Damaged
skin
compromises
its
ability
to
effectively
prevent
the
invasion
of
harmful
bacteria
into
tissue,
leading
bacterial
infection
wound
and
hindering
healing
process.
To
address
this
challenge,
we
have
developed
a
multifunctional
asymmetric
dressing
(CuPt-Cur-ABC)
that
addresses
lack
bactericidal
activity
release
active
ingredients
in
conventional
cellulose
(BC),
which
can
be
employed
create
barrier
defense
between
surrounding
environment.
Compared
with
BC,
(ABC)
used
starch
as
pore-causing
agent,
forming
holes
different
sizes
at
top
bottom,
enhanced
ABC
load
moderate-release
drugs.
First,
as-synthesized
CuPt
nanozymes
an
octopod
nanoframe
structure
had
multiple
enzymatic
activities
including
peroxidase-like,
catalase-like,
glutathione
peroxidase-like
activities.
Then,
curcumin
(Cur)
were
loaded
under
ultrasound.
Under
808
nm
laser
irradiation,
nanocomposites
possessed
good
photothermal
properties.
So
therapy
combined
chemodynamic
inherent
antibacterial
performance
Cur
achieved
99.3%
99.6%
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Microbial Cell Factories,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 12, 2025
Hydrogen
sulfide
(H2S)
gas,
characterized
by
its
low
odor
threshold
and
toxicity,
poses
significant
challenges
in
non-point
source
management.
Traditional
biotechnologies
are
effective
removing
malodorous
gases
from
point
sources
but
they
limited
for
control.
In
this
study,
the
sqr
pdo
genes
Cupriavidus
pinatubonensis
JMP134
were
introduced
into
bacterial
cellulose-producing
strain
Kosakonia
oryzendophytica
FY-07.
This
genetic
modification
enhanced
strain's
sulfur
oxidation
capacity,
which
increased
over
time,
with
an
average
transformation
capacity
of
approximately
275
mg·L−
1·day−
1.
By
incorporating
1%
activated
carbon,
efficient,
naturally
degradable
bio-composite
membrane
was
developed,
achieving
a
maximum
H2S
adsorption
7.3
g·m−
3·day−
FY-07
remained
stable
soil
improved
microbial
community
treatment.
The
resulting
is
environment-friendly
making
it
suitable
emergency
control
landfills.
study
offers
recommendations
using
materials
managing
hydrogen
emissions.
Bacterial
resistance
to
antibiotics
has
rendered
bacterial
infections
an
escalating
threat
public
health,
prompting
numerous
researchers
strive
towards
the
development
of
novel
antimicrobial
agents.
Designable
ionic
liquids
(ILs)
have
gained
increasing
prominence
in
field
antibacterials.
However,
certain
ILs
exhibit
suboptimal
activity
and
limited
biocompatibility.
In
this
study,
we
synthesized
liquid-derived
carbon
dots
(IL-CDs)
through
vinyl
epoxy
group
reactions,
resulting
enhanced
efficacy
favorable
The
IL-CDs
retain
antibacterial
structure
characteristic
ILs,
including
a
positively
charged
imidazole
long
alkyl
chain.
Moreover,
demonstrate
selective
action
against
Staphylococcus
aureus
(S.
aureus)
while
effectively
inhibiting
S.
biofilm
growth.
Notably,
superior
potency
compared
commercially
available
quaternary
ammonium
salt-based
We
conducted
comprehensive
investigations
into
mechanism
which
primarily
involves
electrostatic
interactions,
hydrophobic
as
well
generation
reactive
oxygen
species
(ROS)
within
bacteria
cells.
vivo
experiments
demonstrated
that
significantly
alleviate
inflammation
expedite
wound
healing
aureus-infected
mice
models;
thus
highlighting
their
potential
therapeutic
candidates
for
diseases
resembling
infection-like
conditions.
Importantly,
our
work
presents
approach
utilizing
IL-based
materials
developing
effective
antibacterials
thereby
offering
new
insights
application
prospects
IL-derived
materials.
