
mass
transfer
of
a
Newtonian
fluid
propelled
by
pressure
gradient
alternating
current
(AC)
electric
field
in
parallel
microchannel
with
sinusoidal
roughness
modulated
charged
surfaces.
The
two-wall
is
described
in-phase
or
out-of-phase
sine
functions
small
amplitude
δ.
By
employing
method
perturbation
expansion,
semi-analytical
solutions
Poisson–Boltzmann
(P–B)
equation
based
on
Debye–Hückel
approximation
modified
Navier–Stokes
(N–S)
are
obtained.
numerical
solution
concentration
obtained
finite
difference
method.
effects
roughness,
surface,
AC
potential
field,
velocity
discussed.
Under
influence
surface
vortices
generated.
oscillates
due
to
effect
field.
results
indicate
that
solute
diffusion
becomes
enhanced
when
oscillation
Reynolds
number
below
specific
critical
value,
it
slows
down
exceeds
value.
