Science China Materials, Journal Year: 2024, Volume and Issue: 67(12), P. 3811 - 3832
Published: Oct. 28, 2024
Language: Английский
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: May 21, 2024
The repair and regeneration of cartilage has always been a hot topic in medical research. Cartilage organoids (CORGs) are special tissue created using engineering techniques outside the body. These engineered tissues provide models that simulate complex biological functions cartilage, opening new possibilities for regenerative medicine treatment strategies. However, it is crucial to establish suitable matrix scaffolds cultivation CORGs. In recent years, utilizing hydrogel culture stem cells induce their differentiation into chondrocytes emerged as promising method vitro construction this review, methods establishing CORGs summarized an overview advantages limitations matrigel such provided. Furthermore, importance ECM alternative substitutes Matrigel, alginate, peptides, silk fibroin, DNA derivatives discussed, pros cons these hydrogels outlined. Finally, challenges future directions research discussed. It hoped article provides valuable references design development
Language: Английский
Citations
29
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Abstract Dentin hypersensitivity (DH), marked by exposed dentinal tubules, presents as a sharp toothache triggered stimuli and subsides when the are removed. To address limitations of current commercial desensitizers in terms acid resistance, friction stability, black phosphorus nanosheet‐composited methacrylate gelatin hydrogel (GelMA/BP) is developed for DH treatment, leveraging synergistic effects photothermal therapy biomineralization. Incorporating BP nanosheet provided GelMA/BP with stable response continuous release phosphate anions, which blocked tubules converting light energy into heat initiating In vitro desensitizing showed that tubule diameter GelMA/BP50 group (0−1.13 µm) significantly reduced compared to DH‐model (0−3.14 µm). The achieved an 86% occlusion rate, resistance 80%, 76%, long‐term stability 74%. vivo studies further validated efficacy GelMA/BP50, showing reduction (0−0.37 rate 79%, alleviated increased intake weight. These results demonstrate this acts effective sealant, offering promising clinical benefits topical treatment DH.
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 19, 2025
Abstract Dentin hypersensitivity (DH), caused by the exposure of dentin tubules, is a common complaint dental patients. Although occlusion exposed tubules primary treatment approach, complex oral environment, and multiple simultaneous requirements often hinder its implementation. In this study, strawberry‐shaped hemispheric Janus particles (JPs) are synthesized, their use in DH evaluated vitro an animal model. The side JPs modified with polymers quaternary ammonium salts (QASs) to form superhydrophobic coating antibiofilm properties, while flat catechol groups able strong bonds dentin. Even after 1 h ultrasonication or 1000 rounds thermal cycling, completely occluded JPs. Moreover, biofilm formation not observed, area living bacteria less than 1% compared blank control sodium fluoride (NaF)‐treated groups. rat model, fixed specimens at day 3, much earlier obtained commonly used NaF. These results demonstrate that can provide novel approach DH.
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 403 - 416
Published: Feb. 12, 2025
Language: Английский
Citations
0
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Rapid gelation hydrogels have garnered significant attention due to their simple synthesis, high efficiency, low cost, and environmental sustainability, which enable meet critical demands for scalability green chemistry unlocking opportunities across diverse application fields. This review synthesizes current advancements in the mechanisms driving rapid gelation, encompassing self-assembly processes, MXene-triggered redox-driven reactions, coordination chemistry, Schiff base other innovative strategies. The discussion extends far-reaching applications, from advanced therapeutic platforms high-performance energy devices precision sensors adaptive soft actuators. By critically evaluating recent progress addressing existing challenges, this not only deepens understanding of mechanisms, but also provides scientific insights practical guidance foster interdisciplinary integration drive material innovation synthesis technologies.
Language: Английский
Citations
0
Journal of Dentistry, Journal Year: 2025, Volume and Issue: unknown, P. 105719 - 105719
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Dentistry, Journal Year: 2025, Volume and Issue: unknown, P. 105763 - 105763
Published: April 1, 2025
Language: Английский
Citations
0
Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 438 - 438
Published: April 22, 2025
(1) Background: Tannic acid (TA), a water-soluble polyphenol extensively found in numerous plant species, possesses antimicrobial, anti-inflammatory, antioxidant, and adhesive properties. This scoping review aims to synthesize existing knowledge on TA applications unveil its potential uses dentistry. (2) Methods: A comprehensive search across six electronic databases (PubMed, Cochrane, Embase, Scopus, Web of Science, Opengrey) was conducted October 2024. Two reviewers performed the screening risk bias analysis independently following PRISMA-ScR guidelines. The findings are presented narrative summary. (3) Results: Five hundred twelve records were identified from databases. After removing duplicates applying eligibility criteria, ninety-six studies ultimately included this review. Results indicate that has been employed managing dentin hypersensitivity, dental caries, periodontal mucosal diseases, as well dentition defects with prostheses. Furthermore, displays enhancing performance bonding adhesives, root canal irrigants, filling materials. However, it is noteworthy exhibit varied experimental settings, inconsistent outcome measures, lack extensive clinical research, insufficient observation periods. (4) Conclusions: promising biomaterial various fields, such endodontics, periodontology, prosthodontics, public health. Its properties warrant future exploration unleash these potentials provide robust scientific evidence guides practice advances oral healthcare.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 27, 2025
Abstract Dental caries is a global oral dilemma leading to demineralization of tooth hard tissues and exposure dentinal tubules (DTs). Multifunctional restorative strategies, including remineralization, antibacterial properties, DT occlusion, are urgently needed for dental management but remain significant challenge. Herein, the polyaspartic acid‐calcium‐lanthanum suspension (5 g L −1 ‐3.06 м‐0.34 м) followed by phosphate solution (2.04 adopted conduct polyelectrolyte‐cation complexes pre‐precursor process. This strategy, first time, successfully induces La‐doped intrafibrillar mineralization collagen fibrils with lanthanum‐doped hydroxyapatite (La‐HAp). After sequential application two media, demineralized dentin fully remineralized DTs deeply occluded depth 100 µm La‐HAp after 7 d incubation in artificial saliva or cavity rabbit. The demonstrates properties against cariogenic bacteria ( Streptococcus mutans ) both vitro vivo, its mechanical almost restored those intact dentin. media cause no apparent irritation mucosa pulp. Hence, this multifunctional strategy confers surface blocks invasion through DTs, providing insight into clinical accompanied hypersensitivity.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132431 - 132431
Published: May 15, 2024
Language: Английский
Citations
3